Preparation method of regenerated medical material for bone and soft tissue bonding and restoration

A medical material and soft tissue technology, applied in the field of regenerative medical material preparation, can solve the problems of large production line investment, inability to form porous materials, difficult materials to be highly compatible, and expanded functions

Inactive Publication Date: 2018-11-23
北京幸福益生高新技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) The degradation rate is slow, and it usually takes 1-2 years for complete degradation
[0006] (2) The pH value is unstable and may reach 11, forming a strong alkalinity with certain cytotoxicity
[0007] (3) The melting and quenching reaction temperature is very high, resulting in high energy consumption, and the establishment of a standard production line requires a large investment
[0008] (4) The current bioactive glass cannot form a porous material, and it is difficult to achieve a high degree of compliance and expand the function of the material

Method used

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  • Preparation method of regenerated medical material for bone and soft tissue bonding and restoration
  • Preparation method of regenerated medical material for bone and soft tissue bonding and restoration
  • Preparation method of regenerated medical material for bone and soft tissue bonding and restoration

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preparation example Construction

[0043] A method for preparing a regenerative medical material for bonding and repairing bone and soft tissue provided in this specification includes the following steps:

[0044] Step 1: mixing soybean bio-fermentation extract solution and ethyl tetrasilicate solution in a reaction kettle;

[0045] Step 2: Add absolute ethanol and water to the orthosilicate mixed solution of soybean biological fermentation extract, dissolve at room temperature and stir at a certain stirring frequency for a certain period of time to form a mixed solution;

[0046] Step 3: Slowly add calcium nitrate tetrahydrate powder into the mixed solution, stir evenly, add nitric acid solution, and stir to form a sol solution;

[0047] Step 4: Aging the solution at room temperature to form a gel;

[0048] Step 5: Dry the mixed gel at low temperature;

[0049]Step 6: Sintering the gel yields a regenerative medicine material that bonds and repairs bone and soft tissue.

[0050] The preparation method of the...

Embodiment 1

[0056] Preparation of Soybean Biological Fermentation Extract-tetraethyl orthosilicate Mixture

[0057] Weigh 80kg of tetraethyl orthosilicate to prepare 20% tetraethyl orthosilicate solution, weigh 3kg of soybean bio-fermentation extract to prepare 40% of soybean bio-fermentation extract, and place the two solutions in a sealed reaction kettle Inside, stir evenly at room temperature.

[0058] Sol solution preparation

[0059] Measure 200kg of 99.7% absolute ethanol, add 300ml of water, slowly add soybean bio-fermentation extract-orthosilicate mixture, and continue stirring at room temperature for 200min at a speed of 20r / min.

[0060] Calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O) 3kg of powder, the time is controlled to 5min, after stirring evenly, add 200ml of HNO3 solution, and continue stirring at room temperature for 40min at a speed of 20r / min to obtain a sol solution.

[0061] gel preparation

[0062] The above sol solution was aged at room temperature for 1 d...

Embodiment 2

[0068] Preparation of Soybean Biological Fermentation Extract-tetraethyl orthosilicate Mixture

[0069] Weigh 200kg of tetraethyl orthosilicate to prepare 30% tetraethyl orthosilicate solution, weigh 10kg of soybean bio-fermentation extract to prepare 60% of soybean bio-fermentation extract, and place the two solutions in a sealed reaction kettle Inside, stir evenly at room temperature.

[0070] Sol solution preparation

[0071] Measure 300kg of 99.7% absolute ethanol, add 1000ml of water, slowly add soybean bio-fermentation extract-orthosilicate mixture, and continue stirring at room temperature for 80min at a speed of 80r / min.

[0072] Calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O) Powder 10kg, time control is 10min, after stirring evenly, add 400ml of HNO 3 The solution was continuously stirred at room temperature for 40 min at a speed of 80 r / min to obtain a sol solution.

[0073] gel preparation

[0074] The above sol solution was aged at room temperature for 3 ...

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Abstract

The invention relates to a preparation method of a regenerated medical material for bone and soft tissue bonding and restoration. The method can be widely applied to the fields of artificial bones, degradable heart stents, wound healing promotion, scar reduction, scar restoration, mucosa restoration and the like. The method comprises the steps of preparing a mixed solution of butyl silicate and bean type biological fermentation extraction liquid; adding anhydrous alcohol and water into the mixed solution of butyl silicate and bean type biological fermentation extraction liquid; after the stirring for a certain time, slowly adding calcium salt; after the uniform stirring, adding an acid solution to obtain a sol solution; performing aging volatilization on the gel solution; performing low-temperature drying on the gel; then performing gradient sintering to obtain the regenerated medical material for bone and soft tissue bonding and restoration. The gradient low-temperature sintering modeis used; the sol-gel method is used for preparing the regenerated medical material for bone and soft tissue bonding and restoration; the bioactivity is higher; good biocompatibility and tissue restoration performance are realized; in addition, the preparation method is simple; the operation is easy; the cost is reduced; the popularization is easy.

Description

technical field [0001] The invention belongs to the technical field of inorganic materials and regenerative medical materials, and designs a new type of bioactive glass, especially relates to a kind of bonding and repairing for toothpaste, beauty cosmetics, bone repair and regeneration of bone tissue, scarless wound repair, etc. Methods for the preparation of materials for regenerative medicine of bone and soft tissue. Background technique [0002] Bioactive glass refers to a class of materials used for specific biological or physiological functions, that is, materials that are directly used in the human body or directly related to the human body for biological, medical, and biochemical purposes. The discovery and research of bioactive glass has a history of more than 40 years, and it has been widely used clinically, such as dentistry, maxillofacial science, plastic surgery, and orthopedic repair. It can form a bone bond with bone tissue, promote the growth of bone tissue a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/02A61L27/36
CPCA61L27/025A61L27/10A61L27/12A61L27/36A61L2430/02A61L2430/34
Inventor 胡方
Owner 北京幸福益生高新技术有限公司
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