Application of GABAB receptor antagonist in aspect of blocking TREK-1 channel

A technology of receptor antagonists and channels, applied in the application field of GABAB receptor antagonists in blocking TREK-1 channels, can solve the problems of inability to achieve antidepressant treatment, increase the complexity of the onset of depression, the complexity of pathogenesis, etc. question
CN109125331AInactive Publication Date: 2019-01-04THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
Publication Date
2019-01-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to an application of a GABAB receptor antagonist in an aspect of blocking a TREK-1 channel. It is indicated from research in an embodiment of the application that the GABAB receptor antagonist acts on the TREK-1 channel and has the anti-depression effect, it has important theoretical significance and anapplication value to reveal a pathogenesis of depression and guide clinical compatibility of drugs. So, the GABAB receptor antagonist has good application prospect in aspects of preparing an antidepressant drug and a biliary tract obstruction drug, and preparing drugs for treating TREK-1 channel related diseases.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, in particular to GABA B Use of receptor antagonists in blocking TREK-1 channels. Background technique

[0002] Depression, also known as depressive disorder, is characterized by low emotion, slow thinking, and decreased speech and movement. Depression has seriously plagued the life and work of patients, and brought a heavy burden to families and society. Studies have shown that about 15% of patients with depression die by suicide, accounting for two-thirds of the total suicide population. According to the World Health Organization, there are 350 million patients with depression in the world, and nearly 100 million in my country. Depression has become the fourth largest disease in the world. According to WHO's global medical burden of disease, depression will become the second largest psychosomatic disorder in the world in the next ten years. So far, the etiology of depression is not clear,...

Claims

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