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A kind of extraction method of ginsenoside

A technology of ginsenoside and extraction method, which is applied in the direction of chemical instruments and methods, glycoside steroids, steroids, etc., can solve problems such as limiting the scope of use, and achieve the effect of wide application field and high purity

Active Publication Date: 2021-06-11
JIANGSU SUNAN PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of total ginsenosides in the ginseng extract produced by the prior art is about 80%, which limits its scope of use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A method for extracting ginsenosides, the method comprising the steps of:

[0023] (1) Wash and mash the ginseng, then add water and stir evenly, adjust the pH to 6, then add pectinase and cellulase to treat for 1~5h to obtain the mixture;

[0024] (2) the mixture that step (1) obtains is passed through the activated carbon column, and the effluent is collected;

[0025] (3) the effluent obtained by step (2) is passed through a non-polar macroporous resin column, and the effluent is collected;

[0026] (4) Process the effluent obtained in step (3) with a nanofiltration membrane to obtain a ginsenoside extract.

[0027] In step (1), the volume ratio of ginseng mass to water is 30g:5L.

[0028] In step (1), the ratio of ginseng mass to pectinase and cellulase activity is 5g: 5000U: 5000U;

[0029] Wherein, the non-polar macroporous resin column is ADS-8.

[0030] Wherein, the nanofiltration membrane is a 0.5 nanometer cellulose membrane.

[0031] In step (1), the tre...

Embodiment 2

[0036] A method for extracting ginsenosides, the method comprising the steps of:

[0037] (1) Wash and mash the ginseng, then add water and stir evenly, adjust the pH to 7, then add pectinase and cellulase to treat for 1~5h to obtain the mixture;

[0038] (2) the mixture that step (1) obtains is passed through the activated carbon column, and the effluent is collected;

[0039] (3) the effluent obtained by step (2) is passed through a non-polar macroporous resin column, and the effluent is collected;

[0040] (4) Process the effluent obtained in step (3) with a nanofiltration membrane to obtain a ginsenoside extract.

[0041] In step (1), the volume ratio of ginseng mass to water is 30g:2L.

[0042] In step (1), the ratio of the mass of ginseng to the activity of pectinase and cellulase is 5g: 3000U: 3000U;

[0043] Wherein, the nonpolar macroporous resin column is BS-65.

[0044] Wherein, the nanofiltration membrane is a 0.5 nanometer cellulose membrane.

[0045] In step...

Embodiment 3

[0050] A method for extracting ginsenosides, the method comprising the steps of:

[0051] (1) Wash and mash the ginseng, then add water and stir evenly, adjust the pH to 7, then add pectinase and cellulase to treat for 1~5h to obtain the mixture;

[0052] (2) the mixture that step (1) obtains is passed through the activated carbon column, and the effluent is collected;

[0053] (3) the effluent obtained by step (2) is passed through a non-polar macroporous resin column, and the effluent is collected;

[0054] (4) Process the effluent obtained in step (3) with a nanofiltration membrane to obtain a ginsenoside extract.

[0055] In step (1), the volume ratio of ginseng mass to water is 100g:4L.

[0056] In step (1), the ratio of the mass of ginseng to the activity of pectinase and cellulase is 2g: 2000U: 2000U;

[0057] Wherein, the non-polar macroporous resin column is ADS-8.

[0058] Wherein, the nanofiltration membrane is a 0.8 nanometer cellulose membrane.

[0059] In st...

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PUM

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Abstract

The invention discloses a method for extracting ginsenosides. The method comprises the following steps: (1) washing and mashing the ginseng, adding water and stirring evenly, adjusting the pH to 6-7, and then adding pectinase and cellulase Treat for 1~5h to obtain the mixture; (2) pass the mixture obtained in step (1) through an activated carbon column, and collect the effluent; (3) pass the effluent obtained in step (2) through a non-polar macroporous resin column, and collect the effluent (4) treating the effluent obtained in step (3) with a nanofiltration membrane to obtain a ginsenoside extract. The purity of the ginsenoside obtained by the invention is greater than 95%, which is higher than that obtained by the traditional method and has wide application fields.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a method for extracting ginsenosides. Background technique [0002] The main active ingredients in ginseng extract are ginsenosides (or called total ginsenosides). It has the main physiological activity of ginseng. In the prior art, the extraction of total ginseng saponins is mainly through extraction, resin adsorption, elution, activated carbon or magnesium oxide decolorization, exchange resin for impurity removal, and drying to obtain finished products. However, the content of total ginsenosides in the ginseng extract produced by the prior art is about 80%, which limits its scope of use. Especially for ginseng extracts used in the production of injections, the impurities in the extract should be as few as possible. Therefore, there is a need for an extraction method capable of extracting a higher purity ginseng extract so that it can be used more wide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J17/00
CPCC07J17/005
Inventor 俞洋徐明陈军王俊
Owner JIANGSU SUNAN PHARMA IND CO LTD