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Radix lithospermi extract as well as preparation method and application thereof

A technology of comfrey extract and herbal medicinal materials, which is applied in the direction of pharmaceutical formulations, plant raw materials, cosmetic preparations, etc., can solve problems such as potential safety hazards, and achieve the effects of less damage, avoiding residues, and protecting color

Active Publication Date: 2019-03-08
广州市络捷生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention provides a comfrey extract and its preparation method and application, which solves the problem that the existing comfrey extract mostly uses organic solvents for extraction and purification and is mostly used for medicine, so that the comfrey extract remains Organic solvents, there are certain safety hazards

Method used

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  • Radix lithospermi extract as well as preparation method and application thereof
  • Radix lithospermi extract as well as preparation method and application thereof
  • Radix lithospermi extract as well as preparation method and application thereof

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preparation example Construction

[0039] The invention provides a preparation method of comfrey extract, comprising the following steps:

[0040] Step 1: Pulverizing the comfrey medicinal material to obtain comfrey medicinal material powder;

[0041] Step 2: Carrying out micro-fluidic extraction of comfrey powder to obtain comfrey extract;

[0042] The solvent of the micro-jet extraction is cosmetic base oil and / or edible oil, both of which are non-organic solvents, so the obtained comfrey extract has no organic solvent residue and is safe and reliable.

[0043] Further, the mass ratio of the solvent to the comfrey medicinal material is 2-30:1, more preferably 2-20:1, even more preferably 2-10:1.

[0044] Further, the cosmetic base oil is selected from white mineral oil, squalane or ethylhexyl palmitate, more preferably ethylhexyl palmitate.

[0045] Further, the edible oil is selected from olive oil, corn oil, soybean oil or sunflower oil, more preferably corn oil.

[0046] Further, the temperature of the ...

Embodiment 1

[0101] Grind 10kg of comfrey medicinal material, add 50kg of ethylhexyl palmitate to it, stir evenly, place in a micro-fluidic extractor for extraction at a refrigerant temperature of 15°C and a feed rate of 20L / min to obtain the extracted liquid. The extract was subjected to solid-liquid separation through a centrifuge at a rotational speed of 8000 rpm, the separated liquid was collected, and the separated liquid was separated and purified by a ceramic membrane with a pore size of 500 nm, and the filtrate was collected to obtain the oil-soluble comfrey extract.

Embodiment 2

[0103] Grind 20kg of comfrey medicinal material, add 60kg of ethylhexyl palmitate to it, stir evenly, place in a microfluidic extractor, and extract under the conditions of refrigerant temperature 20°C and feed rate 20L / min, to obtain extract. The extract was subjected to solid-liquid separation through a centrifuge at a rotational speed of 8000 rpm, the separated liquid was collected, and the separated liquid was separated and purified by a ceramic membrane with a pore size of 500 nm, and the filtrate was collected to obtain the oil-soluble comfrey extract.

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Abstract

The invention relates to the technical field of plant extraction and in particular relates to radix lithospermi extract as well as a preparation method and application thereof. The preparation methodof the radix lithospermi extract, disclosed by the invention, comprises the following steps of step 1, crushing a radix lithospermi medicinal material to obtain radix lithospermi medicinal material powder; step 2: carrying out micro-jet extraction on the radix lithospermi medicinal material powder to obtain radix lithospermi extract, wherein a solvent in the micro-jet extraction is matrix oil forcosmetics and / or edible oil. In the preparation method, a non-organic solvent matrix oil for the cosmetics and / or the edible oil are / is used, so that residues of an organic solvent in the radix lithospermi extract are avoided and the utilization safety of the radix lithospermi extract is ensured. Furthermore, the radix lithospermi extract prepared by the preparation method is oil-soluble radix lithospermi extract; the preparation method has the advantages that the extraction rate of p-hydroxylnaphthoquinone total pigments is high, the damage to effective components of radix lithospermi is lessand the effect of the radix lithospermi is easy to express sufficiently; meanwhile, the original color and luster of the radix lithospermi are also protected.

Description

technical field [0001] The invention relates to the technical field of plant extraction, in particular to a comfrey extract and its preparation method and application. Background technique [0002] Comfrey is the dried root of Arnebia euchroma (Royle) Johnst. Nature and flavor are sweet, salty, cold, heart-guiding, liver meridian. In traditional Chinese medicine, it is mostly used for blood heat and poison, purple and black spots, impervious measles, sores, eczema, water and fire burns, clearing heat and cooling blood, promoting blood circulation and detoxification, and clearing rashes. Anti-freckle effect. The main effective substances in comfrey are shikoninone compounds, mainly including shikonin, acetylshikonin, β-dimethylacrylshikonin, isovalerylshikonin, isobutyrylshikonin, etc. [0003] Current studies have shown that shikonin has a good antibacterial effect on Gram-positive bacteria, such as Staphylococcus aureus, Enterococcus faecium and Bacillus. In addition, sh...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K36/30A61Q19/00A61Q17/00A61P31/04
CPCA61P31/04A61Q17/005A61Q19/00A61K8/9789A61K36/30
Inventor 彭颖华黄裕
Owner 广州市络捷生物科技有限公司
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