Growth promotion preparation capable of increasing content of ginkgolide B in gingko leaves

Abstract

The invention relates to the technical field of biology, and particularly provides a growth promotion preparation capable of increasing content of ginkgolide B in gingko leaves. The growth promotion preparation is composed of, by weight, 1.5-3.5 parts of Stereum hirsutum, 5.6-7.8 parts of Fusarfum tricinctum, and 15.0-20.0 parts of distilled water. The invention also relates to a preparation method and an application of the growth promotion preparation. According to the growth promotion preparation, instead of single separation and purification methods for acquiring a large amount of the ginkgolide B, by adding ginkgolide to a culture medium, bacteria are prepared through liquid culture technology with the Stereum hirsutum and Fusarfum tricinctum as bacterial strains, wherein the bacteria,as a catalyst, can convert ginkgolide A, ginkgolide C and ginkgolide M into the ginkgolide B. The growth promotion preparation greatly increases economic value and medicinal value of the product.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a growth-promoting preparation for increasing the content of lactone B in ginkgo leaves. [0002] The invention also relates to a preparation method and application of a growth-promoting preparation for increasing the content of lactone B in ginkgo leaves. Background technique [0003] Studies have proved that ginkgolide is one of the main active ingredients in Ginkgo biloba, and is a specific and effective platelet activating factor (Platelet activating factor PAF) receptor antagonist. Platelet activating factor is an endogenous phospholipid secreted by platelets and various inflammatory tissues. It is the most effective platelet aggregation inducer found so far, and is closely related to the occurrence and development of many diseases. Ginkgolides, as specific antagonists of PAF receptors, have a wide range of pharmacological effects. Studies have found that ginkgolide B has prot...

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Problems solved by technology

And there are only nine articles about the preparation of ginkgolide B (a new method for extracting ginkgolide B from ginkgo biloba or ginkgo leaf extract, application number 200510063407.X; a kind of separation of ginkgolide from ginkgolide mixture The method of B, application number: CN201010608847.X, etc.), the ginkgolides contain ginkgolides A, B, C, M and other homologues in the ginkgolides, these patents adopt separation technology to separate ginkgolides from the ginkgolide mixture B, it is difficult to produce ginkgolides in large quantities in industry B

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