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Production method for rumen-bypassing preparation, and granules obtained by means of production method for rumen-bypassing preparation

A rumen-passing and preparation technology, which is used in food ingredients as coating agents, animal feed molding or processing, food science, etc., can solve difficult problems and achieve high stability

Inactive Publication Date: 2019-03-01
生物科学株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the granules obtained by this method have a certain pore volume, and the active ingredient can be released rapidly or continuously, so it is difficult to solve the problem of avoiding the release and decomposition of the active ingredient in the rumen of ruminants

Method used

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  • Production method for rumen-bypassing preparation, and granules obtained by means of production method for rumen-bypassing preparation
  • Production method for rumen-bypassing preparation, and granules obtained by means of production method for rumen-bypassing preparation
  • Production method for rumen-bypassing preparation, and granules obtained by means of production method for rumen-bypassing preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Example 1: Rumen Passed Vitamin D 3 Preparation of formulations and analysis of the resulting formulations

Embodiment 1-1

[0071] Example 1-1: Rumen Passed Vitamin D 3 Preparation of formulations and determination of their particle size distribution

[0072] In this example, a vitamin D3 formulation was prepared and its particle size distribution is shown.

[0073] 100 kg of hydrogenated palm oil was melted at 72°C. To this melt was added 6.25 g of vitamin D dissolved in soybean oil 3 , stir until uniform. The obtained solution was sent to a vibrating granulator having a die hole diameter of 0.7 mm, vibration of 1000 to 10000 Hz was applied, and sprayed into cold air. Rumen-passed vitamin D against coagulation 3 , the particle size distribution was measured based on the particle size measurement method (sieving method) of the Japanese Pharmacopoeia. The vibration is set as a sine wave with a p-p value of 5 mm.

[0074] In the above, the vibration granulation device 100 used in this embodiment is as figure 1 shown. like figure 1 As shown, the vibration granulation apparatus 100 used in t...

Embodiment 1-2

[0081] Example 1-2: Analysis of the structure of the obtained particles

[0082] According to the sieving method of the Japanese Pharmacopoeia, particles having a particle diameter of 1000 μm to 1519 μm were obtained from the obtained particles, and analyzed in more detail. In this example, especially the distribution of pore size was analyzed.

[0083] The pore size was measured by mercury intrusion porosimetry using a mercury porosimeter. The measurement was performed using Auto Pore III (manufactured by Micrometrics). The particles having a particle size of 1000 μm to 1519 μm obtained above were degassed, mercury was injected into the particles, and the relationship between the amount of mercury infiltrated into the particles and the pressure applied at that time was investigated. The pore size was calculated using the Washburn equation,

[0084] D=-4γCOSθ / P

[0085] {where, D is the pore diameter, γ is the surface tension of mercury (ie 480 dynes / cm), and θ is the cont...

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Abstract

To provide: a low-production-cost production method for a rumen-bypassing agent that simultaneously protects an active ingredient from elimination and decomposition in a first stomach and improves release behavior in a target organ; and granules obtained by means of the production method. The present invention provides a method for producing a rumen-bypassing preparation, the method involving, forexample, application of vibration to a die head that has at least one spraying port that contains a molten material that combines a coating agent for the rumen-bypassing preparation and a nutrient that causes bypassing of the rumen, or application of vibration to the molten material, so as to cause the molten material to be sprayed from the spraying port.

Description

technical field [0001] The present invention relates to a method for producing a rumen-passing preparation that is low in production cost and capable of simultaneously avoiding the release and decomposition of active ingredients in the rumen, and increasing the release behavior in the target organ, and the rumen-passing preparation obtained thereby . Background technique [0002] In order to avoid the release and decomposition of active ingredients such as nutrients in the rumen in ruminants, thereby improving the absorption of active ingredients by ruminants, rumen-passed preparations have been developed, and commercialized rumen-passed preparations already exist. As the shape of the rumen-passing preparation, there are granules and dosage forms having a pellet-like shape. However, in the case of expanded dosage forms such as pellets, it is easy to avoid the release and decomposition of the active ingredient in the rumen, but there are problems such as disintegration in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/10A23K20/142A23K20/174A23K40/30
CPCA23K20/174A23K20/142A23K50/10A23K40/35A23K20/158A23K40/10A23V2002/00A23V2200/22A23V2250/06A23V2250/194A23V2250/70A23V2250/7106A23V2250/063A23V2250/0632A23V2250/704
Inventor 奥谷飞土佐野宪幸吉川文明浪花英树
Owner 生物科学株式会社