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Preparation method and application of double salt formed by inosine and matrine or oxymatrine
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A technology of matrine and matrine, which is applied in the field of medicine, can solve the problems of poor therapeutic effect, large dosage, and single chemical composition, and achieve the effects of reducing dosage, simple preparation method, and improving drug efficacy
Inactive Publication Date: 2018-11-06
刘兆平
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Embodiment 1
[0031] A kind of preparation method of the double salt that is formed by inosine and matrine as follows, concrete steps are as follows:
[0032] (1) Add the mixture of inosine and matrine into methanol, stir and reflux at 20°C until clarification;
[0033] (2) evaporating and concentrating the clear liquid obtained in step (1) at 40°C;
[0034] (3) After cooling the concentrated product, filter, wash, and dry under reduced pressure at -0.09MPa;
[0035]
[0036] where x=1, y=1, z=0.
Embodiment 2
[0038] A kind of preparation method of the double salt that is formed by inosine and matrine as follows, concrete steps are as follows:
[0039] (1) Add the mixture of inosine and matrine into ethanol, stir and reflux at 40°C until clarified;
[0040] (2) evaporating and concentrating the clear liquid obtained in step (1) at 60°C;
[0041] (3) Filter the concentrated product after cooling, wash, and dry under reduced pressure at -0.05MPa;
[0042]
[0043] where x=1, y=0, z=1.
Embodiment 3
[0045] A kind of preparation method of the double salt that following formula is formed by inosine, matrine and matrine, concrete steps are as follows:
[0046] (1) Add the mixture of inosine, matrine and matrine in methanol, stir and reflux at 60°C until clarification;
[0047] (2) evaporating and concentrating the clear liquid obtained in step (1) at 80°C;
[0048] (3) After cooling the concentrated product, filter, wash, and dry under reduced pressure at -0.01MPa;
[0049]
[0050] where x=1, y=1, z=1.
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Abstract
The invention discloses a preparation method of double salt formed by inosine and matrine and / or oxymatrine. The method comprises the following steps that a mixture of the inosine and the matrine and / or the oxymatrine is added into organic solvent and subjected to stirring and reflux at 20-60 DEG C until clear; obtained clear liquid is subjected to evaporation and concentration at 40-80 DEG C; a concentrated product is cooled, filtered, washed and dried under reduced pressure at -0.09 to -0.01 MPa. The invention further discloses a medicine composition containing the double salt and pharmaceutically-acceptable accessories. The medicine composition is used for treating inflammation, cardiovascular and cerebrovascular diseases and senile dementia. Animal experiments prove that the inosine and the matrine and / or the oxymatrine have a synergistic interaction effect, and the efficacy can also be improved under the situation of a reduced medicine dosage.
Description
technical field [0001] The present invention relates to a kind of preparation method and the use of double salt, be specifically related to a kind of preparation method and the use of the double salt that inosine and matrine or matrine form, belong to medicine field. Background technique [0002] Matrine and matrine are alkaloids isolated from the roots of Sophora flavescens or Sophorajaponica. In recent years, domestic and foreign studies on matrine and matrine have found that matrine not only has anti-hepatitisvirus, anti-hepatic fibrosis, immune regulation, anti-tumor, anti-inflammation, anti-allergic and many other effects. Pharmacological activity, also has obvious cardiotonic, anti-arrhythmia, lowering blood pressure, relieving asthma, scavenging free radicals, anti-radiation, sedative and analgesic effects, in addition, it is still used for the treatment of vaginitis, parasitic diseases (such as drops Insectosis, giardiasis, Juniperosis) and psoriasis, etc., are a ...
Claims
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