A kind of carboxymethyl chitosan quaternary ammonium salt thermosensitive gel and preparation method thereof

Abstract

The invention discloses a thermosensitive gel of carboxymethyl chitosan quaternary ammonium salt, which comprises 1% to 3% of carboxymethyl chitosan quaternary ammonium salt, 24% to 35% of poloxamer series polymers, 0.1% to 1% moisturizer and 60% to 75% pure water. The invention also provides a preparation method of carboxymethyl chitosan quaternary ammonium salt thermosensitive gel, which comprises 1% to 3% carboxymethyl chitosan quaternary ammonium salt, 24% to 35% poloxamer series polymers, 0.1 %-1% moisturizing agent and 60%-75% pure water are mixed overnight at 0-5 DEG C, and after all components are completely dissolved, they are evenly stirred to obtain carboxymethyl chitosan quaternary ammonium salt thermosensitive gel. The gelation temperature of the carboxymethyl chitosan quaternary ammonium salt temperature-sensitive gel of the present invention is the same as that of the human body, the gelation time is extremely short, and the antibacterial performance is remarkable; the preparation of the carboxymethyl chitosan quaternary ammonium salt temperature-sensitive gel of the present invention The method is convenient to operate, simple in process, short in preparation time, cheap in required equipment and raw materials, low in production cost, suitable for large-scale production, and has good prospects for popularization and application.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations of medical engineering, and in particular relates to a carboxymethyl chitosan quaternary ammonium salt temperature-sensitive gel and a preparation method thereof. Background technique [0002] Thermosensitive gel refers to a preparation that transforms from a liquid state into a non-chemically cross-linked semi-solid gel by utilizing the phase transition of the polymer material in response to the external temperature after administration in a solution state. Thermosensitive gels can realize injection implantation and drug sustained release, which play an important role in the field of pharmacy and become a research hotspot in recent years. [0003] Authorized notification number CN 103834045 B's Chinese invention patent "A Two-way Reversible Thermosensitive Gel and Its Preparation Method" discloses a method of physical cross-linking preparation of chitosan, chitosan quaternary ammonium s...

AI Technical Summary

Problems solved by technology

However, there are also some problems in the application of carboxymethyl chitosan quaternary ammonium salt in thermosensitive gels.

Although CN 10488824 A discloses amphiphilic carboxymethyl chitosan derivatives / poloxamer temperature-sensitive in-situ hydrogels, amphiphilic carboxymethyl chitosan derivatives are only It is used to improve the performance of poloxamer thermosensitive in-situ hydrogel, such as increasing the gelation temperature, hydrogel stability and the performance of sustained-release drugs, and the preparation method of the gel system is very complicated. Time is too long, not conducive to mass production

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