Medicament with functions of resisting oxidization and inhibiting hepatic tissue fibrosis and preparation method thereof

A technology for liver tissue and fibrosis, applied in the field of medicine, can solve the problems of poor therapeutic effect and low antioxidant performance, and achieve the effect of inhibiting liver tissue fibrosis

Inactive Publication Date: 2018-12-11
栾云鹏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing drugs for the treatment of Alzheimer's disease usually have the defects of low antioxidant performance and poor therapeutic effect

Method used

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  • Medicament with functions of resisting oxidization and inhibiting hepatic tissue fibrosis and preparation method thereof
  • Medicament with functions of resisting oxidization and inhibiting hepatic tissue fibrosis and preparation method thereof
  • Medicament with functions of resisting oxidization and inhibiting hepatic tissue fibrosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A drug that has the functions of anti-oxidation and inhibition of liver tissue fibrosis. The drug is made of the following traditional Chinese medicine ingredients: raw ginseng powder: 30%, fennel grassland powder: 15%, dry field grassland powder: 30%, coconut raw powder: 25% %.

[0038] The preparation method comprises the following steps:

[0039] 1) After freeze-drying the stinky ginseng at low temperature, crush it with a mechanical impact mill for 10 minutes, pass through a 100-mesh sieve to obtain the original powder of stinky ginseng, and then use an ultrafine pulverizer to crush it, pass it through a 300-mesh sieve to obtain a drug superfine powder, and pack it into powder, tablet or capsule;

[0040] 2) Take fresh fennel, wash, sort and remove impurities, and dry in the shade naturally, then pulverize with a mechanical impact pulverizer for 10 minutes, and pass through a 100-mesh sieve to obtain the original drug powder, then pulverize with an ultrafine pulver...

Embodiment 2

[0045] A drug that has the functions of anti-oxidation and inhibition of liver tissue fibrosis. The drug is made of the following traditional Chinese medicine ingredients: raw ginseng powder: 80%, fennel prairie powder: 15%, dry field prairie powder: 5%.

[0046] The preparation method comprises the following steps:

[0047] 1) After freeze-drying the stinky ginseng at low temperature, crush it with a mechanical impact mill for 5 minutes, pass through a 120-mesh sieve to obtain the original powder of stinky ginseng, then use an ultrafine pulverizer to crush it, pass it through a 300-mesh sieve to obtain a superfine drug powder, and pack it into powder, tablet or capsule;

[0048] 2) Take fresh fennel, wash, sort and remove impurities, and dry in the shade naturally, then pulverize with a mechanical impact pulverizer for 5 minutes, pass through a 120-mesh sieve to obtain the original drug powder, and then pulverize with an ultrafine pulverizer to pass through a 300-mesh sieve. ...

Embodiment 3

[0052] A drug that has the functions of anti-oxidation and inhibition of liver tissue fibrosis. The drug is made of the following traditional Chinese medicine ingredients: 40%, dry field grassland powder: 20%, and raw coconut powder: 10%.

[0053] The preparation method comprises the following steps:

[0054] 1) After freeze-drying the stinky ginseng at low temperature, crush it with a mechanical impact mill for 10 minutes, pass through a 100-mesh sieve to obtain the original powder of stinky ginseng, and then use an ultrafine pulverizer to crush it, pass it through a 300-mesh sieve to obtain a drug superfine powder, and pack it into powder, tablet or capsule;

[0055] 2) Take fresh fennel, wash, sort and remove impurities, and dry in the shade naturally, then pulverize with a mechanical impact pulverizer for 10 minutes, and pass through a 100-mesh sieve to obtain the original drug powder, then pulverize with an ultrafine pulverizer and pass through a 300-mesh sieve. Mesh sie...

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Abstract

The invention provides a medicament with functions of resisting oxidization and inhibiting hepatic tissue fibrosis and a preparation method thereof. The medicament is prepared from the raw powder or extracts of radix codonopsis foetens, herba rhodobryi gigantei par, herba linderniae ruellioides and coconut. When the medicament is prepared from raw powder, the medicament is prepared from the following components in percentage by mass: 30 to 80 percent of radix codonopsis foetens powder, 15 to 40 percent of herba rhodobryi gigantei par powder, 5 to 30 percent of herba linderniae ruellioides rawpowder and the balance of coconut raw powder. When the medicament is prepared from extracts, the medicament is prepared from the following components: 0.02 to 10g/ml of radix codonopsis foetens extract, 0.02 to 10g/ml of herba rhodobryi gigantei par extract, 0.02 to 10g/ml of herba linderniae ruellioides extract and 0.02 to 10g/ml of coconut extract. By adopting the medicament provided by the invention, the MAO (Monoamine Oxidase) in the liver of an AD (Alzheimer disease) model mouse is reduced, the hepatic tissue fibrosis can be inhibited, the MDA (Methylene Dioxyamphetamine) in the serum ofthe AD model mouse can be reduced, and a certain oxidization effect is achieved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine capable of resisting oxidation and inhibiting liver tissue fibrosis and a preparation method thereof. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. Those with onset before the age of 65 are called Alzheimer's disease; those with onset after the age of 65 are called senile dementia. [0003] Liver fibrosis is a pathophysiological process, which refers to the abnormal proliferation of connective tissue in the liver caused by various pathogenic factors. Any liver injury has a process of liver fibrosis in the process of liver repair and healing. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P25/28A61P1/16A61P39/06
CPCA61K36/10A61K36/34A61K36/80A61K36/889A61K2236/15A61K2236/31A61K2236/331A61K2236/333A61K2236/39A61P1/16A61P25/28A61P39/06A61K2300/00
Inventor 栾云鹏毛德昌曹涌栾云祺李艳梅
Owner 栾云鹏
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