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Composition of a platinum compound and chondroitin sulfate and application thereof

A chondroitin sulfate and composition technology, applied in the fields of organic synthesis and medicinal chemistry, can solve problems such as large toxic and side effects, and achieve the effects of good safety and good tumor suppressing effect

Active Publication Date: 2021-10-08
JIANGSU TARGET BIOMEDICINE RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of large toxic and side effects of existing anti-tumor drugs platinum compounds, the object of the present invention is to provide a composition of platinum compounds and chondroitin sulfate, and apply it to the preparation of anti-tumor drugs

Method used

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  • Composition of a platinum compound and chondroitin sulfate and application thereof
  • Composition of a platinum compound and chondroitin sulfate and application thereof
  • Composition of a platinum compound and chondroitin sulfate and application thereof

Examples

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Embodiment 1

[0019] Cell lines and culture: 2 liver cancer cell lines (BEL-7402, Hep-G2), 5 pancreatic cancer cell lines (BxPC-3, Capan-1, Colo357, Miapaca-2, Panc-1), 6 lung cancer cell lines (A427 , A549, NCI-H1299, NCI-H2170, NCI-H358, NCI-H460), 3 colorectal cancer cell lines (Colo205, Lovo, RKO), 6 breast cancer cell lines (HCC-1806, MCF-7, MDA- MB-231, MDA-MB-361, MDA-MB-436, TD-47), a cervical cancer cell line (Hela), these cells were donated by Nanjing University, with DMEM / RPMI1640 / McCoy containing 10% fetal bovine serum '5a medium, at 37°C, 5% CO 2 Cultivate in an incubator, change the medium every 2-3 days, and take the cells in the logarithmic growth phase for the experiment.

[0020] Cell proliferation detection (MTT method): Take cancer cells in the logarithmic growth phase to make 2×10 4 cells / mL suspension, 100 μL per well was added to a 96-well culture plate. A reagent control group, a tumor cell control group and an experimental group of various concentrations of drugs...

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Abstract

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition of a platinum compound and chondroitin sulfate and an application thereof. The combined administration of the platinum compound and chondroitin sulfate disclosed in the present invention can be applied to the preparation of antitumor drugs. Pharmacological experiments show that it has obvious antitumor effects on different cancer cells, specifically including: the present invention The combination of the platinum compound and chondroitin sulfate has obvious anti-tumor effect, and the combined use of the composition can effectively relieve the toxic and side effects caused by the single administration of the platinum-based drug; Anticancer drugs with side effects and resistance to drug resistance have potential development value.

Description

technical field [0001] The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method and an application thereof. Background technique [0002] Cancer is a common and frequently-occurring disease that seriously endangers human health. Overcoming cancer cells has always been a hot topic in research at home and abroad. Chemotherapy is a main anti-cancer method for systemic treatment, but while it fights tumor cells, it also damages other cells. Therefore, it is imminent to seek a low-toxicity and high-efficiency anti-tumor drug for anti-tumor treatment. [0003] Platinum antineoplastic compounds have become an indispensable and most widely used drug in cancer chemotherapy. Since cisplatin, as the first generation of antineoplastic drug, was approved for marketing by the Food and Drug Administration (FDA) of the United States in 1978, platinum antineoplastic drugs began to enter people's field of vision a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61K31/555A61K31/282A61K33/243A61P35/00
CPCA61K31/282A61K31/555A61K31/737A61K33/24A61P35/00A61K2300/00
Inventor 华子春穆飞飞
Owner JIANGSU TARGET BIOMEDICINE RES INST