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Measurement method and detection device of body fluid drug concentration based on surface enhanced Raman spectrum

A surface-enhanced Raman and Raman spectroscopy detection technology, applied in the physical field, can solve the problems of cumbersome sample processing, expensive operation requirements, and easy-to-interference prices, and achieve the effects of precise disease treatment, obvious technical effects, and environmental protection

Inactive Publication Date: 2018-12-21
上海银波生物科技有限公司
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Problems solved by technology

[0007] The object of the present invention is to provide a measurement method and a detection device for a body fluid drug concentration based on surface-enhanced Raman spectroscopy. Technical problems such as cumbersome sample handling, easy interference, high price and high operation requirements

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  • Measurement method and detection device of body fluid drug concentration based on surface enhanced Raman spectrum

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Embodiment 1

[0029] Such as figure 1 As shown, the present invention provides a device for measuring the concentration of body fluid drugs based on surface-enhanced Raman spectroscopy, including: a stage 7, a Raman spectrum excitation light source 9 and a spectrometer 1, wherein the Raman spectrum excitation light source 9 is located on the stage 7 below; the spectrometer 1 is located above the stage 7;

[0030] A beam shaping system 8 is arranged in the light path where the Raman spectrum excitation light source 9 emits laser light to irradiate the sample.

[0031] In the direction of collecting Raman scattered light of the spectrometer 1, a scattered light concentrator 5, an optical filter 4, a coupling mirror 3 and an optical fiber 2 are sequentially arranged, and the optical fiber 2 connects the spectrometer 1 and the optical fiber 2. The coupling mirror 3 described above.

[0032] The detection process of the present invention is: comparing the data of 20 patients with epilepsy. Fi...

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Abstract

The invention provides a measurement method of body fluid drug concentration based on a surface enhanced Raman spectrum. The method comprises the following steps: obtaining body fluid containing a drug from a patient, obtaining a purified sample by a conventional pretreatment method, placing a certain amount of the sample in a container containing a nano-gold or nano-silver solution with standardconcentration, uniformly mixing the sample with the nano-gold or nano-silver solution by shaking or swinging or rotating the container, then forming a uniform thin layer with a certain thickness at the bottom of the container through centrifugal concentration, directly performing transmission Raman spectrum detection on the uniform thin layer formed at the bottom of the container to obtain a surface enhanced Raman spectrogram of drug molecules, and obtaining a drug content in the blood via model calculation. The invention further provides a device for implementing the above method. By means ofthe detection and analysis of the surface enhanced transmission Raman spectrum, the drug concentration measurement is performed, and the measured minimum concentration limit reaches a ppb level.

Description

technical field [0001] The invention relates to the field of physics, in particular to light detection technology, in particular to a measurement method and detection device for body fluid drug concentration based on surface-enhanced Raman spectroscopy. Background technique [0002] We know that the amount of food eaten by different people can vary significantly, and the amount of food eaten is not always proportional to body weight and body surface area. The same is true for medication, which is also administered according to the standard dose. Some patients will have insufficient dosage due to excessive metabolism, while some patients will actually overdose and have toxic side effects due to slow metabolism. If the drug concentration in the blood fluctuates, it will not only affect the curative effect, but also induce bacterial drug resistance. [0003] Therefore, it is very necessary to monitor the blood drug concentration, especially for drugs with narrow safety range a...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 倪勤朱宝强苏江文龚辉
Owner 上海银波生物科技有限公司
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