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Easily soluble compound sulfachloropyridazine sodium powder

A technology for sulfachlordazine sodium and chlordazine sodium powder is applied in the field of biopharmaceuticals and can solve the problems of poor water solubility of compound sulfachlordazine sodium powder and the like

Pending Publication Date: 2019-03-22
YICHANG SANXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is exactly to provide a kind of method for the preparation of easily soluble compound sulfachlorperazine sodium powder, solve the problem of poor water solubility of the compound sulfachlorperazine sodium powder produced by the company

Method used

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  • Easily soluble compound sulfachloropyridazine sodium powder
  • Easily soluble compound sulfachloropyridazine sodium powder
  • Easily soluble compound sulfachloropyridazine sodium powder

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Test raw materials:

[0016] Sulfachloropyridazine sodium powder, trimethoprim, trimethoprim lactate, sucrose powder, compound sulfachlorpyridazine sodium powder preparation test method:

[0017] (1), raw material micronization:

[0018] 1. 1 kg of trimethoprim is pulverized to 0.01-0.05 μm by jet mill, ready for use.

[0019] 2. 0.5kg of trimethoprim + 1kg of sucrose powder is pulverized to 0.01-0.05μm by jet mill, ready for use.

[0020] 3. Take 1g trimethoprim + 2g powdered sugar, 1g trimethoprim (micronized to 0.01-0.05μm) + 2g powdered sugar, 3g (trimethoprim + sucrose) micronized to 0.01-0.05μm, 1g lactic acid Add trimethoprim + 2g sucrose, respectively add 100ml distilled water to dissolve, stir and let stand to observe the dissolution effect.

[0021] Dissolution and dispersibility comparison (3g→100ml):

[0022]

[0023] (2), mixed preparation:

[0024] Formula: Sulfachlordazine Sodium: 62.5%, Trimethoprim 12.5%, Sucrose: 25.0%

[0025] 1. Sample 1: 62...

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Abstract

The invention relates to easily soluble compound sulfachloropyridazine sodium powder. A formula comprises a mixture of sulfachloropyridazine sodium, trimethoprim and saccharose in the mass ratio of (60 to 65):(10 to 15):(20 to 30). According to a mixing method, after the trimethoprim and saccharose are mixed, the mixture is smashed until the particle size is smaller than 1 micron by a jet mill, and then the mixture is mixed with the sulfachloropyridazine sodium to prepare the product. By adopting the technical scheme, the problems that the product is low in water solubility and a part of powder floats on water and is unlikely to disperse in water are solved; the requirement of the market is solved, and the product with high quality is provided.

Description

technical field [0001] The invention provides an easily soluble compound sulfachlorperazine sodium powder, which belongs to the technical field of biopharmaceuticals. Background technique [0002] Compound sulfachloropyridazine sodium powder is a veterinary drug preparation variety recorded in the Chinese Pharmacopoeia. It is prepared from three raw materials and auxiliary materials: sulfachloropyridazine sodium, trimethoprim and sucrose. It is mainly used for Escherichia coli and Pasteurella in livestock and poultry. Infect. Some products have been trial-produced before, and the water solubility of the products is extremely poor. Some of the powders float on the water surface and are not easy to disperse in the water. The analysis and understanding of the water solubility of the raw and auxiliary materials of sodium powder is due to the insoluble nature of trimethoprim which causes the problem of poor water solubility of the product. Through the test, a method is provided ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/505A61K31/635A61P31/04
CPCA61K9/145A61K31/505A61K31/635A61P31/04A61K2300/00
Inventor 沈联兵陈永强周宜平张安莲
Owner YICHANG SANXIA PHARMA
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