Method for extracting, separating and purifying lycium barbarum polysaccharide, lycium barbarum glycopeptide and preparation method thereof

A technology of Lycium barbarum polysaccharides and purification methods, which is applied to glycopeptide components, pill delivery, capsule delivery, etc., can solve the problems that the yield of Lycium barbarum products is less than 1%, products with satisfactory efficacy cannot be obtained, and the yield of Lycium barbarum is less than 1%. , to achieve the effect of preventing genetic damage, ensuring efficacy, and enhancing immunity

Pending Publication Date: 2019-04-12
EAST CHINA UNIV OF SCI & TECH
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  • Abstract
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  • Application Information

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Problems solved by technology

Lycium barbarum polysaccharide is a water-soluble polysaccharide, which is the most important active ingredient in wolfberry, with a relative molecular mass of 68-200; Lycium barbarum polysaccharide is one of the main active ingredients in wolfberry, which has the functions of enhancing immunity, anti-aging, enhancing hematopoietic function, To prevent genetic damage and other effects, most of the prior art utilizes the crude product of Lycium barbarum polysaccharide; the purification method of the current existing technology is to use the traditional alcohol precipitation water extraction process, resulting in a yield of less

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  • Method for extracting, separating and purifying lycium barbarum polysaccharide, lycium barbarum glycopeptide and preparation method thereof
  • Method for extracting, separating and purifying lycium barbarum polysaccharide, lycium barbarum glycopeptide and preparation method thereof
  • Method for extracting, separating and purifying lycium barbarum polysaccharide, lycium barbarum glycopeptide and preparation method thereof

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Embodiment 1

[0053] Among all the components of Lycium barbarum fruit, LBP (a polysaccharide) is the most studied because it is believed to be mainly responsible for different biological effects with potential health benefits. Appropriate procedures are designed to obtain high yields of pure LBP extracts, and the actual efficacy of LBP can be chemically characterized and tested through in vitro, in vivo, and clinical studies.

[0054] The detailed process of the present invention is: after harvesting, the wolfberry fruit is stored after being dried, frozen and powdered.

[0055] The time interval between harvest and storage pretreatment has a profound impact on the qualitative and quantitative properties of the final LBP product. In the treatment of this process, freezing can prevent the action of intracellular enzymes, which can change the polysaccharide substrate, so this process is considered to be the most important in all stages before extraction, and it is generally frozen for more t...

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Abstract

The invention belongs to the technical field of extraction, separation and purification; and discloses a method for extracting, separating and purifying lycium barbarum polysaccharide, lycium barbarumglycopeptide and a preparation method thereof. The lycium barbarum polysaccharide has the effects of enhancing immunity, preventing aging, enhancing hematopoiesis, preventing genetic damage and the like; the lycium barbarum polysaccharide (LBP) is a complex polysaccharide composed of acidic heteropolysaccharide and polypeptide or protein, and has glycopeptide structure of Glycano-O-Ser; the anti-tumor effect of the lycium barbarum glycopeptide is finished through extremely complex regulation and control modes: the apoptosis expression of tumor cells is induced; and the immunity of the body totumor cells is enhanced. The lycium barbarum polysaccharide can obviously improve the condition of tumor-bearing mice, prolong the life of the tumor-bearing mice with peritoneal effusion type by 41%-85%, and obviously inhibit the growth of the two types of solid tumors, and the inhibition rate reaches 81.0% and 72.9% respectively.

Description

technical field [0001] The invention belongs to the technical fields of extraction, separation and purification, and in particular relates to a method for extracting, separating and purifying wolfberry polysaccharide, wolfberry glycopeptide and a preparation method. Background technique [0002] At present, the prior art commonly used in the industry is like this: the nature and flavor of wolfberry fruit are sweet and flat; the nature and flavor of wolfberry leaves are bitter and sweet; cool in nature. Functionally, wolfberry can nourish the liver, nourish the kidney and nourish the lungs. Lycium barbarum leaves have the specific effect of tonifying deficiency and benefiting essence, clearing away heat and improving eyesight. Lycium barbarum polysaccharide is a water-soluble polysaccharide, which is the most important active ingredient in wolfberry, with a relative molecular mass of 68-200; Lycium barbarum polysaccharide is one of the main active ingredients in wolfberry, w...

Claims

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Application Information

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IPC IPC(8): C08B37/00C07K1/14A61K9/20A61K9/48A61K38/14A61P35/00
CPCA61K38/14A61P35/00A61K9/20A61K9/48C07K1/145C08B37/0003C08B37/006
Inventor 滕鑫
Owner EAST CHINA UNIV OF SCI & TECH
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