Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A vaccine transdermal delivery device based on acoustically induced microwell array

A technology of microwell array and delivery device, which is applied in the direction of microneedle, drug device, hypodermic injection device, etc., which can solve the problems of high cost, complicated process, and inability to deliver macromolecular vaccine antigens

Active Publication Date: 2020-10-02
SHENZHEN UNIV
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention provides a vaccine transdermal delivery device based on an acoustically induced micropore array to solve the problems of inability to deliver macromolecular vaccine antigens, painful delivery process, complicated process and high cost in the existing technology of percutaneous administration for immunization. Problems such as poor delivery area accuracy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A vaccine transdermal delivery device based on acoustically induced microwell array
  • A vaccine transdermal delivery device based on acoustically induced microwell array
  • A vaccine transdermal delivery device based on acoustically induced microwell array

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: please refer to Figure 1-3 , this embodiment discloses a vaccine transdermal delivery device 1 based on an acoustically induced microwell array, which includes: a main control system 11 connected to the main control system 11 The high-frequency intense focused ultrasound excitation component 12, and the sound-permeable immune patch 13 for applying to the skin for drug administration; the high-frequency strong focused ultrasound excitation component 12 includes a high-frequency ultrasonic signal generation system 121, and the high-frequency The first ultrasonic transducer 122 connected to the high-frequency ultrasonic signal generation system 121, the conical coupling catheter 123 connected with the first ultrasonic transducer 122; the conical coupling catheter 123 is placed in the acoustic On the permeable immune patch 13, it is used to conduct the acoustic energy of the first ultrasonic transducer 122 to the immune patch; the high-frequency ultrasonic signa...

Embodiment 2

[0052] Example 2: Reference Figure 4-5 , based on the above-mentioned embodiment, this embodiment provides a vaccine transdermal delivery device 1 based on an acoustically induced microwell array, wherein,

[0053] The first ultrasonic transducer 122 is an annular hollow first ultrasonic transducer 122; the annular hollow area is provided with an accommodating cavity 122a.

[0054] Further, the vaccine transdermal delivery device 1 based on the sound-induced microwell array also includes an ultrasonic echo signal monitoring system 14 connected to the main control system 11;

[0055] The ultrasonic echo signal monitoring system 14 includes a second ultrasonic transducer 141 and a signal monitoring component 142 electrically connected to each other; the outer diameter of the second ultrasonic transducer 141 is not larger than the accommodating cavity 122a The inner diameter of is used to be placed in the accommodating cavity 122a during monitoring;

[0056] The echo signal mo...

Embodiment 3

[0068] Example 3: Reference Figure 6-7 , based on the above-mentioned embodiment 2, this embodiment provides a vaccine transdermal delivery device 1 based on an acoustically induced microwell array, and the vaccine transdermal delivery device 1 based on an acoustically induced microwell array also includes the main control system 11 connected optical imaging monitoring system 15;

[0069] The optical imaging monitoring system includes an imaging probe 151, and an imaging processing unit 152 connected to the imaging probe 151;

[0070] The outer diameter of the imaging probe 151 is not greater than the inner diameter of the accommodating cavity 122a, and is used to be placed in the accommodating cavity 122a during monitoring;

[0071] The main control system 11 is also used to control the imaging probe 151 to collect images of the sound-permeable immune patch and / or skin, perform real-time or timing imaging, and process the imaging data through the imaging processing unit 152...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A percutaneous vaccine delivery device (1) employing an acoustically induced micropore array. The device (1) comprises a main control system (11), a high-frequency intense-focused ultrasonic excitation assembly (12), and an acoustically permeable immunization patch (13). The high-frequency intense-focused ultrasonic excitation assembly (12) comprises a high-frequency ultrasonic signal generation system (121), a first ultrasonic transducer (122) connected to the high-frequency ultrasonic signal generation system (121), and a conical coupling duct (123) connected to the first ultrasonic transducer (122). The conical coupling duct (123) is placed on the acoustically permeable immunization patch (13) during vaccine administration, such that high-frequency intense-focused ultrasonic energy is output from a front end of the duct to induce formation of micropores and micropore arrays on the skin.

Description

technical field [0001] The invention belongs to the technical field of transdermal administration of immunization, in particular to a vaccine transdermal delivery device based on an acoustically induced micropore array. Background technique [0002] As the importance of the skin in the immune protection of the human body is gradually revealed, the concept of "skin immunity" has been established. The skin is the first line of defense for the human body against harmful substances in the external environment. There are many immune cells in the superficial skin including the epidermis and dermis, such as dendritic Langerhans cells and dermal dendritic cells. On the one hand, Langerhans cells control the formation of keratin, and on the other hand, they participate in the skin immune response. They are the main antigen-presenting cells in the skin epidermis. Usually the epidermis of the skin is about 100 microns thick. If the antigen can reach the epidermis, it can activate the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0061A61M2205/058
Inventor 胡亚欣杨梅陈昕
Owner SHENZHEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com