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Drug for preventing and treating cerebral apoplexy and preparation method of drug

A stroke and drug technology, applied in the field of medicine, can solve problems that have not been seen yet

Inactive Publication Date: 2019-03-15
佳木斯大学附属第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It has been reported that osmanthus phenylethanol glycoside has pharmacological effects such as anti-inflammation, anti-cancer, whitening and lightening, but there is no report on the application of osmanthus phenylethanol glycoside to cardiovascular and cerebrovascular diseases, especially the prevention and treatment of stroke

Method used

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  • Drug for preventing and treating cerebral apoplexy and preparation method of drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: A kind of capsule for prevention and treatment of cerebral apoplexy

[0029] 14 parts of osmanthus phenylethanol glycosides, 50 parts of microcrystalline cellulose, 8 parts of starch slurry, 5 parts of sodium carboxymethyl starch, appropriate amount of magnesium stearate, prepared according to the following method:

[0030] (1) Raw material preparation: take each raw material according to the formula quantity, pulverize osmanthus phenylethanol glycosides through a 60-mesh sieve, and set aside;

[0031] (2) Preparation: mix phenylethanol glycosides with osmanthus fragrans, microcrystalline cellulose, starch slurry, and sodium carboxymethyl starch evenly, then wet granulate, pass through a 12-mesh sieve for granulation, add magnesium stearate, mix evenly, and fill in gelatin capsules Shell, promptly obtains the capsule of the present invention for preventing and treating cerebral apoplexy.

Embodiment 2

[0032] Embodiment 2: A kind of buccal tablet for preventing and treating stroke

[0033] 16 parts of osmanthus phenylethanol glycosides, 8 parts of troxerutin, 20 parts of microcrystalline cellulose, 30 parts of mannitol, 20 parts of sorbitol, 10 parts of powdered sugar, 10 parts of maltodextrin, 5 parts of sodium carboxymethyl starch part, 2 parts of menthol, an appropriate amount of magnesium stearate, prepared according to the following method:

[0034] (1) Prepare raw materials: take each raw material according to the formula quantity, pulverize osmanthus phenylethanol glycoside and troxerutin respectively through a 40-mesh sieve, and mix to obtain a mixed powder for subsequent use;

[0035] (2) Preparation: wet granulation after mixing the mixed powder obtained in step (1) with microcrystalline cellulose, mannitol, sorbitol, powdered sugar, maltodextrin, sodium carboxymethyl starch and menthol, and Sieve through a 12-mesh sieve, add magnesium stearate, mix evenly, and th...

Embodiment 3

[0036] Embodiment 3: a kind of sublingual tablet for preventing and treating stroke

[0037] 14 parts of osmanthus phenylethanol glycosides, 6 parts of troxerutin, 50 parts of mannitol, 40 parts of sorbitol, 10 parts of powdered sugar, 10 parts of maltodextrin, 15 parts of sodium carboxymethyl starch, 2 parts of menthol, An appropriate amount of magnesium stearate is prepared according to the following method:

[0038] (1) Prepare raw materials: take each raw material according to the formula quantity, pulverize osmanthus phenylethanol glycoside and troxerutin respectively through a 40-mesh sieve, and mix to obtain a mixed powder for subsequent use;

[0039] (2) Preparation: mix the mixed powder obtained in step (1) with mannitol, sorbitol, powdered sugar, maltodextrin, sodium carboxymethyl starch and menthol, then wet granulate, pass through a 12-mesh sieve for granulation , add magnesium stearate, mix evenly and then press into tablets to obtain the sublingual tablet for pr...

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Abstract

The invention relates to a drug for preventing and treating cerebral apoplexy and a preparation method of the drug. The drug for preventing and treating cerebral apoplexy contains osmanthus phenylethanoid glycosides and a pharmaceutically acceptable carrier. The pharmacological study indicates that osmanthus phenylethanoid glycosides have anticoagulant and oxidative stress resistant effects, neurological function damage of cerebral arterial thrombosis can be effectively prevented and treated, and the drug can be applied to prevention and treatment of cerebral apoplexy, especially cerebral arterial thrombosis. When osmanthus phenylethanoid glycosides are combined with other active ingredients such as rutin, troxerutin, heparin and bilobalide, especially troxerutin, the treatment effect is better.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to a medicine for preventing and treating stroke and a preparation method thereof. Background technique [0002] According to epidemiological research, there are more than 300 million patients with cardiovascular and cerebrovascular diseases in my country. Cardiovascular and cerebrovascular diseases have become the diseases that cause the most deaths among residents in our country, and they are still increasing year by year. They have become a major public health problem in our country. question. [0003] Stroke, also known as "stroke" and "cerebrovascular accident", is a general term for a class of diseases whose main symptoms are cerebral ischemia and hemorrhagic injury. It is mainly divided into hemorrhagic stroke and ischemic stroke. Ischemic stroke accounts for about 80% of strokes. There are various pathogenic factors leading to stroke, including high blood pressure, athe...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K45/06A61P9/10A61P7/02
CPCA61K31/7048A61K45/06A61P7/02A61P9/10A61K2300/00
Inventor 杨慧李洪滨张世华
Owner 佳木斯大学附属第一医院
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