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Preparation of oxidized cellulose and application thereof to washing and drug loading

A technology for oxidizing cellulose and cellulose, which is applied in the fields of medicine and chemical industry, can solve the problems that cellulose needs to be improved, and achieve the effect of good hydrophilic and lipophilic or low toxicity and low particle size

Active Publication Date: 2018-11-02
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current methods for modifying cellulose still need to be improved

Method used

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  • Preparation of oxidized cellulose and application thereof to washing and drug loading
  • Preparation of oxidized cellulose and application thereof to washing and drug loading
  • Preparation of oxidized cellulose and application thereof to washing and drug loading

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] In this example, oxidized cellulose was prepared as follows:

[0089] 1. Corn cob gas explosion residue:

[0090] Weigh 100g of corncobs with a balance, put them in a 2L beaker, add 1000ml of deionized water, completely submerge the corncobs, soak for 8 hours, drain the water, and explode with sulfuric acid steam. The explosion pressure is 0.9MPa, and the pressure is maintained for 5 minutes. The gas explosion residue was extracted with hot water at 80°C for 2 times, each time for 1 hour, and the residue was washed with water until it was neutral. Freeze-dried for later use.

[0091] 2. Extraction of cellulose

[0092] Weigh 10mg of the gas explosion residue, add 7.5ml of 2% sodium hydroxide, and heat at 160°C for 2h. After the reaction is completed and cooled, solid-liquid separation is carried out, and the solid is washed with deionized water until neutral, which is the extracted cellulose.

[0093] 3. TEMPO oxidation

[0094] (1) Weigh 1g of cellulose and dissol...

Embodiment 2

[0103] In this example, the effect of the amount of NaOH added in step (4) was investigated.

[0104] Specific operation:

[0105] (1) Prepare oxidized cellulose according to the method of Example 1, wherein the amount of NaOH added in step (4) is 3.75 mL, 6.25 mL and 12.5 mL respectively, to obtain oxidized cellulose 1, 2 and 3.

[0106] (2) Dissolve 2 mg of oxidized cellulose in 2 mL of water and observe its solubility. The results are as follows: Figure 5 shown.

[0107] It can be seen that the solubility of 3.75mL is poor, and as the amount of sodium hydroxide increases, the solubility of oxidized cellulose increases gradually.

[0108] (3) Carry out contact angle experiment with oxidized cellulose 2 and 3, specifically as follows:

[0109] The contact angle was measured by the tablet method. Weigh the cellulose, oxidized cellulose 2 (DO50) and oxidized cellulose 3 (DO100) obtained in the step (2) of Example 1 in equal amounts (40 mg), and after fully drying, press it...

Embodiment 3

[0113] In this example, the effect of the amount of TEMPO added was investigated.

[0114] Specific operation:

[0115] (1) Nanocellulose was prepared according to the method in Example 1, wherein the amount of TEMPO added was 0.05-0.10 g to obtain oxidized cellulose.

[0116] (2) Calculate the yield of oxidized cellulose based on the following formula:

[0117] Oxidized cellulose yield (%)=100%×the mass of oxidized cellulose obtained in step (7) / 1g.

[0118] The result is as Figure 7 shown. It can be seen that when the amount of TEMPO added is 0.008g, the effect is the best.

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Abstract

The invention provides a method for preparing oxidized cellulose, oxidized cellulose, use of the oxidized cellulose in preparation of a detergent and the detergent. The method comprises the followingsteps: extracting a corn cob to obtain cellulose; preparing a cellulose solution from the cellulose; performing TEMPO oxidation treatment on the cellulose solution to obtain the oxidized cellulose. The oxidized cellulose obtained by the method for preparing oxidized cellulose has a spherical structure, is 20 to 30 nanometers in particle size, and has higher amphiphilicity, a high emulsification property, low toxicity and higher application value.

Description

technical field [0001] The invention relates to the fields of medicine and chemical industry. Specifically, the present invention relates to the preparation of oxidized cellulose and its application in washing and drug loading. More specifically, the present invention relates to a method for preparing oxidized cellulose, oxidized cellulose, the use of oxidized cellulose in the preparation of detergents, probes or drug carriers, and detergents. Background technique [0002] Cellulose is a natural polymer with abundant content in nature, and it is a renewable resource and environment-friendly material. At present, it can be modified by artificial means to change its structure or physical and chemical properties, thereby improving its application value. [0003] However, the current methods for modifying cellulose still need to be improved. Contents of the invention [0004] The present invention aims to solve at least one of the technical problems existing in the prior ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B15/02C11D1/66A61K47/38
CPCA61K47/38C11D1/662C08B15/02
Inventor 李媛刘斌
Owner CHINA AGRI UNIV
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