Application of Licorice Isoflavan A in the Preparation of Drugs for Treating Depression

A licorice isoflavane first, antidepressant technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc. effect of time

Active Publication Date: 2019-03-19
南京道尔医药研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above information suggests that it is feasible to screen natural medicines with antidepressant effects from licorice flavonoids, but there is no research on licorice isoflavan A as an antidepressant in animal disease models or clinical application

Method used

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  • Application of Licorice Isoflavan A in the Preparation of Drugs for Treating Depression
  • Application of Licorice Isoflavan A in the Preparation of Drugs for Treating Depression
  • Application of Licorice Isoflavan A in the Preparation of Drugs for Treating Depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Study on TST Experiment of Glycyrrhizae Isoflavan A on Mice

[0023] 1. Experimental method

[0024] The FST experiments in mice were administered continuously for 4 days, and administered once a day by intragastric administration. Behavioral testing was performed 1h after the last administration. Each drug treatment was divided into control group, licorice isoflavan A (gastric administration) different dosage groups (20, 40, 60mg / kg, gastric administration) and imipramine hydrochloride tablet group (positive control group, 18mg / kg, orally administered). 10 mice per group. Put the mice into a circular glass container with a height of 20 cm, a diameter of 12 cm, and a water depth of 10 cm, at a water temperature of 25° C., observe for 6 min, and record the cumulative immobility time after 4 min. The criterion for judging immobility is that the animal stops struggling in the water and is in a floating state, with only small limb movements to keep the head ...

Embodiment 2

[0027] Example 2: Study on the FST Experiment of Glycyrrhizae Isoflavan A on Mice

[0028] 1. Experimental method

[0029] The FST experiments in mice were administered continuously for 4 days, and administered once a day by intragastric administration. Behavioral testing was performed 1h after the last administration. Each drug treatment was divided into control group, licorice isoflavan A (gastric administration) different dosage groups (20, 40, 60mg / kg, gastric administration) and imipramine hydrochloride tablet group (positive control group, 18mg / kg, orally administered). 10 mice per group. The tail suspension box is 25×25×25 cm, and the center rope of the top plate is connected with a small clip. Stick the adhesive tape to the tail end of the mouse at 2 cm, clamp the adhesive tape with the clip, and make the mouse hang upside down, with the head about 2 cm away from the bottom of the tail suspension box. 5cm, observe for 6min, and record the cumulative immobility tim...

Embodiment 3

[0032] Example 3: Study on the Regulation of Glycyrrhizae Isoflavan A on Mouse AMPA Receptor and BDNF-TrkB Signaling Pathway

[0033] 1. Experimental grouping

[0034] Select healthy male mice with an initial weight of 25-28g, and feed them adaptively for 1 week. During this period, sugar water training and opening experiments are carried out. The Morris water maze is used to screen the mice for learning and memory 1 day before modeling, with two rounds within 1 min. Those who find the platform are qualified, otherwise they will be eliminated. Mice were randomly divided into normal control group (normal drinking and eating, without any stimulation), CUMS model group, CUMS+licorice isoflavan A group (40mg / kg), CUMS+imipramine hydrochloride group, 10 in each group. Strictly control the feeding conditions and keep the temperature and humidity constant. Oral administration before stress every morning.

[0035] 2. Establishment of chronic stress model in mice

[0036] According t...

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PUM

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Abstract

The invention discloses application of licorisoflavan A in preparation of drugs for treating depression. Licorisoflavan A is a flavonoid compound separated from a Chinese herb, namely radix glycyrrhizae; the immobilization time of a mouse forced swimming test and tail suspension test of a chronic unpredictable mild stress depression model can be obviously shortened, it is indicated that licorisoflavan A has an excellent anti-depression effect, and by regulating and controlling AMPA receptors, a BDNF-TrkB passage can be adjusted to achieve the anti-depression effect. Licorisoflavan A can be combined with auxiliary agents, used for preparing the drugs for treating depression and applied with other anti-depression drugs.

Description

technical field [0001] The invention relates to the application of licorice isoflavan A, an active ingredient of the traditional Chinese medicine licorice, in the preparation of medicines for treating depression, and belongs to the field of traditional Chinese medicines. Background technique [0002] Depression, also known as "emotional cold", is a common emotional disorder mental disease, characterized by a significant and persistent low mood, clinical manifestations of depressed mood, loss of various interests and happiness, and often Accompanied by physical symptoms such as abnormal sleep, loss of appetite, weight loss, loss of libido, and even extreme behaviors such as suicide. With the intensification of competition, the incidence of depression is increasing, and it has gradually become a major disease that plagues human beings. According to WHO prediction, depression will become the second largest human disease by 2020, accounting for 5.7% of the total disease burden,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P25/24
CPCA61K31/353A61P25/24
Inventor 王琦成小兰葛驰宇陶伟伟陈荣刘睿
Owner 南京道尔医药研究院有限公司
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