A kind of artificial blood vessel and preparation method thereof

Abstract

The invention provides an artificial blood vessel and a preparation method thereof, which solves the technical problem that the degradation speed of the existing artificial blood vessel does not match the growth and proliferation speed of seeded cells. Connected inner layer support, middle layer support and outer layer support, the inner layer support is a layer of porous fiber circular tubular structure made of polyethylene succinate and anticoagulant; the middle layer support is A layer of porous fibrous tubular structure composed of hydrogel materials, bioceramic materials, and growth factors, the pores of the middle layer support are adhered and filled with the seeded cells; the outer layer support is made of polysuccinic acid A layer of porous fiber circular tubular structure composed of butanediol ester; at the same time, it discloses a preparation method of artificial blood vessels, which can be widely used in the field of implantable medical devices.

Description

technical field [0001] The invention relates to the field of implantable medical devices, in particular to an artificial blood vessel and a preparation method thereof. Background technique [0002] At present, cardiovascular disease and peripheral arterial disease are the main causes of human death in the world. Approximately 600,000 vascular grafts are performed each year, but nearly one-third of patients cannot use autologous blood vessels because of vascular aging, vascular disease, injury or previous surgical use. Currently commonly used stent materials mainly include non-degradable vascular stent materials and degradable vascular stents. Non-degradable vascular stents mainly include stainless steel, nickel-titanium alloy and other materials. These metal materials are not degradable in the human body and need to be kept in the body permanently, which increases the risk of restenosis. In this case, the use of degradable artificial blood vessels has become a good choice....

AI Technical Summary

Problems solved by technology

However, the seeded cells of the existing artificial blood vessels proliferate and form a film on the inner wall of the artificial blood vessel inner layer stent. With the continuous degradation of the inner layer stent, the middle layer stent, and the outer layer stent, the cells gradually grow and proliferate to form the middle layer and the outer layer. Among them, the main problem is that the degradation rate of the vascular stent does not match the growth and proliferation rate of the inoculated cells, that is, the growth of the inoculated cells in the inner layer of the artificial vascular stent is slow, while the degradation rate of the vascular stent is too slow to hinder cell growth or the degradation rate is too fast to prevent the growth of cells. The problem with meeting the needs of growing blood vessels

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