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Method capable of remarkably increasing monoester-type alkaloid of aconite roots

A technology of monoester alkaloids and aconite, which is applied in pharmaceutical formulations, plant raw materials, medical preparations containing active ingredients, etc., can solve the problems of long processing cycle, low content and difficult quality control.

Inactive Publication Date: 2019-04-16
SICHUAN ACAD OF FOOD & FERMENTATION INDS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the content of the active ingredient monoester alkaloid can only be guaranteed to be ≥0.010%, which is still very low
Moreover, the processing technology level is low, the processing cycle is long, and the quality is difficult to control. These are the shortcomings of traditional processed aconite.

Method used

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  • Method capable of remarkably increasing monoester-type alkaloid of aconite roots
  • Method capable of remarkably increasing monoester-type alkaloid of aconite roots
  • Method capable of remarkably increasing monoester-type alkaloid of aconite roots

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A method for significantly improving aconite monoester alkaloids, comprising the following steps:

[0025] 1) Wash the aconite, soak it with gallbladder to obtain gallbladder aconite;

[0026] 2) Slicing the gallbladder aconite obtained in step 1) so that its thickness is about 5 mm, and then boiling the gallbladder aconite slices with boiling water to make it thoroughly boiled;

[0027] 3) Rinse the gallbladder slices processed in step 2) with tap water, and lower the temperature to normal temperature;

[0028] 4) The cooled gallbladder slices are then soaked in water to remove the gallbladder until the tongue is slightly numb in the mouth;

[0029] 5) Cook the soaked gallbladder slices at normal pressure until the oily surface shines, then add microbial suspension to ferment, the amount of microbial suspension is based on submerging the gallbladder slices; the strains are Paecilomyces wantii, purchased from the Culture Collection Center of the Sichuan Provincial Mic...

Embodiment 2

[0032] A method for significantly improving aconite monoester alkaloids, comprising the following steps:

[0033] 1) Wash the aconite, soak it with gallbladder to obtain gallbladder aconite;

[0034] 2) Slicing the gallbladder aconite obtained in step 1) so that its thickness is about 5 mm, and then boiling the gallbladder aconite slices with boiling water to make it thoroughly boiled;

[0035] 3) Rinse the gallbladder slices processed in step 2) with tap water, and lower the temperature to normal temperature;

[0036] 4) Soak the cooled gallbladder slices in water to remove the gallbladder until the tongue is slightly numb in the mouth;

[0037] 5) Cook the soaked gallbladder slices at normal pressure until the oily surface appears glossy, and then add microbial suspension for fermentation; the strain in the microbial suspension is Aspergillus niger, purchased from Sichuan Microbial Resource Platform Culture Collection Center, the preservation number is SICC 3.643. The OD ...

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Abstract

The invention belongs to the technical field of medicine preparing, and particularly relates to a method capable of remarkably increasing monoester-type alkaloid of aconite roots. On the basis of traditional preparation of black prepared aconite roots, sieved pure breed microorganism bacterial suspension after steaming is fermented for 2 days, and strains in the microorganism bacterial suspensionare paecilomyces variotii. By adding the strains, the content of effective component monoester-type alkaloid of unprepared aconite roots can be increased by 11.11%, the aconite roots are prepared intothe black prepared aconite roots or white prepared aconite roots, compared with the content of monoester-type alkaloid in traditional black prepared aconite roots, the effect is best after paecilomyces variotii is added, and the content of monoester-type alkaloid of the aconite roots is increased by 23.18%. The preparation condition with addition of paecilomyces variotii is researched, and when preparing time is 48 h, the initial pH is 8 and temperature is 30 DEG C, the content of monoester-type alkaloid is increased by 47.7% compared with the traditional black prepared aconite roots.

Description

technical field [0001] The invention belongs to the technical field of medicine processing, and specifically relates to a method for significantly increasing aconite monoester-type alkaloids. Background technique [0002] Aconite, also known as aconitum or aconitum, aliases: grass aconitum, salt aconitum, goose flower, iron flower, five poisons. It is not only an authentic Chinese medicinal material produced in Sichuan, but also an important traditional Chinese medicinal material in my country. It has the effect of restoring yang and rescuing the adversity, and is highly valued by traditional Chinese medicine. However, its toxicity is also a clinical concern. [0003] In the "Chinese Pharmacopoeia", the main control indicators are diester alkaloids (neaconitine, hypoaconitine, total amount of aconitine) and monoester alkaloids (benzoyl neoaconitine, benzoyl aconitine, etc.) For the limit inspection of formyl aconitine and benzoyl hypoaconitine), diester-type alkaloids are t...

Claims

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Application Information

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IPC IPC(8): A61K36/714
CPCA61K36/714A61K2236/13A61K2236/15A61K2236/17A61K2236/19
Inventor 李南臻王刚万玉军庹有朋罗丽娟岳晓敏朱志何仲清蔡晓石永胜冯明海黄仲军
Owner SICHUAN ACAD OF FOOD & FERMENTATION INDS
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