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Triple markers for diagnosing colorectal cancer and application thereof

A triple marker, colorectal cancer technology, applied in the field of triple markers for diagnosing colorectal cancer, can solve problems such as low efficiency, low specificity, and immaturity, and achieves improved sensitivity, improved detection rate, The effect of improving the survival rate

Inactive Publication Date: 2019-03-22
武雪亮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] (1) There are few types of markers for the diagnosis of colorectal cancer, the specificity is not high, the efficiency is low, and they are not yet mature;

Method used

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  • Triple markers for diagnosing colorectal cancer and application thereof
  • Triple markers for diagnosing colorectal cancer and application thereof

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Embodiment Construction

[0024] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0025] The triple markers for the diagnosis of colorectal cancer provided by the embodiment of the present invention include: miR-106a, CA242, and CYFRA-21.

[0026] Below in conjunction with accompanying drawing, the application principle of the present invention is described in detail;

[0027] Such as figure 1 As shown, the triple marker application method provided by the embodiment of the present invention includes:

[0028] S101: Collect 6ml of venous blood from the patient before colon cancer surgery and 7 days after surgery, and record the patient's name and collection time;

[0029] S102: Let the collected venous...

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Abstract

The invention belongs to the technical field of biomedicine and discloses triple markers for diagnosing colorectal cancer and application thereof. The triple markers for diagnosing the colorectal cancer comprise miR-106a, CA242 and CYFRA-21. Serum is obtained through venous blood centrifugation to detect the level of the CA242 and the CYFRA-21; and mi-RNA is extracted by utilizing the serum, cDNAis synthesized through reverse transcription to detect the level of the CYFRA-21. By adopting the miR-106a, CA242 and CYFRA-21 triple markers for detection, the diagnosis sensitivity, specificity andaccuracy degree of the colorectal cancer are improved, the detection rate of early colorectal cancer is increased, a colorectal cancer operation can be conducted in advance and the survival rate of patients is greatly increased. The selected miR-106a is combined with a target m RNA specific site, the regulation and control effect after transcription is achieved and the generation of protein is directly influenced; and furthermore, multiple mi-RNA is related to generation, development and transfer of tumors.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a triple marker for diagnosing colorectal cancer and its application Background technique [0002] At present, the existing technology commonly used in the industry is as follows: among the existing tumor markers of colorectal cancer, the effect of thymidylate synthase on the prognosis is being evaluated, and it may be applied to determine the prognosis. In addition, it can also predict the disease Late response to chemotherapy drug 5-FU; microsatellite instability, u PA / PAI-1, Ras, p53 can all be used to judge the prognosis, but some are still in the research and observation stage, the effect is not very satisfactory, and There are few types, low specificity, low efficiency, and are not yet very mature. [0003] In summary, the problems in the prior art are: [0004] (1) There are few types of markers for the diagnosis of colorectal cancer, the specificity is not high, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158C12Q2600/166C12Q2600/178
Inventor 武雪亮屈明杨东东
Owner 武雪亮