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Paricalcitol soft capsule

A technology for paricalcitol and soft capsules, applied in the field of pharmaceutical preparations, can solve problems such as the problem of stability of paricalcitol soft capsules that are not well solved, and achieve the effect of improving stability

Inactive Publication Date: 2019-01-22
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The above prior art does not well solve the stability problem of Paricalcitol Soft Capsules

Method used

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  • Paricalcitol soft capsule
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Embodiment Construction

[0021] The present invention will be further explained below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and not to limit the scope of the present invention. The experimental methods that do not indicate specific conditions in the following examples usually follow the conventional conditions or the conditions recommended by the manufacturer. Unless otherwise stated, all percentages, ratios, ratios or parts are by weight.

[0022] Unless otherwise defined, all professional and scientific terms used in the text have the same meaning as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to the content described can be applied to the method of the present invention. The preferred implementation methods and materials described in the article are for demonstration purposes only.

[0023] Test 1: The effect of solvent on the stability of P...

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Abstract

The invention relates to a paricalcitol soft capsule, and belongs to the field of a medicine preparation. The invention provides a paricalcitol soft capsule, which comprises contents of paricalcitol,antioxidants and a solvent, wherein the solvent is prepared from water and propanediol; and the antioxidants include water-soluble antioxidants and oil-soluble antioxidants. The recipe of the paricalcitol soft capsule is optimized and screened; and the recipe optimization mainly comprises two aspects including the solvent and the antioxidants, so that the stability of the paricalcitol soft capsuleis improved. Through experiment study, the result that the stability of the paricalcitol soft capsule can be effectively improved by using propanediol and water as the solvent and simultaneously using the two kinds of antioxidants including water-soluble antioxidants and oil-soluble antioxidants is discovered.

Description

Technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a soft capsule of Paricalcitol. Background technique [0002] Paricalcitol, chemical name (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy- 5,6-dimethylhept-3-en-2-y1]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol , The structural formula is as follows: [0003] [0004] Paricalcitol is an active vitamin D analogue. It is a synthetic vitamin D analogue with biological activity. It can modify the side chain (D2) and A ring (19-nor) of calcitriol, which is effective Suppress the level of parathyroid hormone (PTH). Although the structure of paricalcitol is similar to calcitriol, compared with calcitriol, it can inhibit parathyroid hormone more quickly and lastingly, and has little effect on calcium, phosphorus and calcium phosphorus deposition, so it is less Persistent hypercalcemia occurs, and the drug is better than calcitriol in ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/592A61K47/10A61K47/04A61K47/20A61K47/22A61K47/24A61P5/20A61P19/10
CPCA61K9/485A61K9/4858A61K31/592A61P5/20A61P19/10
Inventor 陈阳生王明刚孙桂玉刘晓霞杜昌余刘振玉王清亭刘昭嵘
Owner CP PHARMA QINGDAO CO LTD
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