A kind of breeding method of raw material rabbit strain of swine fever spleen drench vaccine

Abstract

The invention relates to a breeding method of raw material strains for hog cholera spleen and lymph vaccines. PL30 breeding rabbit flocks with stable hereditary characters can be bred by improving Belgian rabbits introduced from Renna, Italy, and then through induction of the 29th generation of hog cholera lapinised viruses, the rabbits can make the hog cholera lapinised viruses efficiently propagated in vivo. PL30 bucks serve as male parents of great-grandparent generations, Japanese white rabbits with large ears serve as female parents of the great-grandparent generations, and the PL30 bucksand the Japanese white rabbits are hybridized to obtain F1 generations; then rex rabbits serve as male parents of grandparent generations, hybridized maternal rabbits of the F1 generations serve as female parents of the grandparent generations, and the rex rabbits and the hybridized maternal rabbits are hybridized to obtain F2 generations of hybridized colonies; then the F2 generations of hybridized colonies serve as parent generations and are subjected to four generations of crossing fixation to obtain the needed strains. The new strains of rabbits bred by means of the method have large grams of spleens and mesenteric lymphonodi, are more suitable for making the hog cholera lapinised viruses propagated in vivo, the utilization rate is 90% or above, the strains are very suitable for serving as raw material rabbits for producing vaccines for the hog cholera lapinised viruses, and the popularizing value is high.

Description

technical field [0001] The invention belongs to the method of animal hybrid breeding. In particular, it relates to a method for cultivating raw material rabbits for swine fever spleen drenched vaccine. The strain bred by the method is suitable for the propagation of the attenuated hog fever rabbit virus in the body, the utilization rate is more than 90%, and the spleen and intestinal lymph nodes are large in grams. Background technique [0002] There are many varieties of rabbits. According to statistics, there are about 45 purebred rabbit varieties in the world, which can be subdivided into edible rabbits, experimental rabbits, fur rabbits and pet rabbits. [0003] Spleen drenching vaccine for swine fever is currently one of the most effective defense measures against swine fever virus. Inoculating pigs with drenching swine fever spleen vaccine can reduce tens of billions of economic losses for the country every year. In my country, there are many rabbits used as raw mate...

AI Technical Summary

Problems solved by technology

The susceptibility of rabbits to CSFV and the size of spleen and intestinal lymph nodes are one of the most important factors affecting the yield of CSF spleen lymphoid vaccine. However, after years of production practice, it has been found that the sensitivity of these rabbit species to CSFV varies Irregularity leads to unstable utilization rate, low spleen and intestinal lymph nodes, which makes the utilization rate of raw material rabbits low in the production process, resulting in low vaccine production and greatly increasing the cost of using raw material rabbits

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