Doxycycline temperature-sensitive in situ gel uterus perfusion fluid for sows and preparation method thereof

A body gel uterus and doxycycline technology, which is applied in the field of doxycycline temperature-sensitive in vivo gel uterine perfusion solution and its preparation, can solve the problems of sick sows such as anorexia, reduced drinking water, and complicated etiology. Achieve the effect of strong tissue positioning, low irritation and good biocompatibility

Active Publication Date: 2019-04-05
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, postpartum endometritis in sows is a deep infectious inflammation, and the etiology is more complicated and harmful. The sick sows are anorexic, depressed, and drinking water is reduced. Trouble requires a lot of manpower and material resources, etc.

Method used

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  • Doxycycline temperature-sensitive in situ gel uterus perfusion fluid for sows and preparation method thereof
  • Doxycycline temperature-sensitive in situ gel uterus perfusion fluid for sows and preparation method thereof
  • Doxycycline temperature-sensitive in situ gel uterus perfusion fluid for sows and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1. A doxycycline temperature-sensitive in vivo gel uterine perfusion solution for sows, consisting of the following components by weight percentage: doxycycline raw material 2%; poloxamer 40720%; poloxamer Sham 1885%; Magnesium chloride 4.6%; Sodium bisulfite 0.2%, pH adjuster ethanolamine (adjust pH to 4.0±0.2), balance water.

[0054] 2. The method for preparing the above-mentioned doxycycline thermosensitive in vivo gel uterine perfusion solution comprises the following steps:

[0055] S1. Sprinkle the prescribed amount of temperature-sensitive material and temperature regulator evenly on the water surface, stir evenly, and put it in a refrigerator at 4°C for 24 hours until it is fully swollen to form a clear solution;

[0056] S2. Add the metal complexing agent, antioxidant, and principal agent to the solution in step S1 in sequence, stir thoroughly, and dissolve by ultrasonic;

[0057] S3. Adjust the pH of the solution in step S2 to 4.0±0.2 with a pH regulator, an...

Embodiment 2

[0059] 1. A doxycycline temperature-sensitive in vivo gel uterine perfusion solution, which is composed of the following components in weight percentage: 2% of doxycycline raw material, 20% of poly-N-isopropylacrylamide, polyethylene glycol Alcohol 5%, magnesium oxide 4.6%, sodium thiosulfate 0.2%, pH regulator 10% sodium hydroxide, balance water.

[0060] 2. The method for preparing the above-mentioned doxycycline thermosensitive in vivo gel uterine perfusion solution comprises the following steps:

[0061] S1. Sprinkle the prescribed amount of temperature-sensitive material and temperature regulator evenly on the water surface, stir evenly, and refrigerate at 10°C for 12 hours to fully swell to form a clear solution;

[0062] S2. Add the metal complexing agent, antioxidant, and principal agent to the solution in step S1 in sequence, stir thoroughly, and dissolve by ultrasonic;

[0063] S3. Adjust the pH of the solution in step S2 to 4.0±0.2 with a pH regulator, and then put...

Embodiment 3

[0065] 1. A doxycycline temperature-sensitive in vivo gel uterine perfusion solution, consisting of the following components in weight percentage: 2% doxycycline raw material, 20% chitosan, 5% polyethylene glycol, EDTA -2Na 4.6%, sodium bisulfite 0.2%, pH adjuster 10% sodium hydroxide, the balance water.

[0066] 2. The method for preparing the above-mentioned doxycycline thermosensitive in vivo gel uterine perfusion solution comprises the following steps:

[0067] S1. Sprinkle the prescribed amount of temperature-sensitive material and temperature regulator evenly on the water surface, stir evenly, and wait for 36 hours in the refrigerator at 0°C to fully swell to form a clear solution;

[0068] S2. Add the metal complexing agent, antioxidant, and principal agent to the solution in step S1 in sequence, stir thoroughly, and dissolve by ultrasonic;

[0069] S3. Adjust the pH of the solution in step S2 to 4.0±0.2 with a pH regulator, and then put it in a refrigerator at 0° C. u...

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Abstract

The invention discloses doxycycline temperature-sensitive in situ gel uterus perfusion fluid for sows and a preparation method thereof. The doxycycline temperature-sensitive in situ gel uterus perfusion fluid is prepared from a main drug, a temperature-sensitive material, a temperature regulator, a metal complexing agent, an antioxidant, a pH (Potential of Hydrogen) regulator and ultrapure water.A preparation has a solution-gel transformation property and biological adhesion performance; compared with conventional sow uterus perfusion fluid, the preparation can be rapidly transformed into semi-solid gel from liquid at drug administration parts, the perfusion fluid can reach deeper parts of a uterus and can be tightly adhered to the surface of a uterine mucosa; the preparation can act on the drug administration parts for a long time, sudden release of a medicine is effectively prevented and uterus positioning and slow release effects can be realized; the clinical drug administration effect is improved and the clinical drug administration convenience for diseases is extremely improved. The preparation has the advantages that the preparation technology is simple and a product is stable and clarified, can be stored at room temperature, and has no toxicity, small irritation and good biocompatibility; the preparation has a good popularization and application prospect.

Description

technical field [0001] The invention belongs to the technical field of veterinary preparations. More specifically, it relates to a doxycycline thermosensitive in vivo gel uterine perfusion solution for sows and a preparation method thereof. Background technique [0002] In recent years, with the increasing subsidy policy for breeding sows in my country, the production scale of self-propagation and self-raising of sows has continued to increase, and the number of sows that can reproduce has continued to increase, and postpartum diseases of sows have also become more and more protrude. If the postpartum management of sows is not in place, it is easy to cause postpartum endometritis, mastitis, agalactia syndrome, etc., especially endometritis is more common, which seriously affects the production performance of sows. Sow endometritis is purulent or mucinous inflammation of pig uterine mucosa. It is caused by pathogenic microorganisms such as E. inflammatory process. Generall...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/10A61K47/02A61K31/65A61P31/04A61P15/00
CPCA61K47/02A61K47/10A61P15/00A61P31/04A61K9/0034A61K9/08A61K31/65
Inventor 黄显会华成云刘宇麻雨桥王波王文湘胡大兴
Owner SOUTH CHINA AGRI UNIV
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