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Preparation method of fried gardenia formula granules

A technology of formula granules and stir-fried gardenia, applied in pharmaceutical formulas, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Inconsistency and other problems, to achieve the effect of improving product yield and production efficiency, ensuring product quality, and solving static electricity and agglomeration phenomenon

Inactive Publication Date: 2019-01-11
KANGMEI PHARMA
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Problems solved by technology

[0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are processed from Chinese herbal decoction pieces through various processes, and are used for clinical prescription of traditional Chinese medicine. Controllable, easy to store, and easy to carry; at present, Chinese medicine formula granules are in a pilot state in China, and the product process and quality standards are not uniform; at present, traditional Chinese medicine formula granules are basically extracted with water, or extracted with water after extracting volatile oil, and there are currently some varieties Due to the internal reasons of the product itself, there are certain technical difficulties in the production process and improper control, which affects the internal quality of the final product.
Static electricity is easy to be generated during the mixing process of fried gardenia spray dry powder, causing the spray dry powder to form agglomerates, making it difficult to mix evenly

Method used

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  • Preparation method of fried gardenia formula granules

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preparation example Construction

[0020] A preparation method of fried gardenia formula granules, characterized in that it comprises:

[0021] Extraction and concentration steps: take fried gardenia decoction pieces, add water to extract and decoct, and obtain the extract after filtration; concentrate the extract under reduced pressure to obtain a concentrate; the concentration temperature is 75-85°C, and the relative density of the concentrate is 1.00-1.02 ;

[0022] Spray-drying step: heating the concentrated solution, stirring evenly, and then spray-drying to obtain fried gardenia spray-dried powder;

[0023] Dry granulation step: first add silicon dioxide to the spray-dried powder of fried gardenia, the amount of silicon dioxide added is 0.5% of the weight of the spray-dried powder of fried gardenia, and after mixing evenly, dry granulation is carried out to obtain fried gardenia Subrecipe particles.

[0024] As a preferred embodiment, in the extraction and concentration step, the amount of water added i...

Embodiment 1

[0035] A preparation method of fried gardenia formula granules, comprising:

[0036] Extraction and concentration steps: Take 100kg of fried gardenia decoction pieces, add water 9 times the weight of the fried gardenia decoction pieces, control the extraction temperature at 98°C, extract and decoct for 1 hour, filter the extract; control the concentration temperature at 80°C, and concentrate under reduced pressure to relative Concentrate with a density of 1.01;

[0037] Spray drying step: heat the concentrated solution to 80°C, stir well, and control the spray drying parameters: air inlet temperature 175°C, temperature inside the tower 92°C, blast frequency 40Hz, induced wind frequency 45Hz, atomization frequency 40Hz, material delivery temperature 50 ℃, the concentrated solution was kept at a temperature of 80 ℃, and spray-dried to obtain 20 kg of fried gardenia spray-dried powder, with a yield of 92%; (%)=actual dry powder weight (g) / theoretical dry powder weight×100%);

...

Embodiment 2

[0040] A preparation method of fried gardenia formula granules, comprising:

[0041] Extraction and concentration steps: Take 100kg of fried gardenia decoction pieces, add water 9 times the weight of the fried gardenia decoction pieces, control the extraction temperature at 100°C, extract and decoct for 1 hour, filter the extract; control the concentration temperature at 85°C, and concentrate under reduced pressure to relative Concentrate with a density of 1.02;

[0042] Spray drying step: heat the concentrated solution to 80°C, stir well, and control the spray drying parameters: air inlet temperature 180°C, temperature inside the tower 95°C, blast frequency 45Hz, induced wind frequency 50Hz, atomization frequency 45Hz, feeding temperature 60 ℃, concentrated solution holding temperature 85 ℃, carry out spray drying to obtain 19.5kg of fried gardenia spray-dried powder, yield is 91%; (note: theoretical spray-dried powder weight=concentrated solution weight×concentrated solution...

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Abstract

The invention discloses a preparation method of fried gardenia formula granules, which comprises the following steps of: extracting and concentrating: taking the fried gardenia slices, extracting anddecocting with water, and filtering to obtain extractive solution; concentrating the extract under reduced pressure to obtain a concentrated solution, wherein the concentration temperature is 75-85 DEG C, and the relative density of concentrated solution is 1.00-1.02; spray drying step: heating the concentrated solution, stirring evenly, and then spray drying to obtain fried gardenia spray-dryingpowder; dry granulating step: firstly, adding silicon dioxide into the spray-dried powder of fried gardenia, uniformly mixing, and then dry granulating to obtain fried gardenia formula granules. By adding 0.5% of silicon dioxide and maltodextrin to the dry granulation step and optimizing the parameters of each step, the static electricity and agglomeration phenomenon can be effectively solved, theproduct yield and production efficiency can be improved, and the product quality can be guaranteed.

Description

technical field [0001] The invention relates to a preparation method of traditional Chinese medicine formula granules, in particular to a preparation method of fried gardenia formula granules. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are processed from Chinese herbal decoction pieces through various processes, and are used for clinical prescription of traditional Chinese medicine. Controllable, easy to store, and easy to carry; at present, Chinese medicine formula granules are in a pilot state in China, and the product process and quality standards are not uniform; at present, traditional Chinese medicine formula granules are basically extracted with water, or extracted with water after extracting volatile oil, and there are currently some varieties Due to the internal reasons of the product itself, there are certain technical difficulties in the production process and impro...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/16A61K47/04A61K47/36
CPCA61K9/1611A61K9/1652A61K36/744A61K2236/331A61K2236/51A61K2236/53
Inventor 许冬瑾林钟峰林哲行许沛锭王文涛曾国荣贺秀容
Owner KANGMEI PHARMA
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