Method for using near infrared spectroscopy to measure contents of multiple components in radix et rhizoma salviae miltiorrhizae medicinal material

A technology of near-infrared spectroscopy and near-infrared spectroscopy, which is applied in the field of detection of traditional Chinese medicine ingredients, can solve the problems of time-consuming and laborious, unreasonable harvesting time, and affecting the quality of Salvia miltiorrhiza medicinal materials.

Inactive Publication Date: 2018-11-02
TIANJIN TASLY PHARMA CO LTD
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Because the quality of medicinal materials is closely related to factors such as cultivation techniques, harvesting, processing, and storage, the current production of Danshen medicinals has irregular cultivation techniques and unreasonable harvesting time, resulting in great differences in the content of active ingredients in medicinal Danshen. , directly affect the quality of Danshen medicinal materials
The traditional analysis methods of traditional Chinese medicine include microscopic identification, thin layer chromatography, high performance liquid chromatography, gas chromatography, etc. These methods often have complicated pretreatment, cumbersome inspection process, high cost, time-consuming and laborious, and cannot meet the needs of large-scale on-site Shortcomings such as rapid analysis requirements, and all offline monitoring, cannot meet the needs of standardized planting, rational harvesting and efficient use of Danshen medicinal materials

Method used

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  • Method for using near infrared spectroscopy to measure contents of multiple components in radix et rhizoma salviae miltiorrhizae medicinal material
  • Method for using near infrared spectroscopy to measure contents of multiple components in radix et rhizoma salviae miltiorrhizae medicinal material
  • Method for using near infrared spectroscopy to measure contents of multiple components in radix et rhizoma salviae miltiorrhizae medicinal material

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Example 1: Method for establishing a model for quantitative analysis of Danshen medicinal materials near infrared spectroscopy

[0129] 1. NIR (near infrared) spectrum collection

[0130] After the Danshen medicinal material is crushed, pass through a 50-mesh medicinal material standard sieve, and mix well;

[0131] Sampling method: integrating sphere solid sampling;

[0132] Acquisition conditions: resolution 8cm -1 , the number of scans is 64 times, and the scan range is 12000~3800cm -1 , the data format is Lg(1 / R), 6 spectra are collected for each sample, and the average spectrum is calculated to establish a model.

[0133] The sample cup is shaken before each scan, and the thickness of the sample, the compactness of the filling, and the uniformity of the particles are all strived to be consistent in the experiment to reduce the impact on the experimental results.

[0134] 2. Content determination

[0135] 2.1 Determination of Tanshinone Ⅱ A, Tanshinone Ⅰ and Cryp...

Embodiment 2

[0156] Embodiment 2: the method for the determination of multi-component content in Danshen medicinal materials by near-infrared spectroscopy

[0157] Step 1: After the Danshen medicinal material is crushed, pass through a 50-mesh medicinal material standard sieve, mix well, and seal it for later use;

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Abstract

The invention provides a method for using a near infrared spectroscopy to measure contents of multiple components in a radix et rhizoma salviae miltiorrhizae medicinal material and application feasibility of the method in a Chinese patent medicine raw material quality assurance system is discussed. The method comprises the steps: utilizing a high performance liquid chromatography to measure contents of danshinolic acid B, rosmarinic acid, alkannic acid, tanshinone IIA, tanshinone I and cryptotanshinone in radix et rhizoma salviae miltiorrhizae as contrast values; utilizing near infrared diffusion reflection method to collect a sample spectrum, comparing different spectrum pretreating methods and modeling effects of modeling waveband and optimizing modeling parameters; utilizing a partial least squares (PLS) to respectively establish near infrared quantitative analysis models of danshinolic acid B, rosmarinic acid, alkannic acid and tanshinone components (tanshinone IIA plus tanshinoneI plus cryptotanshinone) in the radix et rhizoma salviae miltiorrhizae and evaluating the models. The quantitative analysis models established by the method disclosed by the invention can meet a requirement of quickly obtaining chemical information of massive radix et rhizoma salviae miltiorrhizae medicinal material samples.

Description

technical field [0001] The invention relates to a method for detecting components of traditional Chinese medicines, in particular to a method for determining the content of multiple components in Danshen medicinal materials by using near-infrared spectroscopy. Background technique [0002] Salvia miltiorrhiza is a commonly used traditional Chinese medicine with a long history of application, and it is also an important natural resource. Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bge. The chemical composition of Danshen is mainly divided into water-soluble components and fat-soluble components, among which: the water-soluble components of Danshen are mainly phenolic acids, and salvianolic acid B is one of the test substances for the content determination items of the Chinese Pharmacopoeia in the 2010 edition; the fat-soluble components of Danshen Most of the components are conjugated quinones and ketones, and the ones with higher content are tansh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N21/3563G01N30/88
CPCG01N21/3563G01N21/359G01N30/88G01N2030/8809
Inventor 章顺楠叶正良周立红熊皓舒李真齐敏超周磊斌
Owner TIANJIN TASLY PHARMA CO LTD
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