Near-infrared laser confocal biochip scanner

A laser confocal and biochip technology, applied in the field of biomedicine, can solve the problems of complex optical path structure, high cost, poor detection accuracy and sensitivity, etc., and achieve the effect of improving scanning range, low manufacturing cost and good consistency

Pending Publication Date: 2019-03-15
上海萨迦生物科技有限公司
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  • Abstract
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  • Application Information

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Problems solved by technology

This technology adopts a mechanically driven scanning motion platform structure. Although it solves the problem of scanning range, the detectio...

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  • Near-infrared laser confocal biochip scanner
  • Near-infrared laser confocal biochip scanner
  • Near-infrared laser confocal biochip scanner

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Embodiment Construction

[0032] The embodiment of the present invention discloses a near-infrared laser confocal biochip scanner, which includes an optical module for exciting biochip fluorescence, a mechanical motion scanning platform module for installing biochips, an electrical control module and installing each module as An integrated installation housing assembly, the optical module includes a near-infrared laser and a laser confocal detection system; among them, the laser confocal detection system includes a collimator lens, a laser filter, a dichroic mirror, an objective lens, a fluorescence filter, a converging Lens, pinhole diaphragm and photodetector; the laser emitted by the near-infrared laser passes through the collimating lens to form parallel light, and the parallel light passes through the laser filter and then reflected by the dichroic mirror, and then can be focused on the biochip through the objective lens On the surface, the fluorescence emitted by the biochip after being excited be...

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Abstract

The invention discloses a near-infrared laser confocal biochip scanner. The near-infrared laser confocal biochip scanner comprises an optical module, wherein the optical module comprises a near-infrared laser and a laser cofocal detection system; the laser cofocal detection system comprises a collimator lens, a laser filter, a dichroscope, an objective lens, a fluorescence filter, a convergent lens, a pinhole diaphragm and a photoelectric detector; laser emitted by the near-infrared laser passes through the collimator lens to form parallel light; the parallel light passes through the laser filter, is reflected by the dichroscope and then can be focused on the surface of a biochip through the objective lens; fluorescent light emitted by exciting the biochip becomes the parallel light through the objective lens; the parallel light sequentially passes through the dichroscope and the convergent lens and is focused on the pinhole diaphragm; and the photoelectric detector is placed adjacentto a pinhole and can input a signal into an electrical control module. According to the near-infrared laser confocal biochip scanner disclosed by the invention, the scanning range of a to-be-detectedand scanned biological sample can be effectively improved; meanwhile, detection precision and sensitivity are ensured; in addition, the near-infrared laser confocal biochip scanner is simple in structure, easy to operate and low in manufacturing cost.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a near-infrared laser confocal scanner. Background technique [0002] As stated in the background technology of the invention patent authorized by CN102706846B, bioluminescent imaging technology has been widely used as an indispensable technical means in the field of biomedicine, and it is a powerful tool for observing cell morphology, structure and life phenomena. At present, the widely used biological fluorescence imaging technology is the laser scanning confocal microscope developed in the 1980s. It is characterized by the use of pinhole technology to eliminate the interference of light signals outside the focus on the image, thereby greatly improving the clarity and clarity of the image. Detail resolution with high axial contrast. Since the laser range used by the laser scanning confocal microscope is between 488nm and 647nm, it belongs to the category of visible light, and biolog...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6402
Inventor 许颖原张旭王志慧
Owner 上海萨迦生物科技有限公司
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