Application of Xinmaian medicine to promotion of hair growth

A technology for hair growth and use, applied in the directions of medical preparations containing active ingredients, plant raw materials, active ingredients of hydroxyl compounds, etc., can solve problems such as Xinmai'an that has not been reported, achieve low treatment efficiency, promote hair growth, The effect of resolving side effects

Active Publication Date: 2019-03-12
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The application of Xinmaian in promoting hair growth has not been reported so far

Method used

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  • Application of Xinmaian medicine to promotion of hair growth
  • Application of Xinmaian medicine to promotion of hair growth
  • Application of Xinmaian medicine to promotion of hair growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Isolation and cultivation of mouse vibrissae follicles

[0023] Xinmaian traditional Chinese medicine composition promotes hair shaft extension

[0024] The Xinmaian traditional Chinese medicine composition, the ginseng extract group and the hair growth agent disclosed in CN 101249140A were respectively made into 10 mg / ml stock solutions and stored at -20°C for later use. With reference to the method of Philpott (Philpott MP, Green MR, Kealey T.Human hairgrowth in vitro.Cell Sci, 1990,97(1):471-476.), the configuration of Williams E serum-free medium was carried out, that is, in Williams E medium Add L-glutamine 2mmol / L, HEPES 2mmol / L, hydrocortisone 10μg / L, bovine insulin 10mg / L, transferrin 10mg / L, sodium selenite 10mg / L, penicillin and streptomycin 100U / L. After 6-week-old mice were sacrificed, their vibrissae hair follicles were collected, separated under a stereoscope, and intact hair follicles were selected for organ culture. 40 hair follicles were se...

Embodiment 2

[0027] Example 2: Effect of Xinmaian Chinese Medicine Composition on DPCs Activity

[0028] DPCs (hair papilla cells) were carried out according to the method described by Williams et al. isolation and cultivation. Briefly, the microdissection of the dermal papilla was performed under a 40X magnification stereoscope, and the divided dermal papilla was transferred to a 35-mm Petri dish with a 30G needle, and the capsule around the dermal papilla was scratched with the needle tip. Broken, put 5 in each dish, add 2ml DMEM+20%FBS, and change the medium every 3 days after the DPCs migrate out. After fusion, the cells were digested with 0.25% trypsin and passaged at 1:3. The subcultured DPCs were cultured in DMEM+10%FBS, and P4DPCs were selected for subsequent experiments. Before inoculating the 96-well plate, the cell concentration of P4DPCs was adjusted to 2.5×104 / ml, 200ul DMEM medium per well, and the experiment was divided into 3 groups, with 6 replicate wells in each group....

Embodiment 3

[0031] Example 3: Effect of Xinmaian Chinese Medicine Composition on Back Hair Growth of C57BL / 6 Mice

[0032] According to Müller- etc. (Müller- S, Handjiski B, Eichmüller S, et al. A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol. 2001.117 (3): 3-15) on the back of 36 C57BL / 6 mice The hair was depilated, and the depilated mice were randomly divided into 3 groups. After 24 hours of hair removal, Xinmaian traditional Chinese medicine composition, ginseng extract and no blank control were administered intragastrically, twice a day, for 10 consecutive days, and the changes in the back skin and coat of the mice were observed. After 10 days of drug withdrawal, 5 hair shafts were randomly pulled out from the back skin of each mouse to measure their length, and the back skin was stained with HE to observe the growth of hair follicles in each group.

[0033] On the 5th day of depilation, it can be obse...

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Abstract

The invention discloses novel application of a Xinmaian medicine. The Xinmaian medicine is used for promoting hair growth. Application to preparation of a medicament for preventing or treating alopecia is safe and efficient and solves problems of potential side effects and low treatment efficiency of existing alopecia treatment medicaments minoxidil and finasteride.

Description

Technical field: [0001] The invention relates to the application of Xinmai'an in promoting hair growth. Background technique: [0002] Hair, as an appendage of the skin, has a cosmetic effect. Alopecia is the phenomenon of hair falling out. The hair that falls out normally is the hair in the catagen and telogen phase. Since the hair entering the catagen and the newly entering the growth phase are constantly in a dynamic balance, it can maintain a normal amount of hair. Pathological alopecia refers to the abnormal or excessive loss of hair. There are many reasons, including hormonal alopecia, neurogenic alopecia, endocrine alopecia, nutritional alopecia, physical alopecia, chemical alopecia, infectious alopecia, symptomatic alopecia, congenital alopecia, etc. Hair loss, seasonal hair loss, etc. [0003] Although hair loss does not affect physical health, it can bring serious mental stress to the person suffering from hair loss. [0004] At present, the drugs for the treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P17/14A61K31/045
CPCA61K36/8968A61P17/14A61K31/045A61K36/258A61K36/481A61K36/537A61K36/65A61K36/71A61K2300/00
Inventor 孙亚彬李楚源李淑如
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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