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Stiripentol tablet composition

A technology for stiripentol tablets and amyl alcohol tablets, which is applied in the field of pharmaceutical preparations, can solve the problems of tablet bulging, limited amount of added auxiliary materials, increase in substances, etc., and achieves the effects of stable performance and improved dissolution rate.

Inactive Publication Date: 2019-02-12
WEIHAI YUNRUI INFORMATION TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because stiripentol is insoluble in water, and the bulk drug is easy to absorb moisture, it brings certain difficulties to the preparation of tablets
On the one hand, due to the large size, the amount of added excipients is limited; on the other hand, after the solubility reaches the standard, the tablet is very easy to absorb moisture during storage, causing the tablet to burst, or the contents of the capsule to form a ball, and Significantly increased related substances

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1. 250-500g of stiripentol, 1-1.8g of sodium lauryl sulfate, 0.8-1.5g of Tween 80, 1.6-3.5g of calcium sulfate, 40-70g of lactose, 26-50g of microcrystalline cellulose , cornstarch 15-22g, magnesium stearate 1.0-1.8g, prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 2

[0020] Embodiment 2. 250-500g of stiripentol, 1-1.8g of sodium lauryl sulfate, 0.8-1.5g of Tween 80, 1.6-3.5g of calcium sulfate, 40-70g of lactose, 26-50g of microcrystalline cellulose , cornstarch 15-22g, magnesium stearate 1.0-1.8g, prepare 1000 tablets according to the preparation method described in the technical scheme.

Embodiment 3

[0021] Embodiment 3. 250g of stiripentol, 1.3g of sodium lauryl sulfate, 1.0g of Tween 80, 1.8g of calcium sulfate, 55g of lactose, 30g of microcrystalline cellulose, 18g of cornstarch, 1.2g of magnesium stearate, Prepare 1000 tablets according to the preparation method described in the technical scheme.

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PUM

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Abstract

The invention relates to an anti-epileptic composition, and belongs to the technical field of medicinal preparation.The stiripentol tablet composition per thousand tablets is prepared from 250 to 500g of stiripentol, 1 to 1.8 g of sodium dodecyl sulfate, 0.8 to 1.5 g of tween-80, 1.6 to 3.5 g of calcium sulphate, 40 to 70 g of lactose, 26 to 50 g of microcrystalline cellulose, 15 to 22 g of cornstarch and 1.0 to 1.8 g of magnesium stearate. Through the reasonable prescription dispensing, the invention provides the stiripentol tablet composition with stable performance; high-quality medicineis provided for the clinics.

Description

technical field [0001] The invention relates to an antiepileptic composition and belongs to the technical field of pharmaceutical preparations. Background technique [0002] Dravet syndrome, also known as severe myoclonic epilepsy in infants (severe myoclonic epilepsy ininfarlcy, SMEI), is a clinically rare and intractable epilepsy syndrome. Dravet syndrome can lead to severe epileptic encephalopathy. It is characterized by early onset age, complex seizure patterns, high seizure frequency, severe intellectual impairment, low efficacy of drug treatment, poor prognosis, and high mortality. It is also a representative of intractable epilepsy. The treatment methods can be surgical treatment or neuromodulation. If the cause is unknown, drug treatment can be selected. Epilepsy in children has a great impact on the child's development and intelligence. [0003] Current treatment options for Dravet syndrome are limited and patients require a continuum of care that can have a serio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/36A61K47/26A61K47/20A61K47/02A61P25/08
CPCA61K9/2018A61K9/2009A61K9/2013A61K9/2095A61K31/36A61P25/08
Inventor 不公告发明人
Owner WEIHAI YUNRUI INFORMATION TECH CO LTD