Application of dalbergia pinnata essential oil to preparation of medicine for treating or preventing ulcerative colitis

A technology of ulcerative colitis and sandalwood essential oil, which is applied in the field of medicine, can solve the problems of ulcerative colitis without oblique leaf sandalwood, achieve the effect of reducing disease activity index and inhibiting weight loss

Active Publication Date: 2018-11-13
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far there is no public report on the application of sandalwood oblique leaf in the treatment of ulcerative colitis or the preparation of medicines for treating ulcerative colitis

Method used

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  • Application of dalbergia pinnata essential oil to preparation of medicine for treating or preventing ulcerative colitis
  • Application of dalbergia pinnata essential oil to preparation of medicine for treating or preventing ulcerative colitis
  • Application of dalbergia pinnata essential oil to preparation of medicine for treating or preventing ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The present embodiment provides the preparation method of oblique sandalwood essential oil, and the steps are as follows:

[0033] Take by weighing 5000g of oblique-leaved sandalwood, pass through a 60-mesh sieve after pulverizing, and add the obtained medicinal material powder into supercritical CO 2 In the extraction kettle, the pressure of supercritical extraction is adjusted to 25Mpa, the extraction temperature is 60°C, and the extraction time is 180min, and the extraction is performed. The obtained extract is collected, placed in an ultrafiltration device for filtration, and the obtained microfiltration material is collected to obtain the Sandalwood oblique leaf essential oil of the present invention.

Embodiment 2

[0035] The present embodiment provides the preparation method of oblique sandalwood essential oil, and the steps are as follows:

[0036] Take by weighing 5000g of oblique-leaved sandalwood, pass through a 60-mesh sieve after pulverizing, and add the obtained medicinal material powder into supercritical CO 2 In the extraction kettle, the pressure of the supercritical extraction is adjusted to 22Mpa, the extraction temperature is 55°C, and the extraction time is 170min, and the extraction is performed. The obtained extract is collected, placed in an ultrafiltration device for filtration, and the obtained microfiltration material is collected to obtain the Sandalwood oblique leaf essential oil of the present invention.

Embodiment 3

[0038] The present embodiment provides a kind of preparation method of oblique sandalwood essential oil emulsion, and the steps are as follows:

[0039] Take 250 mL of Sandalwood essential oil from Example 1, grind it with 75 g of gum arabic, add 125 mL of distilled water at one time, grind to make colostrum, then slowly add 3.5 g of tragacanth gum into the glue, add distilled water to 500 mL, and stir well , that is, oblique sandalwood essential oil emulsion.

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Abstract

The invention provides application of dalbergia pinnatad essential oil to preparation of a medicine for treating or preventing ulcerative colitis. The essential oil can effectively inhibit DSS (dextran sulphate sodium) from inducing loss of weight of mice suffering from ulcerative colitis, reduce the disease activity index of the mice suffering from DSS induced ulcerative colitis, improve the overall score of the colon tissue and has the effect more excellent than that of the existing clinical medicine SASP (salazosulfapyridine) for ulcerative colitis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of oblique sandalwood essential oil in the preparation of medicines for treating or preventing ulcerative colitis. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC) is a chronic non-specific colonic inflammatory disease characterized by abdominal pain, diarrhea, mucus, pus and blood. life and health. Commonly used clinical therapies mainly include the use of aminosalicylic acid drugs such as mesalamine, sulfasalazine (SASP) and balsalazide, hormone drugs such as prednisone, and immunosuppressant drugs such as acetazolamide and methylamine. Pterin, etc., probiotics are used as adjuvant drugs such as Bifikon, Beifeida, Lactobacillus Tablets and Livzon Changle; in addition, anti-adhesion molecular therapy and biological therapy have also achieved certain clinical effects, improving intestinal microbiome. Cycle therapy has achiev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P1/00A61P1/04
CPCA61K36/48A61K2236/37A61P1/00A61P1/04
Inventor 张丹雁熊清平李世杰林如意叶贤英
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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