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Preparation method and application of water-soluble phthalocyanine nanomaterial with high light-to-heat conversion efficiency

A nano-material and thermal conversion technology, which is applied in the field of nano-materials and medical materials, can solve the problems of unsatisfactory photothermal effect of phthalocyanine materials and difficulty in product purification, and achieve high photothermal conversion efficiency, good water solubility, and easy purification separation effect

Active Publication Date: 2019-12-17
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the currently published literature (such as CN102675625A, CN103539799A, CN104311566A, CN105294707A, etc.), the water-soluble modification process for phthalocyanine often involves complex chemical reactions and synthesis steps, and product purification is relatively difficult, and the final phthalocyanine material The photothermal effect is still not ideal

Method used

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  • Preparation method and application of water-soluble phthalocyanine nanomaterial with high light-to-heat conversion efficiency
  • Preparation method and application of water-soluble phthalocyanine nanomaterial with high light-to-heat conversion efficiency
  • Preparation method and application of water-soluble phthalocyanine nanomaterial with high light-to-heat conversion efficiency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Weigh 100 mg of ZnPc and disperse it in 50 mL of ethanol under the action of ultrasound to obtain an ethanol solution of ZnPc. Weigh 2.0 g of citric acid and dissolve it in 50 mL of purified water to obtain an aqueous solution of citric acid. The ethanol solution of ZnPc was slowly added dropwise to the aqueous solution of citric acid, and ultrasonic was added while dropping, and the dropping process continued for 30 minutes. Then put the beaker containing the mixed solution into an oil bath and heat it up to 120° C. to react for about 1 hour, then raise the temperature of the mixed solution to 220° C. to evaporate the solvent to dryness. Add about 1 mL of purified water to the solid obtained by evaporating to dryness to dissolve completely, then heat to the same temperature and evaporate to dryness, repeat adding water-evaporating to dryness 8-10 times, and this process lasts for about 3 hours. After cooling the product obtained by evaporating to dryness, dissolve it ...

Embodiment 2

[0041] This embodiment is basically the same as Embodiment 1, except that ZnPc is replaced by MnPc.

Embodiment 3

[0043] This embodiment is basically the same as Embodiment 1, except that ZnPc is replaced by CoPc.

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Abstract

The invention discloses a novel water-soluble phthalocyanine nano material with high photothermal conversion efficiency and a preparation method and application. The phthalocyanine nano material is prepared through different tetraaminophthalocyanine compounds and polycarboxylic compounds by molecule self-assembling and hydrothermal method. Compared with an existing photo-thermal material, the phthalocyanine nano material has the characteristics of being high in photothermal conversion efficiency, simple in preparation method, time saving, and simple to purify; the raw materials for the hydrothermal method are wide in source; the tetraaminophthalocyanine compounds are simple to synthesize; the prepared phthalocyanine nano material is outstanding in photothermal performance, is obvious in photothermal treatment effect to tumor cells, and is high in application potential in tumor photothermal treatment agents.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and medical materials, in particular to a water-soluble phthalocyanine nanomaterial with high light-to-heat conversion efficiency, its preparation method and its application in medical treatment. Background technique [0002] Photothermal therapy is an emerging cancer treatment method, which has the advantages of high selectivity and minimal invasiveness. During photothermal therapy, nanomaterials reach tumor cells or tumor tissues through the EPR effect (enhanced permeability and retention effect, high permeability and retention effect). Elevation can induce the dysfunction of various biological enzymes in cancer cells, and eventually lead to the death of cancer cells. Excellent photothermal nanomaterials not only have strong absorption in the near-infrared region, but also have high photothermal conversion efficiency, and must also have the advantages of low biological toxicity, good phot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D487/22A61K41/00A61P35/00
CPCA61K41/0052A61P35/00C07D487/22
Inventor 吴风收乐亮亮朱训进王凯
Owner WUHAN INSTITUTE OF TECHNOLOGY