Ginkgo leaf freeze-dried powder injection for injection and preparation method thereof

Abstract

The invention discloses a ginkgo leaf freeze-dried powder injection for injection. The injection comprises the steps of taking dried ginkgo leaves, pulverizing into an extract for use, adding 60% ethanol with 5 times of a volume of slags into the slags, conducting inverse flow, extracting twice, combining a extract, filtering, concentrating to a solution with a relative density of 1.20-1.30 at 70DEG C, and adjusting a supernatant to pH 4; eluting the supernatant to a colorless state, discarding an eluate, using the eluate to recover the ethanol, and adding water saturated ethyl acetate for later use; adjusting the pH to 8 with a water layer, extracting twice with water-saturated n-butanol, adjusting the pH to 10, adjusting the pH of the supernatant to 5, continuing to concentrate, addingthe ethanol to make ethanol up to 10%, adding 0.4% activated carbon, boiling, filtering, and obtaining an extract of the ginkgo leaves; taking 60 parts, by weight, of the above ginkgo leaf extract, adding 60 parts, by weight, of a freeze-dried shaping preparation, adjusting the pH, filtering, freeze-drying, and obtaining the ginkgo leaf freeze-dried powder injection.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a ginkgo leaf freeze-dried powder injection for injection and a preparation method thereof Background technique [0002] Clinical and pharmacological studies have found that Ginkgo biloba extract can enhance heart function, improve microcirculation, reduce blood viscosity, antagonize platelet activating factor (PAF), remove free radicals in the body and significantly dissolve fibrinogen, and inhibit blood flow after reperfusion. damage, enhance the tolerance of cardiac cells to ischemia, etc. In foreign countries, especially in Germany and France, a certain amount of Ginkgo biloba extract has been used clinically and its effect has been proved. At present, it has developed to dozens of countries such as Europe, Asia, and the United States. At present, many medicines and health foods that can effectively treat and prevent cardiovascular a...

AI Technical Summary

Problems solved by technology

The main problems in the existing technology: the total amount of active ingredients extracted is not high, the process route is not reasonable enough, or the industrialization conditions are not available, etc.