Analysis method and device for bone density character heritability

An analysis method, bone density technology, applied in the field of heritability analysis, can solve the problems of wasting manpower and material resources, low accuracy of bone density shape heritability, and a large number of samples

Active Publication Date: 2019-04-16
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology

[0004] In view of this, the purpose of the present invention is to provide a method and device for analyzing the heritability of bone density traits to solve the problem of analyzing the heritability of bone density shape through gene association research methods in the prior art. A lot of manpower and material resources are wasted, and the technical problem of low accuracy in evaluating the heritability of bone density shape

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  • Analysis method and device for bone density character heritability
  • Analysis method and device for bone density character heritability
  • Analysis method and device for bone density character heritability

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[0046] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, not all of them. the embodiment. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0047] According to an embodiment of the present invention, an embodiment of a method for analyzing the heritability of bone density traits is provided. It should be noted that the steps shown in the flow charts of the accompanying drawings can be executed in a computer system such as a set of computer-executable instructions , and, although a logical order is shown in the flowcharts...

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Abstract

The invention provides an analysis method and device for bone density character heritability and relates to the technical field of heritability analysis. According to the method, gene-type data of a to-be-detected object is acquired; according to the gene-type data, a full-transcriptome correlation analysis TWAS obvious gene is determined; the TWAS obvious gene is subjected to hereditary analysisto obtain the bone density character heritability, a full-transcriptome management analysis method TWAS is used for screening the full-genome correlation analysis GWAS obvious gene again, the experiment analysis to the GWAS obvious gene is reduced, the accuracy of the heritability is high, and through risk grading for the heritability, the heredity interpretability is further achieved from the scientific angle.

Description

technical field [0001] The invention relates to the technical field of heritability analysis, in particular to a method and device for analyzing heritability of bone density traits. Background technique [0002] The full name of bone mineral density is bone mineral density, which is an important indicator of bone strength, expressed in grams per cubic centimeter, and is an absolute value. Bone mineral density is an important marker of bone quality, reflecting the degree of osteoporosis, and an important basis for predicting the risk of fracture. Many related studies have shown that bone density has a strong genetic component, and its heritability is about 50%-80%. In the existing methods for analyzing the heritability of bone density traits, it is mainly to compare the DNA sequencing data in large samples through the whole gene association research method to find the single nucleotide polymorphism sites related to bone density, and through these genetic variation sites Ass...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/20G16B40/00
Inventor 朱木春殷鹏艾红胡帆
Owner SHENZHEN INST OF ADVANCED TECH
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