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Method to precisely control iron-loading capacity of iron protein succinylate

A technology of iron protein succinate and precise control, which is applied in the field of medicine, can solve the problems of large measurement work, tedious work, and the inability to accurately quantify the iron content of iron protein succinate, and achieve the effect of stable quality, simple process, and avoiding measurement work

Inactive Publication Date: 2018-11-13
湖北华世通生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The first object of the present invention is to provide a method for accurately controlling the iron content of iron protein succinate. The method for accurately controlling the iron content of iron protein succinate solves the problem in the prior art that the iron content can only be controlled by The problem of estimating a large range of pH value and being unable to accurately quantify the iron loading amount of iron protein succinate, this method can accurately quantify the iron loading amount of iron protein succinate through the calculation formula, avoiding tedious and large error measurement work , the error is not more than ±1%

Method used

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  • Method to precisely control iron-loading capacity of iron protein succinylate

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Effect test

Embodiment 1

[0071] Disperse 37.5g of casein (loss on drying: 8.76%) in 250g of purified water, add 8.5g of 4N sodium hydroxide solution dropwise after raising the temperature to 60°C to keep the system pH=7-9 to fully dissolve the casein, then divide more Add 5.5g of succinic anhydride in batches and at the same time dropwise add 30.0g of 4N sodium hydroxide solution to keep the system pH=5-7. The hydrochloric acid solution maintains the pH of the system at 2.0-3.0 to precipitate solids. After centrifugation, the obtained solids are added to an appropriate amount of 250 g of purified water, beaten at room temperature for 1-3 hours, and then centrifuged to obtain 240 g of wet succinyl casein.

[0072] Take 240g of the above wet product of succinyl casein and disperse it in 500g of purified water. After raising the temperature to 60°C, add 41.5g of 4N sodium hydroxide solution dropwise to maintain the system pH=7-9 to fully dissolve the succinyl casein, and then filter to remove a small amou...

Embodiment 2

[0075] Disperse 37.5g of casein (loss on drying: 8.76%) in 250g of purified water, add 8.5g of 4N sodium hydroxide solution dropwise after raising the temperature to 60°C to keep the system pH=7-9 to fully dissolve the casein, then divide more Add 5.5g of succinic anhydride in batches and at the same time dropwise add 30.0g of 4N sodium hydroxide solution to keep the system pH=5-7. The hydrochloric acid solution maintains the pH of the system at 2.0-3.0 to precipitate solids. After centrifugation, the obtained solids are added to an appropriate amount of 250 g of purified water, beaten at room temperature for 1-3 hours, and then centrifuged to obtain 240 g of wet succinyl casein.

[0076] Take 240g of the above wet product of succinyl casein and disperse it in 500g of purified water. After raising the temperature to 60°C, add 41.5g of 4N sodium hydroxide solution dropwise to maintain the system pH=7-9 to fully dissolve the succinyl casein, and then filter to remove a small amou...

Embodiment 3

[0079] Disperse 1.50kg of casein (loss on drying: 8.76%) in 10.00kg of purified water, add 0.34kg of 4N sodium hydroxide solution dropwise after heating up to 60°C to keep the system pH=7-9 to fully dissolve the casein, then divide Add 0.22kg of succinic anhydride in multiple batches and dropwise add 1.16kg of 4N sodium hydroxide solution to keep the pH of the system at 5-7. 4N hydrochloric acid solution kept the pH of the system at 2.0-3.0 to precipitate solids. After centrifugation, the resulting solids were added to an appropriate amount of 16.00 kg of purified water, beaten at room temperature for 1-3 hours, and then centrifuged to obtain 4.48 kg of wet succinyl casein.

[0080] Take 4.48kg of the above wet product of succinyl casein and disperse it in 10.00kg of purified water. After raising the temperature to 60°C, add 0.79kg of 4N sodium hydroxide solution dropwise to keep the system pH=7-9 to fully dissolve the succinyl casein, and then remove it by filtration. A small...

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Abstract

The invention provides a method to precisely control iron-loading capacity of iron protein succinylate. The iron-loading capacity of iron protein succinylate can be accurately and quantitatively determined through a calculation formula; the iron-loading capacity of iron protein succinylate may reach 15%; the method has good simplicity, good dissolubility and good quality stability. The method according to the application prevents complex measurements with large error, and the error is not higher than + / -1%.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for precisely controlling the amount of iron loaded in iron protein succinate. Background technique [0002] Iron is one of the essential elements that make up the human body. Iron deficiency will affect the health and development of the human body. The biggest impact is iron deficiency anemia. According to the survey of the World Health Organization, about 50% of girls, 20% of adult women, and 40% of pregnant women will suffer from iron deficiency anemia. Iron supplementation is the process of supplementing the human body with necessary and appropriate amounts of inorganic iron or organic iron compounds through food or special nutrients, so as to supplement iron elements to achieve the purpose of strengthening the body, preventing or assisting the treatment of diseases. Iron supplementation is the process of supplementing the human body with necessary and appropriate ...

Claims

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Application Information

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IPC IPC(8): C07K14/47C07K1/14C07K1/02
CPCC07K14/4732C07K19/00
Inventor 徐有安崔健王火箭项斌杭健赵阿龙
Owner 湖北华世通生物医药科技有限公司
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