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Bone repairing scaffold capable of simultaneously releasing zinc ions and strontium ions and preparation method of bone repairing scaffold

A technology of strontium ions and zinc ions is applied in the field of bone repair scaffolds that release zinc ions and strontium ions at the same time and the field of preparation thereof, which can solve the problems such as the gap in the comprehensive performance of materials, and achieve the improvement of degradation performance, promotion of osteogenesis, and high mechanical properties. the effect of strength

Active Publication Date: 2019-03-22
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, research has been devoted to the development and preparation of collagen-based or biomaterials that use it as an additive phase for bone tissue repair, but the comprehensive performance and bionic degree of the obtained materials are still far from the application requirements.

Method used

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  • Bone repairing scaffold capable of simultaneously releasing zinc ions and strontium ions and preparation method of bone repairing scaffold
  • Bone repairing scaffold capable of simultaneously releasing zinc ions and strontium ions and preparation method of bone repairing scaffold
  • Bone repairing scaffold capable of simultaneously releasing zinc ions and strontium ions and preparation method of bone repairing scaffold

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preparation example Construction

[0037] The preparation method of strontium-doped octacalcium phosphate of the present invention is:

[0038] (1) prepare the mixed solution containing calcium nitrate and strontium acetate;

[0039] (2) prepare ammonium dihydrogen phosphate and urea solution;

[0040] (3) adding the mixed solution in step (1) dropwise to the ammonium dihydrogen phosphate and urea solution in step (2), stirring at 70-90° C. for 2-4 hours, washing and drying to obtain the Described strontium-doped octacalcium phosphate.

[0041] The preparation method of zinc-doped hydroxyapatite of the present invention is:

[0042] (a) zinc nitrate and calcium nitrate are dissolved in water to obtain calcium zinc solution;

[0043] (b) dissolving diammonium hydrogen phosphate in water, and adjusting the pH value to be 10 to 12 to obtain a diammonium hydrogen phosphate solution;

[0044] (c) Add the diammonium hydrogen phosphate solution dropwise to the calcium and zinc solution, react at 70~90℃ for 3~4h, k...

Embodiment 1

[0046] As an embodiment of the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions according to the present invention, the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions according to the present embodiment includes the following steps:

[0047](1) Mix and grind zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate in a mass ratio of 80:5:15 to obtain a solid phase powder, wherein the degree of substitution of strontium doped with strontium-doped octacalcium phosphate is 10 mol%, the substitution degree of zinc of zinc-doped hydroxyapatite is 5 mol%, and the particle size of the zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate is 50-200 μm;

[0048] (2) Dissolving carboxymethyl chitosan and collagen in citric acid solution, stirring evenly, to obtain a mixed solution, wherein the mass fraction of carbo...

Embodiment 2

[0054] As an embodiment of the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions according to the present invention, the preparation method of the bone repair scaffold that simultaneously releases zinc ions and strontium ions according to the present embodiment includes the following steps:

[0055] (1) Mix and grind zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate in a mass ratio of 82:8:10 to obtain a solid phase powder, wherein the degree of substitution of strontium doped with strontium-doped octacalcium phosphate is 10 mol%, the substitution degree of zinc of zinc-doped hydroxyapatite is 5 mol%, and the particle size of the zinc-doped hydroxyapatite, strontium-doped octacalcium phosphate and calcium silicate is 50-200 μm;

[0056] (2) Dissolving carboxymethyl chitosan and collagen in citric acid solution, stirring evenly, to obtain a mixed solution, wherein the mass fraction of carb...

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Abstract

The invention discloses a bone repairing scaffold capable of simultaneously releasing zinc ions and strontium ions and a preparation method of the bone repairing scaffold. According to the bone repairing scaffold, solid-phase powder is mixed with a solution containing carboxymethyl chitosan and collagen; a mixture is frozen to form an oriented ice crystal; finally, the ice crystal is sublimated under the action of freeze drying; after the ice crystal is sublimated, an oriented lamellar macropore is formed in a material in situ and the connectivity of a porous structure is relatively high. Thescaffold disclosed by the invention takes zinc-doped hydroxyapatite as a zinc source, strontium-doped octacalcium phosphate as a strontium source and calcium silicate as a silicon source; the three materials have different degradation speeds, so that the releasing speeds of the zinc ions, the strontium ions and silicon ions are different; the content of the zinc-doped hydroxyapatite, the strontium-doped octacalcium phosphate and the calcium silicate is adjusted so that the degradation performance of the scaffold can be further improved and bone formation is promoted. The scaffold disclosed bythe invention is used as a biomedical material and has a good application prospect when being applied to the field including bone tissue repairing and the like.

Description

technical field [0001] The invention relates to the technical field of bone repairing materials, in particular to a bone repairing scaffold that simultaneously releases zinc ions and strontium ions and a preparation method thereof. Background technique [0002] As an important tissue in the human body, although bone has the ability of bone regeneration and self-repair, for bone defects caused by tumors, trauma, and abnormal bone growth, in the case that the self-healing of bone alone cannot be healed, it is necessary to use implant materials to assist the damage. Tissue repair and healing. From the perspective of bone tissue self-healing, an ideal bone repair scaffold needs to have good biocompatibility, biodegradability, a three-dimensional porous structure and a complex shape that matches the defect site. [0003] Porous bone repair scaffolds have a high specific surface area and space, which is conducive to the loading of active factors, cell adhesion growth, extracellul...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/56A61L27/54A61L27/50A61L27/20A61L27/24A61L27/12A61L27/02
CPCA61L27/025A61L27/12A61L27/20A61L27/24A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/412A61L2300/45A61L2300/604A61L2430/02C08L5/08
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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