Supercharge Your Innovation With Domain-Expert AI Agents!

Lomefloxacin hydrochloride ear drop

A technology of lomefloxacin hydrochloride and ear drops, which is applied in the direction of emulsion delivery, medical preparations of non-active ingredients, organic active ingredients, etc., can solve the problems of low viscosity, poor bioavailability, and loss of liquid medicine, and achieve Effect of reducing irritation, reducing discomfort, and good therapeutic effect

Inactive Publication Date: 2019-01-25
禹州市中医院
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the lomefloxacin hydrochloride ear drops used uses ethanol as a cosolvent, which has a strong irritating effect on the auricular mucous membrane. Many patients reported that pain and unbearable symptoms occurred after dripping lomefloxacin hydrochloride, and the viscosity of the liquid Low, severe loss, poor bioavailability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lomefloxacin hydrochloride ear drop

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A lomefloxacin hydrochloride ear drop, each 1000mL ear drop contains: 2.5-3.5g of lomefloxacin hydrochloride, 40-80g of glycerin, 12-18g of hydrogenated castor oil, 15-25g of polyethylene glycol, and ethylenediamine Disodium tetraacetate 0.6-1.4g; hydrogenated castor oil is preferably peg40 hydrogenated castor oil, polyethylene glycol is preferably polyethylene glycol 400.

[0013] The preparation method of the above-mentioned lomefloxacin hydrochloride ear drops comprises the following steps: adding the formula amount of lomefloxacin hydrochloride into an appropriate amount of water, heating to 40-50°C, and ultrasonically dissolving; then adding the formula amount of glycerin, hydrogenated castor Sesame oil, polyethylene glycol and edetate disodium, stir evenly, add water to 1000mL, filter through a sterile filter membrane to obtain lomefloxacin hydrochloride ear drops.

Embodiment 2

[0015] A lomefloxacin hydrochloride ear drop, each 1000mL ear drop contains: 3g of lomefloxacin hydrochloride, 60g of glycerin, 15g of peg40 hydrogenated castor oil, 20g of polyethylene glycol 400, and 1g of disodium edetate.

[0016] The preparation method of the above-mentioned lomefloxacin hydrochloride ear drops comprises the following steps: adding the lomefloxacin hydrochloride of the formulation amount to an appropriate amount of water, heating to 45°C, and ultrasonically dissolving; then adding the formulation amount of glycerin, hydrogenated castor oil, Polyethylene glycol and edetate disodium, stir well, add water to 1000mL, filter through a 0.45um sterile filter membrane to obtain lomefloxacin hydrochloride ear drops.

Embodiment 3

[0018] A lomefloxacin hydrochloride ear drop, each 1000mL ear drop contains: 3.5g of lomefloxacin hydrochloride, 70g of glycerin, 15g of peg40 hydrogenated castor oil, 23g of polyethylene glycol 400, 0.8g of disodium edetate .

[0019] The preparation method of the above-mentioned lomefloxacin hydrochloride ear drops comprises the following steps: adding the lomefloxacin hydrochloride of the formulation amount to an appropriate amount of water, heating to 48°C, and ultrasonically dissolving; then adding the formulation amount of glycerin, hydrogenated castor oil, Polyethylene glycol and edetate disodium, stir well, add water to 1000mL, filter through a 0.45um sterile filter membrane to obtain lomefloxacin hydrochloride ear drops.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A lomefloxacin hydrochloride ear drop contains lomefloxacin hydrochloride 2.5-3.5 g, glycerol 40-80g, hydrogenate castor oil 12-18g, polyethylene glycol 15-25g of disodium ethylenediamine tetraacetate0.6-1.4g per 1000mL ear drop. The lomefloxacin hydrochloride ear drops provided by the invention Using hydrogenated castor oil and polyethylene glycol as cosolvent, Lomefloxacin hydrochloride ear drops can be self-aggregated to form micellar solution by glycerol as penetration enhancer and EDTA disodium as buffer, which not only reduces irritation of ear drops and discomfort of patients, but alsoprolongs residence time of ear drops, improves bioavailability and achieves better therapeutic effect.

Description

technical field [0001] The invention relates to an ear drop, in particular to a lomefloxacin hydrochloride ear drop. Background technique [0002] Chronic suppurative otitis media is a common multiple-occurring disease in otolaryngology. According to the cases and clinical manifestations, the disease can be divided into simple type, bone ulcer type and cholesteatoma type, among which the simple type is the most common. Conservative treatment to control infection and unobstructed drainage. The applicant once used oral cefradine capsules and lomefloxacin hydrochloride ear drops in combination, and achieved good curative effect. However, the lomefloxacin hydrochloride ear drops used uses ethanol as a cosolvent, which has a strong irritating effect on the auricular mucous membrane. Many patients reported that pain and unbearable symptoms occurred after dripping lomefloxacin hydrochloride, and the viscosity of the liquid Low, serious loss, poor bioavailability. Contents of th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/44A61K47/10A61K47/18A61K31/496A61P27/16
CPCA61K9/0046A61K9/1075A61K31/496A61K47/10A61K47/183A61K47/44A61P27/16
Inventor 余亚明秦怀生郭风
Owner 禹州市中医院
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com