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A preparation method of artificial hard bone scaffold with controllable growth factor concentration gradient

A growth factor and concentration gradient technology, which is applied in the field of preparation of medical artificial bone graft materials, can solve the problems of high sintering process temperature that is not suitable for the activity of growth factor protein, the inability to realize the precise distribution of scaffold growth factors, and no consideration of regulation.

Active Publication Date: 2021-05-07
西安博恩生物科技有限公司
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Problems solved by technology

The bone scaffold preparation method proposed in the above-mentioned published patents only focuses on the three-dimensional structure of the scaffold, without considering the regulation of growth factors, and the high temperature of the sintering process is not suitable for maintaining the activity of growth factor proteins, and cannot achieve accurate growth factors inside the scaffold. distributed

Method used

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Embodiment Construction

[0035] Embodiments of the present invention are described in detail below, and the embodiments are exemplary and intended to explain the present invention, but should not be construed as limiting the present invention.

[0036]Bone morphogenetic protein (BMP-2) is a secreted, hydrophobic, acidic glycoprotein that can promote the differentiation of undifferentiated mesenchymal cells and osteoblast precursor cells into osteoblasts, and has high osteoinductive The ability to further guide the expression of osteoblasts has been recognized as the strongest osteoinductive factor. In this implementation example, bone morphogenetic protein growth factors were used to prepare artificial hard bone scaffolds.

[0037] The preparation of the artificial hard bone scaffold with controllable growth factor concentration gradient specifically includes the following steps:

[0038] Step 1: Use Micro-CT to scan the bone to be printed, obtain the 3D model of the bone to be printed after computer...

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Abstract

The present invention proposes a method for preparing an artificial hard bone scaffold with a controllable concentration gradient of growth factors. Firstly, layered printing is used in the printing process, and growth factors are printed on each layer of bioceramic material according to a certain concentration gradient distribution requirement to realize bioceramics Materials and growth factors are layered and stacked to form a growth factor-bone scaffold composite structure that satisfies the controllable concentration gradient of growth factors. Secondly, during the printing process, there is no high-temperature and high-pressure environment, which ensures the activity of growth factors. At the same time, multiple nozzles are used for collaborative printing, which can further realize the accurate and controllable concentration gradient of growth factors inside the bone scaffold.

Description

technical field [0001] The invention relates to the field of preparation of medical artificial bone graft materials, in particular to a preparation method of an artificial hard bone support with controllable growth factor concentration gradient. Background technique [0002] The human skeleton itself has a certain self-repair ability, but for severe bone defects caused by external factors, the human body cannot repair itself, and surgical transplantation is required. At present, there are mainly autologous bone, allogeneic bone and artificial synthetic materials that can be used as graft materials. Although the effect of autologous bone transplantation is good, the quantity is limited and it is easy to cause complications; while allogeneic bone has the possibility of virus infection and rejection; in contrast, artificial synthetic materials have excellent biocompatibility and degradability, and are used in more suitable for bone repair. An ideal artificial bone scaffold sh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/12A61L27/22A61L27/54A61L27/58
CPCA61L27/12A61L27/227A61L27/54A61L27/58A61L2300/252A61L2300/412A61L2300/414A61L2430/02C08L89/00
Inventor 汪焰恩宋瑶国玉鸿蔡显轩柴卫红杨明明王国伟饶逸文姜安国
Owner 西安博恩生物科技有限公司
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