Compounds that Prevent Kidney Damage

A compound and technology for acute kidney injury, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of lack of effective treatment drugs for kidney injury, achieve the effect of reducing creatinine value and improving pathological manifestations

Active Publication Date: 2020-04-17
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide compounds for preventing and treating kidney damage, so as to solve the problem of lack of effective drugs for treating kidney damage in the prior art

Method used

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  • Compounds that Prevent Kidney Damage
  • Compounds that Prevent Kidney Damage
  • Compounds that Prevent Kidney Damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Therapeutic effect of the compound of the present invention on renal injury

[0048] 1. Mouse model of acute kidney injury caused by ischemia-reperfusion

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Abstract

The invention relates to a compound for preventing and treating renal injury, and belongs to the field of medicine, and solves the technical problem of lack of an effective therapeutic drug for the renal injury in the prior art. The technical proposal provides use of a compound of the formula I, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof in preparingdrugs for prevention and treatment of the renal injury. Experimental results show that the compound has an exact therapeutic effect on the renal injury, can significantly improve the pathological manifestations of damaged renal tissues, reduces renal injury score and creatinine level, and provides a new drug selection for clinical prevention and treatment of the renal injury.

Description

Technical field [0001] The invention relates to a compound for preventing and treating kidney injury, and belongs to the field of medicine. Background technique [0002] Kidney injury is a common nephrotic medical syndrome. The pathological manifestations are the death of renal tubular epithelial cells, disappearance of brush border, tubule obstruction, and endothelial cell damage. It can lead to multiple organ failure and is a critically ill disease with a high risk of death. It is currently believed that the pathophysiological mechanisms of the onset and progression of kidney injury include oxidative stress, endoplasmic reticulum stress, and autoimmune responses. Immune inflammation, ischemia, oxidative stress, poisoning, and autoimmunity are interrelated, promote or Restriction, forming a very complex network relationship, participating in the formation and progress of kidney injury in many aspects. [0003] The treatment of kidney injury is mainly based on supportive treatment...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/415A61P13/12A61P9/10A61P43/00
CPCA61K31/415A61P9/10A61P13/12A61P43/00
Inventor 马良石敏杜晓艳郭帆付平
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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