70 results about "Genomewide association" patented technology

The present invention relates to a method for the generation of a facial composite from the genetic profile of a DNA-donor. The method comprises the steps of a) subjecting a biological sample to genotyping thereby generating a profile of genetic markers associated to numerical facial descriptors (NFD) for said sample, b) reverse engineer a NFD from the profile of the associated genetic variants and constructing a facial composite from the reverse engineered numerical facial descriptors (NFDs). The present invention also relates to a method for identifying genetic markers and / or combinations of genetic markers that are predictive of the facial characteristics, (predictive facial markers) of a person, said method comprising the steps of: a) capturing images of a group of individual faces; b) performing image analysis on facial images of said group of individual faces thereby extracting phenotypical descriptors of the faces; c) obtaining data on genetic variation from said group of individual and d) performing a genome-wide association study (GWAS) to identify said predictive facial markers.

The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility to Crohn's disease and / or their response to a particular drug or drugs.

The invention belongs to the technical field of livestock breeding and relates to a method for breeding high-reproductive-performance breeding rabbits based on SNP. The method comprises the following steps that firstly, resource group establishing and character measuring are conducted, wherein 1, resource group establishing is conducted, and 2, character measuring is conducted; secondly, target SNP selecting and whole genome correlation analyzing are conducted, wherein 1, genome SNP finding and whole genome SNP chip customizing are conducted, 2, whole genome correlation analyzing and verifying are conducted, and 3, SNP gathering is conducted; thirdly, a BLUP method is conducted, wherein a marginal effect value is calculated based on the principles of economics, and the animal model BLUP method is used for studying rabbit breeding value comprehensive selecting indexes; fourthly, a new M-BLUP rabbit breeding method is conducted, wherein the genetic effect of significant SNP locuses is estimated, molecule marking and BLUP are combined, and the new M-BLUP rabbit breeding method is established; fifthly, the new M-BLUP rabbit breeding method is used for breeding the high-reproductive-performance rabbits. The SNP assistant selection breeding method is adopted, special strains can be bred, and a high-reproductive-performance meat rabbit matched system can be established.

The invention discloses a colorectal cancer susceptibility diagnostic kit and an application of SNP (single nucleotide polymorphism) in preparation of the diagnostic kit. The SNP sites are rs12522693 and rs17836917. By means of genome-wide association study, the inventors prove remarkable correlation between an allele at the rs12522693 site G and an allele at the rs17836917 site A and colorectal cancer susceptibility through a screening stage, first stage verification and second stage verification. By means of detecting the genotypes of the rs12522693 site and / or the rs17836917 site, the colorectal cancer susceptibility of a testee can be predicted, and thus early prevention and treatment of the disease can be promoted. The colorectal cancer susceptibility diagnostic kit can be used for detecting the genotypes of the rs12522693 site and / or the rs17836917 site by using known technologies in the field so as to judge whether the testee has colorectal cancer susceptibility or not.

The invention relates to the field of biotechnology, and in particular to a method for effectively anchoring a candidate gene region of a quantitative trait. The method is co-localized with a genome-wide association study and a quantitative trait localization method to achieve efficient anchoring of the quantitative trait candidate gene regions. The method achieves effective anchoring of the candidate gene region of the peanut quantitative trait by co-localization with the genome-wide association study and the quantitative trait localization. The method is exemplified by quantitative granule weight, firstly, through a simplified genome sequencing technology, the genome-wide SNP marker development of 165 cultivar peanut core collections in China is carried out; based on a principle of linkage disequilibrium, combined with peanut 100-fruit weight and 100-kernel weight breeding value, the related gene regions related to peanut weight traits are associated; in the previous reports, the QTLmapping results of the grain weight traits are converted to the corresponding genomic physical locations, the co-localization region of the two methods can be obtained, and the method can effectivelyand accurately realize the localization of the genome-wide particle weight-related trait genes.

The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention is useful to define the subset of variations that are most suited as genetic markers to search for correlations with certain phenotypic traits. Additionally, the insights are useful for the development of algorithms and computer programs that convert genotype data into the constituent haplotypes that are laborious and costly to derive in an experimental way. The invention is useful in areas such as (i) genome-wide association studies, (ii) clinical in vitro diagnosis, (iii) plant and animal breeding, (iv) the identification of micro-organisms.

The invention discloses a molecular marker for detecting fusarium head blight (FHB)-resistant QTL Qfhb.hbaas-5AL and a use method. The invention provides an application of a substance for detecting the genotype of an SNP IWB42293 locus of wheat chromosome 5AL in identification or auxiliary identification of resistance of wheat FHB and also provides an application of the substance for detecting thegenotype of the SNP IWB42293 locus of the wheat chromosome 5AL in preparation of a product for identification or auxiliary identification of resistance of the wheat FHB. The anti-FHB locus Qfhb.hbaas-5AL located on a short arm of the wheat 5A chromosome by genome wide association study (GWAS), associated SNP IWB42293 is further converted into common PCR marked M-5AL-Fhb, and the marker can be used for detecting the genotype of the FHB-resistant QTL Qfhb.hbaas-5AL and applied to anti-FHB molecular breeding.

