Medicine for preventing and treating ischemic heart disease or ischemic encephalopathy or thrombosis and application

A technology for ischemic heart disease and hemorrhage, applied in the direction of medical preparations containing active ingredients, blood diseases, drug combinations, etc., to achieve the effects of inhibiting lipid peroxidation, increasing ROS) levels, and preventing the risk of death

Inactive Publication Date: 2018-12-21
BMK BIOMEDICAL TECH GUANGZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the application of indole-3-carbinol in the...

Method used

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  • Medicine for preventing and treating ischemic heart disease or ischemic encephalopathy or thrombosis and application
  • Medicine for preventing and treating ischemic heart disease or ischemic encephalopathy or thrombosis and application
  • Medicine for preventing and treating ischemic heart disease or ischemic encephalopathy or thrombosis and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] An application of indole-3-carbinol and its derivatives having the following structural formula (I) in the preparation of drugs for preventing and treating ischemic heart disease or ischemic encephalopathy or thrombosis,

[0043]

[0044]Wherein, R1, R2, R4, R5, R6, R7 are respectively in H, phenyl, benzoyl, Cl-C10 acyl, halogen substituent, nitro, Cl-C10 alkyl, Cl-C10 alkoxyl A sort of.

Embodiment 2

[0046] On the basis of the example. In the structural formula (I), R1 is one of phenyl, benzoyl, and Cl-C10 acyl, and R2, R4, R5, R6, and R7 are all hydrogen.

Embodiment 3

[0048] On the basis of embodiment 1. In the structural formula (I), R5 is one of hydroxyl, methoxy, halogen substituent, nitro, Cl-C10 alkyl, Cl-C10 acyl, R1, R2, R4, R6, R7 are all hydrogen .

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PUM

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Abstract

The invention discloses a medicine for preventing and treating ischemic heart disease or ischemic encephalopathy or thrombosis and application. The medicine comprises indole-3-methanol and a derivative thereof, or diindolylmethane and a derivative thereof. The medicine further comprises a carrier acceptable on pharmacy, wherein the carrier comprises a beverage or a food. The medicine can be used for treating and preventing coronary atherosclerotic heart disease, ischemic heart disease caused by luminal stenosis or luminal occlusion due to inflammation thrombosis, embolism or damage, thrombosis, cerebral infarction, ischemic cerebral apoplexy, cerebral thrombosis, cerebral embolism, lacunar ischemic cerebral apoplexy, frequent ischemic cerebral apoplexy and transient ischemic attack.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a medicine for preventing and treating ischemic heart disease, ischemic encephalopathy or thrombosis and its application. Background technique [0002] In recent years, with the development of society and economy, the change of eating habits and environment, the aggravation of the rhythm of life and the acceleration of population aging process, the morbidity and mortality of cardiovascular and cerebrovascular diseases, coronary heart diseases and cerebral apoplexy all over the world are showing a trend. rising trend year by year. According to the "China Cardiovascular Disease Report 2016", it is estimated that the number of patients with coronary atherosclerotic heart disease has reached 11 million. Ischemic heart disease, also known as coronary heart disease, includes atherosclerotic lesions in the coronary arteries that cause stenosis or blockage of the vessel lumen, resultin...

Claims

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Application Information

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IPC IPC(8): A61K31/404A61P9/10A61P7/02
CPCA61K31/404A61P7/02A61P9/10
Inventor 钟诗龙马红坤张姗姗汤雅男
Owner BMK BIOMEDICAL TECH GUANGZHOU CO LTD
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