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Preparation method of CMCs hydrogel, CMCs hydrogel prepared by preparation method and application of CMCs hydrogel

A hydrogel and water washing technology, applied in applications, household appliances, inks, etc., can solve the problems of limiting the application of carboxymethyl chitosan hydrogel, complicated preparation process, non-biodegradability, etc., and achieve good biocompatibility good biocompatibility, good rheology and stiffness

Inactive Publication Date: 2019-01-29
HUZHOU SIMAN BIOLOGICAL MATERIAL CO LTD +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the common method for preparing carboxymethyl chitosan (CMCs) hydrogel is chemical cross-linking method, which has problems such as complicated preparation process and various raw materials. Most cross-linking agents (glutaraldehyde, epichlorohydrin, etc.) tend to be cytotoxic and non-biodegradable, which greatly limits the application of carboxymethyl chitosan hydrogels

Method used

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  • Preparation method of CMCs hydrogel, CMCs hydrogel prepared by preparation method and application of CMCs hydrogel

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preparation example Construction

[0017] The invention relates to a novel method for preparing a CMCs-based hydrogel, the method comprising: freezing a CMCs-based solution to obtain a CMCs-based solution solid; and mixing the CMCs-based solution solid with an acidic solution to prepare a CMCs-based water gel Gel, wherein the CMCs-based solution is a CMCs solution or a CMCs-CNT solution.

[0018] The chitosan solution is frozen before gelation, and the solid chitosan solution thus obtained quickly forms a gel phase when encountering an acidic solution. This pre-freezing method can avoid the influence of rapid gelation on hydrogel setting and achieve uniform gelation of CMCs.

[0019] In the present invention, in consideration of quicker and more uniform solidification, it is preferable to freeze the CMCs-based solution after casting it into a mold such as a glass dish.

[0020] In the present invention, considering a better cross-linking effect, it is preferred that the mixing time of the CMCs-based solution a...

Embodiment 1

[0028] Carboxymethyl chitosan (purchased from Xi'an Dafengshou Biotechnology Co., Ltd., trade name: "carboxymethyl chitosan", carboxymethyl degree is 90%, weight average molecular weight is 3 × 10 5 ) was dissolved in deionized water, stirred continuously at room temperature for 30 minutes to completely dissolve, and the obtained concentration was 30 mg / ml carboxymethyl chitosan (CMCs) solution; then, the prepared CMCs solution was cast into a glass dish , frozen at -20°C for 1 hour to prepare a solid CMCs solution; then, mix the solid CMCs solution with 1M HCl solution at a weight ratio of 1:2 for 30 minutes to prepare a CMCs hydrogel; finally, wash with water to prepare The resulting CMCs hydrogels were removed from acid residues.

Embodiment 2

[0030] The CMCs hydrogel was prepared by the same method as in Example 1, except that the HCl solution was changed to the HAC solution.

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Abstract

The invention provides a preparation method of a carboxymethyl chitosan (CMCs) hydrogel, a carboxymethyl chitosan hydrogel prepared by the preparation method and application of the carboxymethyl chitosan hydrogel. The preparation method of the present invention comprises: freezing a carboxymethyl chitosan solution; and crosslinking the frozen carboxymethyl chitosan solution by an acidic solution to obtain the carboxymethyl chitosan hydrogel. The preparation method of the invention has a simple process, does not require any chemical reaction in the middle, and can obtain the carboxymethyl chitosan hydrogel, which is non-toxic, has good biocompatibility and mechanical adaptability, in a simple manner.

Description

technical field [0001] The invention relates to a preparation method of carboxymethyl chitosan (CMCs) hydrogel, a CMCs hydrogel prepared therefrom and an application of the CMCs hydrogel. Background technique [0002] Electronic skin is one of the hottest fields of cutting-edge technology nowadays. Simply put, electronic skin is a flexible electronic device made of thin, bendable, stretchable, and elastic materials. Electronic skin can simulate the sensory function and mechanical properties of human skin, and has good application prospects in artificial intelligence, wearable devices, biomedicine and other fields. [0003] Hydrogel is a colloidal substance formed by cross-linking water-soluble molecules, which can swell in water and retain a large amount of water without dissolving. Because of this characteristic of hydrogels, hydrogels can respond to changes in the external environment, such as temperature, pH, electric field and other conditions, which are especially sui...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08K3/04C09D11/14B33Y70/00
CPCB33Y70/00C08J3/075C08J2305/08C08K3/041C08K2201/011C09D11/14
Inventor 邢孟秋吴军叶海雁刘抗邱佩琪
Owner HUZHOU SIMAN BIOLOGICAL MATERIAL CO LTD
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