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Preparation method of medlar, chrysanthemum and rehmannia oral solution

A technology of Rehmannia glutinosa oral liquid and filtrate, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of easy precipitation and the like

Inactive Publication Date: 2018-11-20
JIANGXI JIMINKEXIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Qiju Dihuang Oral Liquid prepared by the existing technology is prone to precipitation during storage, so try to use new technologies and new excipients to improve stability, reduce precipitation, and improve clarity

Method used

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  • Preparation method of medlar, chrysanthemum and rehmannia oral solution
  • Preparation method of medlar, chrysanthemum and rehmannia oral solution
  • Preparation method of medlar, chrysanthemum and rehmannia oral solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1: A preparation method for improving the clarity of Qiju Dihuang Oral Liquid

[0059] Weigh the medicinal materials and raw and auxiliary materials according to the prescription quantity:

[0060]

[0061] Chrysanthemum and peony cortex are distilled with water steam, and an appropriate amount of distillate is collected and stored in another container; the dregs of the medicine are decocted in water for 1.5 hours, filtered, and the filtrate is used for later use. Lycium barbarum, Rehmannia glutinosa, Cornus officinalis, Chinese yam, and Alisma, add water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine the filtrates, and filter. Combine the filtrate with the decoction of chrysanthemum and peony cortex, concentrate until the specific gravity of the clear paste is 1.1, let it cool, add 95% ethanol to make the alcohol content reach 80%, stir well, adjust the pH to 3.5, let stand for 24 hours, filter , recovery of ethanol. P...

Embodiment 2

[0062] Example 2: A preparation method for improving the clarity of Qiju Dihuang Oral Liquid

[0063] Weigh the medicinal materials and raw and auxiliary materials according to the prescription quantity:

[0064]

[0065] Chrysanthemum and peony cortex are distilled with water steam, and an appropriate amount of distillate is collected and stored in another container; the dregs of the medicine are decocted in water for 1.5 hours, filtered, and the filtrate is used for later use. Lycium barbarum, Rehmannia glutinosa, Cornus officinalis, Chinese yam, and Alisma, add water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine the filtrates, and filter. Combine the filtrate with the water decoction of chrysanthemum and peony cortex, concentrate until the specific gravity of the clear paste is 1.15, let it cool, add 95% ethanol to make the alcohol content reach 80%, stir well, adjust the pH to 3.5, let stand for 24 hours, filter , recovery of etha...

Embodiment 3

[0066] Example 3: A preparation method for improving the clarity of Qiju Dihuang Oral Liquid

[0067] Weigh the medicinal materials and raw and auxiliary materials according to the prescription quantity:

[0068]

[0069] Chrysanthemum and peony cortex are distilled with water steam, and an appropriate amount of distillate is collected and stored in another container; the dregs of the medicine are decocted in water for 1.5 hours, filtered, and the filtrate is used for later use. Lycium barbarum, Rehmannia glutinosa, Cornus officinalis, Chinese yam, and Alisma, add water and decoct twice, the first time for 2 hours, the second time for 1.5 hours, combine the filtrates, and filter. Combine the filtrate with the water decoction of chrysanthemum and peony cortex, concentrate until the specific gravity of the clear paste is 1.2, let it cool, add 95% ethanol to make the alcohol content reach 80%, stir well, adjust the pH to 3.5, let stand for 24 hours, filter , recovery of ethan...

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Abstract

The invention relates to a preparation method of a medlar, chrysanthemum and rehmannia oral solution. The medlar, chrysanthemum and rehmannia oral solution adopts a formula as follows: 33g of medlar,33g of chrysanthemum, 130g of prepared rehmannia, 65g of dogwood (prepared), 50g of moutan bark, 65g of Chinese yam, 50g of poria cocos and 50g of rhizoma alismatis. The preparation method comprises the following steps: distilling the chrysanthemum and the moutan bark by using steam, collecting a proper amount of distillate, adding medicinal dreg into water, decocting for 1.5 hours, filtering, collecting a filtrate for use, adding the medlar, the prepared rehmannia, the dogwood, the Chinese yam and the rhizoma alismatis into water, decocting, combing filtrates, combining the filtrate with a decoction of the chrysanthemum and the moutan bark, concentrating, adding ethanol to adjust the ph to 3.5-5.5, standing, filtering, recycling the ethanol, adding the poria cocos into water, decocting, filtering, concentrating, combining decoctions, and blending to obtain the medlar, chrysanthemum and rehmannia oral solution.

Description

technical field [0001] The invention relates to the technical field of medicine processing, in particular to the technical field of improving the stability and clarity of Qiju Dihuang Oral Liquid. technical background [0002] Qiju Dihuang Oral Liquid is a modified dosage form of Qiju Dihuang Pills. The formula is as follows: Lycium barbarum 33g, Chrysanthemum 33g, Rehmannia glutinosa 130g, Cornus officinalis (made) 65g, Cortex Moutan 50g, Chinese yam 65g, Poria cocos 50g, Alisma 50g, Qiju Dihuang oral The liquid is a mixture of nourishing the kidney and nourishing the liver. It is used for dizziness, tinnitus, astringent eyes, photophobia, and dim vision caused by liver and kidney yin deficiency. [0003] The preparation method of the existing Qiju Dihuang oral liquid is as follows: distill chrysanthemum and peony cortex with water steam, collect an appropriate amount of distillate, and store it in another container; decoct the dregs of the medicine for 1.5 hours, filter, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/08A61K47/12A61P1/14A61P27/02A61P27/16
CPCA61K9/0095A61K36/076A61K36/287A61K36/40A61K36/65A61K36/71A61K36/804A61K36/815A61K36/884A61K36/8945A61K47/12A61K2236/331A61K2236/39A61K2236/55A61P1/14A61P27/02A61P27/16A61K2300/00
Inventor 翟凤彭常春邹武斌张克勤何平清
Owner JIANGXI JIMINKEXIN PHARMA