Medicinal composition for improving sensitivity of anti-tumour medicament and application thereof in preparation of anti-tumour medicament

A technology of anti-tumor drugs and compositions, applied in the field of medicine, to achieve a good effect of reversing drug resistance, solving drug resistance, and inhibiting expression

Inactive Publication Date: 2019-03-15
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is no report on whether the combination of sulfasalazine and nano-zin

Method used

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  • Medicinal composition for improving sensitivity of anti-tumour medicament and application thereof in preparation of anti-tumour medicament
  • Medicinal composition for improving sensitivity of anti-tumour medicament and application thereof in preparation of anti-tumour medicament
  • Medicinal composition for improving sensitivity of anti-tumour medicament and application thereof in preparation of anti-tumour medicament

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] Experimental example 1 The composition of the present invention and its monomeric compounds reverse the drug resistance of human breast cancer cells to the chemical drug paclitaxel in vitro

[0025] 1.1 Test drugs

[0026] Test Drug 1: Sulfasalazine

[0027] Test drug 2: nano zinc oxide

[0028] Test drug 3: Sulfasalazine and nano-zinc oxide composition (1:0.1)

[0029] Test drug 4: Sulfasalazine and nano-zinc oxide composition (1:0.5)

[0030] Test drug 5: sulfasalazine and nano-zinc oxide composition (1:2)

[0031] Test drug 6: Sulfasalazine and nano-zinc oxide composition (1:4)

[0032] Test drug 7: Sulfasalazine and nano-zinc oxide composition (1:50)

[0033] Test drug 8: Composition of sulfapyridine and nano-zinc oxide (1:4)

[0034] Test drug 9: 5-aminosalicylic acid and nano-zinc oxide composition (1:4)

[0035] Antineoplastic Drugs: Paclitaxel

[0036] 1.2 Experimental scheme and results

[0037] Take paclitaxel-resistant human breast cancer cell line M...

experiment example 2

[0040] Experimental example 2 The composition of the present invention and its monomeric compound reverse the drug resistance of human lung cancer tumor cells to gefitinib in vitro

[0041] 2.1 Test drugs

[0042] Test Drug 1: Sulfasalazine

[0043] Test drug 2: nano zinc oxide

[0044] Test drug 3: Sulfasalazine and nano-zinc oxide composition (1:0.1)

[0045] Test drug 4: Sulfasalazine and nano-zinc oxide composition (1:0.5)

[0046] Test drug 5: sulfasalazine and nano-zinc oxide composition (1:2)

[0047] Test drug 6: Sulfasalazine and nano-zinc oxide composition (1:4)

[0048] Test drug 7: Sulfasalazine and nano-zinc oxide composition (1:50)

[0049] Test drug 8: Composition of sulfapyridine and nano-zinc oxide (1:4)

[0050] Test drug 9: 5-aminosalicylic acid and nano-zinc oxide composition (1:4)

[0051] Antineoplastic Drugs: Gefitinib

[0052] 2.2 Experimental scheme and results

[0053] Take the gefitinib-resistant human lung cancer drug-resistant tumor cell A...

Embodiment 3

[0057] Embodiment 3 composition and its monomer compound treatment of drug resistance animal test one (chemotherapy drug paclitaxel)

[0058] 3.1 Test drugs

[0059] Test Drug 1: Sulfasalazine

[0060] Test drug 2: nano zinc oxide

[0061] Test drug 3: Sulfasalazine and nano-zinc oxide composition (1:0.1)

[0062] Test drug 4: Sulfasalazine and nano-zinc oxide composition (1:0.5)

[0063] Test drug 5: sulfasalazine and nano-zinc oxide composition (1:2)

[0064] Test drug 6: Sulfasalazine and nano-zinc oxide composition (1:4)

[0065] Test drug 7: Sulfasalazine and nano-zinc oxide composition (1:50)

[0066] Test drug 8: Composition of sulfapyridine and nano-zinc oxide (1:4)

[0067] Test drug 9: 5-aminosalicylic acid and nano-zinc oxide composition (1:4)

[0068] Antineoplastic Drugs: Paclitaxel

[0069] 3.2 Experimental scheme and results

[0070] Press 2×10 6 For each cell, logarithmic drug-resistant cells (MCF-7 / PTX) were inoculated in the armpit of female BABL / c ...

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Abstract

The invention discloses a medicinal composition for improving the sensitivity of an anti-tumour medicament and the application thereof in preparation of the anti-tumour medicament. The composition comprises effective dose of sulfasalazine and nano-zinc oxide and a pharmaceutically acceptable carrier, and can be used for preparing a tumour medicament sensitizer. The combined use of the sulfasalazine and the nano-zinc oxide can achieve a synergistic effect and improve the tumour cancer cell killing effect of a traditional chemotherapy medicament, a molecular targeted medicament and immunotherapymedicaments. According to the medicinal composition for improving the sensitivity of the anti-tumour medicament and the application thereof in the preparation of the anti-tumour medicament, the sulfasalazine and the nano-zinc oxide are combined for use for the first time; the sensitivity of the anti-tumour medicament is improved by the synergistic effect of the sulfasalazine and the nano-zinc oxide; moreover, the composition is safe and non-toxic to normal cells, provides a new strategy for the treatment of a clinical tumour patient, and has a good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically refers to a pharmaceutical composition for improving the sensitivity of antitumor drugs and its application in preparing antitumor drugs. Background technique [0002] Cancer is a major public health problem that needs to be solved urgently in China and all regions of the world. On average, millions of people are diagnosed with cancer every year, including more than 200 types of cancer. At present, cancer is the cause of death one of the major diseases. However, due to the poor selectivity of anti-cancer drugs, single-drug therapy has the disadvantages of large toxic side effects or poor therapeutic effect. Therefore, researching a new generation of low-toxicity and high-efficiency drugs has become an urgent task for the treatment of malignant tumors. [0003] Paclitaxel is a natural secondary metabolite isolated and purified from the bark of the gymnosperm plant Taxus chinensis. It has ...

Claims

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Application Information

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IPC IPC(8): A61K33/30A61K31/655A61K45/06A61K31/337A61K31/5377A61P35/00
CPCA61K31/337A61K31/5377A61K31/655A61K33/30A61K45/06A61P35/00A61K2300/00
Inventor 寇龙发陈瑞杰姚情孙锐陈志伟郑海伦蔡爱敏
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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