Medicinal composition for improving sensitivity of anti-tumour medicament and application thereof in preparation of anti-tumour medicament

Abstract

The invention discloses a medicinal composition for improving the sensitivity of an anti-tumour medicament and the application thereof in preparation of the anti-tumour medicament. The composition comprises effective dose of sulfasalazine and nano-zinc oxide and a pharmaceutically acceptable carrier, and can be used for preparing a tumour medicament sensitizer. The combined use of the sulfasalazine and the nano-zinc oxide can achieve a synergistic effect and improve the tumour cancer cell killing effect of a traditional chemotherapy medicament, a molecular targeted medicament and immunotherapymedicaments. According to the medicinal composition for improving the sensitivity of the anti-tumour medicament and the application thereof in the preparation of the anti-tumour medicament, the sulfasalazine and the nano-zinc oxide are combined for use for the first time; the sensitivity of the anti-tumour medicament is improved by the synergistic effect of the sulfasalazine and the nano-zinc oxide; moreover, the composition is safe and non-toxic to normal cells, provides a new strategy for the treatment of a clinical tumour patient, and has a good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically refers to a pharmaceutical composition for improving the sensitivity of antitumor drugs and its application in preparing antitumor drugs. Background technique [0002] Cancer is a major public health problem that needs to be solved urgently in China and all regions of the world. On average, millions of people are diagnosed with cancer every year, including more than 200 types of cancer. At present, cancer is the cause of death one of the major diseases. However, due to the poor selectivity of anti-cancer drugs, single-drug therapy has the disadvantages of large toxic side effects or poor therapeutic effect. Therefore, researching a new generation of low-toxicity and high-efficiency drugs has become an urgent task for the treatment of malignant tumors. [0003] Paclitaxel is a natural secondary metabolite isolated and purified from the bark of the gymnosperm plant Taxus chinensis. It has ...

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Problems solved by technology

[0009] At present, there is no report on whether the combination of sulfasalazine and nano-zinc oxide can synergistically improve the cytotoxic effect of antineoplastic drugs on tumor cells

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