Production mold for micro-fluidic chip and preparation method and application thereof

A microfluidic chip and preparation process technology, applied in laboratory utensils, laboratory containers, chemical instruments and methods, etc., can solve the problems of difficult mold processing, low precision, and rising costs.

Inactive Publication Date: 2019-04-02
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present invention proposes a mold for preparing a microfluidic chip, aiming to solve the problems of difficult processing and low precision of existing molds
[0007] The embodiment of the present invention also provides a preparation process of a microfluidic chip, which aims to solve the problem of the cost increase caused by the failure of the mold caused by the increase in the number of molding times of the mold, and the problem of the decrease in the precision of the microfluidic chip, and can better control the cost

Method used

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  • Production mold for micro-fluidic chip and preparation method and application thereof

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preparation example Construction

[0035] The application of the above-mentioned preparation mold of the microfluidic chip in the preparation of the microfluidic chip.

[0036] A preparation process for a microfluidic chip, comprising the following steps:

[0037] A conformal mold with the same size as the microfluidic channel of the microfluidic chip is prepared;

[0038] Molding the heated and softened intermediate mold preform with the same-shaped mold to prepare the intermediate mold;

[0039] Plating a composite coating on the surface of the intermediate mold to obtain a coated intermediate mold;

[0040] The microfluidic chip is prepared by molding the heated and softened chip preform by using the coating intermediate mold.

[0041] By preparing a conformal mold with the same shape and size as the microfluidic chip, and then preparing an intermediate mold with the conformal mold, and coating the intermediate mold with a composite coating. The microfluidic chip is prepared through the intermediate mold,...

Embodiment 2

[0059] This embodiment provides a preparation process for preparing a microfluidic chip using the preparation mold 100 of the embodiment, including the following steps:

[0060] 1.1 Prepare tungsten carbide as a raw material into a mold 110 of the same shape as the size of the microfluidic chip, especially the microfluidic channel of the microfluidic chip;

[0061] 1.2 Select the intermediate mold raw material to be heated and softened, and after obtaining the softened raw material, use the same-shaped mold 110 to reverse the mold, and prepare the softened raw material into an intermediate mold 120;

[0062] 1.3 Coating an inert metal rhenium coating on the surface of the intermediate mold 120 to obtain a coated intermediate mold 120;

[0063] 1.4 Select glass raw material as the raw material of the microfluidic chip, heat and soften it, and then mold it to obtain the microfluidic chip.

[0064] Wherein, the strain point temperature of the coating intermediate mold 120 is hig...

Embodiment 3

[0066] This embodiment provides a preparation process for preparing a microfluidic chip using the preparation mold 100 of the embodiment, including the following steps:

[0067] 1.1 Using nickel phosphide as a raw material to prepare a conformal mold 110 that is consistent with the size of the microfluidic chip, especially the microfluidic channel of the microfluidic chip;

[0068] 1.2 Select the intermediate mold raw material to be heated and softened, and after obtaining the softened raw material, use the same-shaped mold 110 to reverse the mold, and prepare the softened raw material into an intermediate mold 120;

[0069] 1.3 Coating an inert metal rhenium coating on the surface of the intermediate mold 120 to obtain a coated intermediate mold 120;

[0070] 1.4 Select the resin raw material as the raw material of the microfluidic chip, heat and soften it, and then mold it to obtain the microfluidic chip.

[0071] Wherein, the strain point temperature of the coating interme...

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Abstract

The invention provides a production mold for a micro-fluidic chip and a preparation method and an application thereof and belongs to the technical field of biochemical instrument and equipment production. In embodiments, during the preparation of the micro-fluidic chip, the production mold can greatly prolong the service life of a mold in the same shape, so that production cost of a glass micro-fluidic chip is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of preparation of biochemical instruments and equipment, in particular to a preparation mold for a microfluidic chip and its preparation process and application. Background technique [0002] Microfluidics is the integration of basic operating units such as sample preparation, reaction, separation, detection, cell culture, sorting, and lysis involved in the fields of biology, chemistry, and medical analysis into a chip of several square centimeters. A technical means to automatically complete the whole process of analysis. From a physical structure point of view, a microfluidic chip is a system that manipulates a small volume of fluid to flow in a small channel or component, where the size of the channel and component is between 10 and 1000 μm, and the amount of fluid carried is 10 μm. -9 ~10 -8 L range. The microchannel network and components in the microfluidic chip are the core of the microfluidic chip...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707
Inventor 解加庆牛纪苹张硕高鹏陈军周天丰聂富强
Owner NORTHWEST A & F UNIV
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