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Blood-lipoid and special protein composite quality control product

A technology for special proteins and quality control products, which is applied in the direction of material inspection products, measuring devices, instruments, etc., can solve the problems of coexistence and reduce interference, and achieve the effect of improving anti-interference performance and stability performance, and improving anti-interference performance and stability performance

Inactive Publication Date: 2019-04-12
BIOBASE BIODUSTRY (SHANDONG) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to prepare a composite quality control product containing 12 indicators, alleviate the current situation that the composite quality control product of domestic in vitro diagnostic reagents is overly dependent on imports, and solve the problem of multiple coexistence and reduce interference in the product

Method used

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  • Blood-lipoid and special protein composite quality control product
  • Blood-lipoid and special protein composite quality control product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The invention prepares an anti-interference and stable composite quality control product containing multiple blood lipids and special proteins. In specific implementation, the serum is calf serum, the control group is serum containing five anti-interference substances, and the conventional group is not Serum containing five anti-interference substances. The contents of the five anti-interference substances are BSA 2.0-10%, polyethylene glycol 5ml / L, PEG20000 1-20g / L, sodium fluoride 2g / L, and ATP 0.5-1.5%. Wait for the 6 selected standard substances to be added in one time and mix them thoroughly, and then use the filter and the dispensing machine to separate the liquid composite composite quality control product. (According to the addition amount of each item, each item is separately lyophilized and tested. The present invention No longer repeat it, just provide test data). The freeze-drying process adopts 1h pre-cooling, 3.5h freeze-drying, and 20h draining. The pres...

Embodiment 2

[0019] The present invention adopts the formula of adding the anti-interference substance in Example 1 for stability test, and the comparison in this example is the first test result. Generally speaking, there are two types of composite quality control products circulating in the market, liquid type and freeze-dried powder type; if the content of the item can be divided into separate quality control products and composite quality control products. The composite quality control product containing multiple items prepared by the present invention is a freeze-dried powder type, and the freeze-dried powder generally has a validity period that exceeds the liquid-type composite quality control product. Therefore, we conduct a stability tracking monitoring of the self-developed composite quality control product containing 12 indicators. Most manufacturers of stability testing use the Arrhenius equation to simulate and speculate, the real-time tracking used in the present invention. In ...

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Abstract

The invention provides a blood-lipoid and special protein composite quality control product. The blood-lipoid and special protein composite quality control product is prepared from twelve components of C3, C4, apolipoprotein A1, apolipoprotein B, high-density lipoprotein, low-density lipoprotein, C-reactive protein, IGA, IGM, IGG, total cholesterol and glycerinum, and addition is carried out according to the order. A used matrix is calf serum, and inductive anti-interference matter is 2.0-10% of BSA, 5ml / L of polyethylene glycol, 1-20g / L of PEG20000, 2g / L of sodium fluoride and 0.5-1.5% of ATP. Composite quality control freeze dried aquatic products are prepared with the help of a freeze-drying technology.

Description

Technical field [0001] The invention belongs to the technical field of in vitro diagnosis, and particularly relates to a composite quality control product of blood lipids and special proteins. Background technique [0002] With the improvement of living standards in China, the medical standards of the Chinese people are gradually improving, but 70% of in vitro diagnostic reagents are mainly imported from Europe and the United States. my country's in vitro diagnostic reagents have made a qualitative leap between 2000 and 2018. Through domestic and foreign exchanges, technology introduction and independent development of in vitro diagnostic reagents, my country's in vitro diagnostic reagent industry has sprung up like bamboo shoots after a rain, and is ready to take off. But we have to face the reality that China still relies on imports in many directions of antibodies and quality control products, and independent development of antibodies and quality control products is imminent. ...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/92
CPCG01N33/6803G01N33/92
Inventor 甘宜梧李建营王美丽
Owner BIOBASE BIODUSTRY (SHANDONG) CO LTD
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