Real-time high-resolution spatio-temporal distribution imaging method and system for focused ultrasonic cavitation

Abstract

The invention provides a real-time high-resolution spatio-temporal distribution imaging method and system for focused ultrasonic cavitation. A cavitation acoustic scattering signal is filtered to obtain a steady state and an inertial cavitation signal; an existing passive acoustic imaging algorithm is modified based on a high-resolution coherence coefficient to obtain a high-resolution steady state and an inertial cavitation image; the cavitation image is screened, the additional cavitation energy is removed, the steady state and an inertial cavitation feature image are obtained through the principal component analysis, and on the basis, the spatio-temporal distribution of the steady state and the inertial cavitation is obtained. The method can solve the problems that active ultrasound imaging can only obtain cavitation microbubble distribution and cannot obtain the spatio-temporal distribution of a cavitation activity, and passive acoustic imaging is poor in resolution and lacks effective cavitation spatio-temporal distribution calculation methods, provide an effective means for cavitation transient physics process researches and focused ultrasound therapy evaluation, and lay thefoundation for the clinical application of ultrasound-guided and monitored focused ultrasound therapy systems.

Description

technical field [0001] The invention belongs to the field of ultrasonic cavitation physics and application and ultrasonic imaging technology, and specifically relates to a real-time high-resolution time-space distribution imaging method and system of focused ultrasonic cavitation. Background technique [0002] Cavitation refers to a series of dynamic processes in which cavitation nuclei in liquids oscillate, grow, shrink, and collapse under the action of external physical fields (such as ultrasonic fields, laser fields, etc.). , in vitro lithotripsy, drug release, hemostasis, thrombolysis and tumor thermal ablation and other fields are used. According to the different dynamic behaviors of bubbles, cavitation can be divided into two types: steady-state cavitation and inertial cavitation. Steady-state cavitation mainly refers to the nonlinear vibration behavior of microbubbles under the action of low sound pressure, while inertial Melting mainly refers to the instantaneous ru...

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Problems solved by technology

However, the existing passive acoustic imaging algorithms based on time-exposure acoustics have extremely poor spatial resolution performance due to factors such as microbubble interactions, array transducer defects, limited array aperture and bandwidth; at the same time, there is also a lack of effective The calculation method of the temporal and spatial distribution of cavitation activity cannot meet the clinical needs of a real-time monitoring system for focused ultrasound therapy

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