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Coating technology of pancreatic kininogenase enteric-coated tablets

A pancreatic kininogenase, enteric-coated tablet technology, applied in the directions of peptidase, enzyme, hydrolase, etc., can solve the problems of appearance, dissolution, reduced stability, instability, easily affecting product quality, etc. Complete, stable, high dissolution effect

Inactive Publication Date: 2018-11-23
CHENGDU TONGDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The raw material drug of pancreatic kininogenase enteric-coated tablets is a biochemical enzyme, which is easily degraded and unstable during production and storage. Especially in the production process, the coating process is a very important process parameter. The existing The coating process of pancreatic kininogenase enteric-coated tablets is likely to affect the quality of the product, resulting in a decrease in its appearance, dissolution rate, and stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: A kind of coating process of pancreatic kininogenase enteric-coated tablet comprises the following steps:

[0021] Step 1. Prepare materials according to the mass parts of the following components: 100 parts of plain tablets, 1.5 parts of gastric-soluble film-coating premixed auxiliary materials, and 5 parts of enteric-soluble film-coated premixed auxiliary materials;

[0022] Step 2. Add 80% ethanol (80% ethanol is made with 95% ethanol plus purified water) to the stomach-soluble film coating premixed auxiliary material in the formula amount in step 1 and stir evenly in a pulping pot or stainless steel bucket to prepare 10% gastric-soluble film-coating premixed adjuvant solution; add 80% ethanol to the enteric-coated film-coated premixed adjuvant in step 1 (80% ethanol is made from 95% ethanol plus purified water) Stir evenly in a pulping pot or stainless steel bucket to make an enteric-coated film-coating premixed auxiliary material solution with a conce...

Embodiment 2

[0030] Embodiment 2: a kind of coating process of pancreatic kininogenase enteric-coated tablet, comprises the following steps:

[0031] Step 1. Prepare materials according to the mass parts of the following components: 100 parts of plain tablets, 2 parts of gastric-soluble film-coating premixed auxiliary materials, and 5.5 parts of enteric-soluble film-coated premixed auxiliary materials;

[0032] Step 2. Add 80% ethanol (80% ethanol is made with 95% ethanol plus purified water) to the stomach-soluble film coating premixed auxiliary material in the formula amount in step 1 and stir evenly in a pulping pot or stainless steel bucket to prepare 10% gastric-soluble film-coating premixed adjuvant solution; add 80% ethanol to the enteric-coated film-coated premixed adjuvant in step 1 (80% ethanol is made from 95% ethanol plus purified water) Stir evenly in a pulping pot or stainless steel bucket to make an enteric-coated film-coating premixed auxiliary material solution with a conc...

Embodiment 3

[0040] Embodiment 3: a kind of coating process of pancreatic kininogenase enteric-coated tablet comprises the following steps:

[0041] Step 1. Prepare materials according to the mass parts of the following components: 100 parts of plain tablets, 2.5 parts of gastric-soluble film-coating premixed auxiliary materials, and 6 parts of enteric-soluble film-coated premixed auxiliary materials;

[0042]Step 2. Add 80% ethanol (80% ethanol is made with 95% ethanol plus purified water) to the stomach-soluble film coating premixed auxiliary material in the formula amount in step 1 and stir evenly in a pulping pot or stainless steel bucket to prepare 10% gastric-soluble film-coating premixed adjuvant solution; add 80% ethanol to the enteric-coated film-coated premixed adjuvant in step 1 (80% ethanol is made from 95% ethanol plus purified water) Stir evenly in a pulping pot or stainless steel bucket to make an enteric-coated film-coating premixed auxiliary material solution with a concen...

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PUM

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Abstract

The invention discloses a coating technology of pancreatic kininogenase enteric-coated tablets. The coating technology comprises the following steps: pouring tablets into a roller of a coating machine; adding a gastric dissolving type thin film coated pre-mixed auxiliary material solution and carrying out first-time coating; then adding an enteric dissolving type thin film coated pre-mixed auxiliary material solution and carrying out second-time coating and cooling to obtain the pancreatic kininogenase enteric-coated tablets. After the pancreatic kininogenase enteric-coated tablets are coated,complete appearance, high dissolution and good stability of the pancreatic kininogenase enteric-coated tablets can be ensured, so that the curative effect of medicines is improved.

Description

technical field [0001] The invention belongs to the technical field of drug coating technology, in particular to a coating technology of pancreatic kininogenase enteric-coated tablets. Background technique [0002] The raw material drug of pancreatic kininogenase enteric-coated tablets is a biochemical enzyme, which is easily degraded and unstable during production and storage. Especially in the production process, the coating process is a very important process parameter. The existing The coating process of pancreatic kininogenase enteric-coated tablets is likely to affect the quality of the product, resulting in a decrease in its appearance, dissolution rate, and stability. Contents of the invention [0003] In order to solve the above-mentioned problems in the prior art, the present invention provides a coating process for pancreatic kininogenase enteric-coated tablets. After the pancreatic kininogenase enteric-coated tablet is coated by this process, it can ensure tha...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K38/48
CPCA61K9/2886A61K9/2893A61K38/482C12Y304/21035
Inventor 梁星关锋张利蓉
Owner CHENGDU TONGDE PHARMA
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