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Curcumin nano-emulsion and preparation method thereof

A technology of nanoemulsion and curcumin, applied in the field of curcumin nanoemulsion and preparation thereof, can solve the problems of easy degradation, sensitivity to light, and difficulty in absorption, and achieve the effects of improving absorption efficiency, improving stability, and large specific surface area.

Inactive Publication Date: 2018-11-13
赵玉林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, curcumin has poor water solubility, is difficult to absorb in the body, is easy to metabolize (low oral bioavailability, most of it is excreted in the original form), is sensitive to light, and is easy to degrade, which limits its clinical application.

Method used

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  • Curcumin nano-emulsion and preparation method thereof
  • Curcumin nano-emulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: add curcumin, lecithin in reactor, stir at normal temperature, the rotating speed of stirring is 50-80 rev / min, stir 1.5-2h, fully mix, then carry out ultrasonic treatment, ultrasonic treatment is that ultrasonic power is 300W, The ultrasonic frequency is 20KHZ, and the ultrasonic time is 30min, then gelatin is added and mixed to obtain a curcumin nanoemulsion with a content of 1% curcumin, 5% lecithin and 2% gelatin.

Embodiment 2

[0016] Embodiment 2: the curcumin nanoemulsion component is 5% curcumin, 10% alkylphenol polyoxyethylene ether and 3% sodium caseinate, and all the other are the same as embodiment 1.

Embodiment 3

[0017] Embodiment 3: The curcumin nanoemulsion component is 10% curcumin, 15% Tween 80 and 3% agar, all the other are the same as embodiment 1.

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Abstract

The invention relates to curcumin nano-emulsion and a preparation method thereof. The curcumin nano-emulsion comprises, in weight percent, 1-20% of curcumin, 5-15% of surface active agents and 2-3% ofthickening agents. The preparation method of the curcumin nano-emulsion includes the steps: (1) adding active components and the surface active agents into a reaction kettle, stirring mixture for 1.5-2h at the normal temperature at the rotating speed of 50-80 revolutions / min, and sufficiently mixing the mixture; (2) ultrasonically treating the mixture acquired in the step (1), adding the thickening agents, stirring mixture to obtain the curcumin nano-emulsion.

Description

technical field [0001] The invention relates to the field of chemical preparations, in particular to a curcumin nanoemulsion and its preparation. Background technique [0002] Curcumin is a phenolic compound extracted from turmeric, a plant of the Zingiberaceae family, which has anti-oxidation, anti-tumor, anti-inflammatory, anti-HIV, hypolipidemic, and anti-atherosclerotic effects. However, curcumin has poor water solubility, is difficult to absorb in the body, is easy to metabolize (low oral bioavailability, most of it is excreted in the original form), is sensitive to light, and is easy to degrade, which limits its clinical application. In recent years, the research on curcumin has become increasingly active. As an insoluble drug with good application prospects, it has become a hot topic in current research to improve its bioavailability and prolong the action time through the development and research of dosage forms. [0003] Nanoemulsion has attracted much attention du...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/12A61K47/24A61K47/10A61K47/26A61P35/00
CPCA61K9/1075A61K31/12A61K36/9066A61K47/10A61K47/24A61K47/26
Inventor 赵玉林
Owner 赵玉林
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