Application of MT-2A gene SNP locus in detecting susceptibility to heavy-metal poisoning

A MT-2A, heavy metal technology, applied in the field of biomedical molecular detection, can solve problems such as less research, achieve the effects of reducing manual operations, controlling detection costs, and saving time

Active Publication Date: 2019-03-29
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are few studies on the relationship between MT-2A gene polymorphism and susceptibility to heavy metal (such as cadmium) poisoning

Method used

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  • Application of MT-2A gene SNP locus in detecting susceptibility to heavy-metal poisoning
  • Application of MT-2A gene SNP locus in detecting susceptibility to heavy-metal poisoning
  • Application of MT-2A gene SNP locus in detecting susceptibility to heavy-metal poisoning

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Embodiment 1

[0054] Embodiment 1. The newly discovered SNP site on the MT-2A gene is related to the susceptibility to heavy metal (cadmium) poisoning (case-control analysis)

[0055] 1. Taking the Chinese Han workers who were exposed to cadmium-polluted working environment for more than one year as the research object, according to the national occupational chronic cadmium poisoning diagnostic standard GBZ3-2006, the people who were diagnosed with chronic cadmium poisoning with mild or above as the case group (i.e. cadmium poisoning susceptibility group), and the people without any symptoms of cadmium poisoning were used as the control group. After statistical analysis, there was no significant difference in age, gender, and working years between the two groups (P>0.05).

[0056] 2. Detect the genotypes of the SNP site g.178 (G>A) of the above-mentioned case group (i.e. the cadmium poisoning susceptibility group) and the control group, and use the known SNP site g .47 (A>G) (the 47th posi...

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Abstract

The application discloses application of an MT-2A gene SNP locus in detecting susceptibility to heavy-metal poisoning. The SNP locus is the 178th nucleotide of MT-2A genes, wherein G is greater than A, the sequence of the MT-2A genes is as shown in SEQ ID No.7. G and A of the SNP locus are significantly different between a case group and a control group, G is a susceptible allele or high-risk allele of cadmium poisoning, A is a non-susceptible allele or low-risk allele of the cadmium poisoning, so that the base type of the locus is detected and the genotype of the locus is determined, and thenthe susceptibility to the heavy-metal (such as cadmium) poisoning or risks of the heavy-metal poisoning can be detected, patients with the heavy-metal poisoning can be screened, susceptible genes ofthe heavy-metal poisoning can be identified or assisted, and single nucleotide polymorphism associated with the heavy-metal poisoning or metabolism can be detected. The application and product provided by the invention are of great value in identifying the susceptible population of the heavy-metal poisoning, thereby reasonably preventing the heavy-metal poisoning.

Description

technical field [0001] The invention belongs to the technical field of biomedical molecular detection, and specifically relates to the application of MT-2A gene SNP sites in detecting heavy metal poisoning susceptibility. Background technique [0002] The original meaning of heavy metals refers to metals with a specific gravity greater than 5 (generally speaking, metals with a density greater than 4.5 grams per cubic centimeter), including gold, silver, copper, iron, mercury, lead, cadmium, etc. Heavy metals accumulate in the human body to a certain extent. Can cause chronic poisoning. The heavy metals mentioned in terms of environmental pollution mainly refer to heavy elements with significant biological toxicity such as mercury (mercury), cadmium, lead, chromium, and metalloid arsenic. Heavy metals are very difficult to be biodegraded. On the contrary, they can be enriched by hundreds of times under the biomagnification of the food chain, and finally enter the human body....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 叶秀峰刘文兰徐迹孙波张晓丽唐婕赵卫华
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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