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Composition of cisplatin and sodium hyaluronate

A technology of sodium hyaluronate and composition, which is applied in the direction of drug combinations, medical preparations containing active ingredients, inorganic active ingredients, etc., can solve the problems of large toxic and side effects of platinum compounds, and achieve good anti-tumor effect and safety Good results

Inactive Publication Date: 2019-03-29
JIANGSU TARGET BIOMEDICINE RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problem of large toxic and side effects of existing anti-tumor drug platinum compounds, the object of the present invention is to provide a composition of cisplatin and sodium hyaluronate, and apply it to the preparation of anti-tumor drugs

Method used

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  • Composition of cisplatin and sodium hyaluronate
  • Composition of cisplatin and sodium hyaluronate
  • Composition of cisplatin and sodium hyaluronate

Examples

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Embodiment 1

[0019] Cell line and culture: 2 liver cancer cell lines (BEL-7402, Hep-G2), 5 pancreatic cancer cell lines (BxPC-3, Capan-1, Colo357, Miapaca-2, Panc-1), 6 lung cancer cell lines (A427 , A549, NCI-H1299, NCI-H2170, NCI-H358, NCI-H460), 3 colorectal cancer cell lines (Colo205, Lovo, RKO), 6 breast cancer cell lines (HCC-1806, MCF-7, MDA- MB-231, MDA-MB-361, MDA-MB-436, TD-47), cervical cancer cell line 1 (Hela), these cells were donated by Nanjing University, with DMEM / RPMI1640 / McCoy containing 10% fetal bovine serum '5a medium at 37°C, 5% CO 2 The cells were cultured in an incubator, and the medium was changed every 2 to 3 days, and cells in the logarithmic growth phase were taken for the experiments.

[0020] Cell proliferation assay (MTT method): Take cancer cells in logarithmic growth phase and make 2×10 4 Cells / mL suspension, 100 μL per well was added to a 96-well culture plate. A reagent control group, a tumor cell control group and an experimental group with different...

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PUM

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Abstract

The invention relates to the fields of organic synthesis and pharmaceutical chemistry, in particular to a composition of cisplatin and sodium hyaluronate. The cisplatin and sodium hyaluronate disclosed by the invention are combined for drug administration, and can be applied to the preparation of anti-tumor medicaments. Pharmacological experiments show that the composition has obvious tumor-inhibiting effect on different cancer cells. Specifically, the composition of the cisplatin and the sodium hyaluronate has obvious anti-tumor effect, and the combination of the two compounds has a dosage range; the combined composition can effectively relieve the toxic and side effects brought by the independent administration of platinum drugs; and the combined composition has potential development value for novel anti-tumor medicaments with high efficiency, low toxic and side effects and anti-drug resistance.

Description

technical field [0001] The present invention relates to the field of organic synthesis and medicinal chemistry, in particular to compositions, preparation methods and applications thereof. Background technique [0002] Cancer is a common and frequently-occurring disease that seriously endangers human health. Overcoming cancer cells has always been a hot research topic at home and abroad. Chemotherapy is one of the main anti-malignant methods used in systemic therapy, but it also damages other cells while fighting tumor cells. Therefore, it is urgent to seek a low-toxicity and high-efficiency anti-tumor drug for anti-tumor therapy. [0003] Platinum-based antitumor compounds have become indispensable and most widely used drugs in cancer chemotherapy. Since cisplatin, as the first-generation antitumor drug, was first approved by the U.S. Food and Drug Administration (FDA) in 1978, platinum antitumor drugs began to enter people's field of vision and were rapidly used in the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/243A61P35/00A61K31/728
CPCA61K31/728A61K33/24A61P35/00A61K2300/00
Inventor 华子春穆飞飞
Owner JIANGSU TARGET BIOMEDICINE RES INST
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