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Applications of aurantio-obtusin in preparation of inflammation eliminating and photoaging prevention products

A technology of orange cassiatin and photoaging, which is applied in the field of orange cassiatin, can solve the problems that there are no reports of orange cassiatin anti-inflammatory and photoaging prevention, and achieve good application prospects

Active Publication Date: 2019-02-01
上海艾济生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the effect of orange cassiatin on anti-inflammation and prevention of photoaging

Method used

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  • Applications of aurantio-obtusin in preparation of inflammation eliminating and photoaging prevention products
  • Applications of aurantio-obtusin in preparation of inflammation eliminating and photoaging prevention products
  • Applications of aurantio-obtusin in preparation of inflammation eliminating and photoaging prevention products

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Embodiment Construction

[0023] The technical solution of this patent will be further described in detail below in conjunction with specific embodiments.

[0024] RAW264.7 mouse macrophages induced by lipopolysaccharide (LPS) are a common model for studying inflammatory responses. Under the stimulation of lipopolysaccharide LPS, macrophages can promote the secretion of inflammatory factors such as nitric oxide (NO) and interleukin-6 (interleukin 6). In the present invention, LPS induces RAW264.7 cells to release NO and IL-6 as targets, and investigates the anti-inflammatory effect of arurinine cassiatin.

[0025] Skin aging includes natural aging and photoaging. In addition to causing changes in skin color, texture, elasticity, thickness, etc., photoaging may even cause various benign or malignant tumors to appear on the skin, which has a serious impact. Skin photoaging is closely related to UV irradiation. UVB mainly acts on keratinocytes in the epidermis of the skin, causing the above changes in sk...

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Abstract

The invention discloses applications of aurantio-obtusin in preparation of inflammation eliminating and photoaging prevention products. According to the present invention, LPS induced release of NO and IL-6 from RAW264.7 cells is used as the target, such that the results verify that the aurantio-obtusin has good inflammation eliminating effect, and the results prove that the aurantio-obtusin has good application prospect in preparation of inflammation eliminating products; and UVB induced secretion of IL-6 and IL-1[alpha] from HaB cells is used as the target, such that the results verify thatthe aurantio-obtusin has good photoaging prevention effect, and the results prove that the aurantio-obtusin has good application prospect in preparation of photoaging prevention products.

Description

technical field [0001] The invention relates to the field of orange-yellow cassiatin, in particular to the application of orange-yellow cassiatin in the preparation of anti-inflammatory and photoaging prevention products. Background technique [0002] Semen Cassiae was first recorded in "Shen Nong's Materia Medica", and it is the dried mature seed of Cassia obtusifolia L. or Cassia tora L. of leguminous plants. For clearing heat and improving eyesight, moistening intestines and laxative. [0003] Modern pharmacological research shows that cassia seed has the effects of lowering blood fat, enhancing immunity, anti-oxidation, protecting liver, promoting gallbladder, relieving asthma, inhibiting bacteria, and resisting atherosclerosis. Orange cassiatin is the exclusive ingredient in cassia seed. Its properties are yellow needle crystal anthraquinone compounds. This compound has various biological activities such as lowering blood sugar, lowering blood fat, anti-estrogen and in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P29/00A61P39/06
CPCA61K31/122A61P29/00A61P39/06
Inventor 周鲁先李宁王惠琇
Owner 上海艾济生物科技有限公司