Compositions and methods for the identification of agents useful for the treatment of neurological disorders, including schizophrenia, are provided.

The invention provides a molecular marking method for the major QTL locus qRR5 for the rooting rate in cuttage of catalpa bungei and belongs to the field of molecular genetics. 70 pairs of SSR molecule markers are used for determining gene types of 87 parts of clonal materials of catalpa bungei, and whole genome association linkage analysis is carried out with the combination of the rooting rate in cuttage of catalpa bungei. The major QTL locus qRR5 for the rooting rate in cuttage of catalpa bungei is detected, 13.35% of phenotypic variation is explained, and the SSR molecular marker CB252 is highly remarkably associated with phenotypic variation. The molecular marking method is beneficial to solving the problem of the slow progress of catalpa bungei breeding in China and beneficial to solving the technical problem that the existing breeding technology is high in cost, long in time, poor in stability and the like when applied to increasing the rooting rate in cuttage of catalpa bungei, and breeding of new varieties of catalpa bungei in China and clone forestry development can be accelerated.

The invention relates to a method for screening long oyster broodstock with high glycogen content and related SNP primer pairs. Through the genome-wide association analysis of 486 individuals, 39 SNP signals significantly associated with glycogen located on chromosome 6 of Oyster chinensis were identified. A corresponding detection method was developed for a SNP site at scaffold426_295, 537 bases in this region, and the nucleotide sequence of 500 bp upstream and downstream of the site is shown in SEQ ID No.1. At the same time, compared with CC genotype individuals, the glycogen content of TT genotype individuals at this site was significantly increased by 6.2%. The TT genotype broodstock at this site was screened to guide oyster breeding. The beneficial effect of the invention is that the genotype identification of parent shellfish can be carried out before seed breeding, the TT genotype parent shellfish at this site can be screened, and the glycogen content of progeny can be increased. The results of this study are based on the SNP markers obtained from the genome-wide association analysis of the wild population, and the effect is more stable.

The invention provides a molecular marking method for the major QTL locus qRR5 for the rooting rate in cuttage of catalpa bungei and belongs to the field of molecular genetics. 70 pairs of SSR molecule markers are used for determining gene types of 87 parts of clonal materials of catalpa bungei, and whole genome association linkage analysis is carried out with the combination of the rooting rate in cuttage of catalpa bungei. The major QTL locus qRR5 for the rooting rate in cuttage of catalpa bungei is detected, 13.35% of phenotypic variation is explained, and the SSR molecular marker CB252 is highly remarkably associated with phenotypic variation. The molecular marking method is beneficial to solving the problem of the slow progress of catalpa bungei breeding in China and beneficial to solving the technical problem that the existing breeding technology is high in cost, long in time, poor in stability and the like when applied to increasing the rooting rate in cuttage of catalpa bungei, and breeding of new varieties of catalpa bungei in China and clone forestry development can be accelerated.

The invention provides an analysis method and device for bone density character heritability and relates to the technical field of heritability analysis. According to the method, gene-type data of a to-be-detected object is acquired; according to the gene-type data, a full-transcriptome correlation analysis TWAS obvious gene is determined; the TWAS obvious gene is subjected to hereditary analysisto obtain the bone density character heritability, a full-transcriptome management analysis method TWAS is used for screening the full-genome correlation analysis GWAS obvious gene again, the experiment analysis to the GWAS obvious gene is reduced, the accuracy of the heritability is high, and through risk grading for the heritability, the heredity interpretability is further achieved from the scientific angle.

The invention provides a molecular marking method for the major QTL locus qRR4 for the rooting rate in cuttage of catalpa bungei and belongs to the field of molecular genetics. 70 pairs of SSR molecule markers are used for determining gene types of 87 parts of clonal materials of catalpa bungei, and whole genome association linkage analysis is carried out with the combination of the rooting rate in cuttage of catalpa bungei. The major QTL locus qRR4 for the rooting rate in cuttage of catalpa bungei is detected, 11.43% of phenotypic variation is explained, and the SSR molecular marker CB241 is highly remarkably associated with phenotypic variation. The molecular marking method is beneficial to solving the problem of the slow progress of catalpa bungei breeding in China and beneficial to solving the technical problem that the existing breeding technology is high in cost, long in time, poor in stability and the like when applied to increasing the rooting rate in cuttage of catalpa bungei, and breeding of new varieties of catalpa bungei in China and clone forestry development are greatly accelerated.

The invention provides a molecular marking method for the major gene locus qRN4 for the number of adventitious roots in cuttage of catalpa bungei and belongs to the field of molecular genetics. 70 pairs of SSR molecule markers are used for determining gene types of 87 parts of clonal materials of catalpa bungei, and whole genome association linkage analysis is carried out with the combination of the number of the adventitious roots in cuttage of catalpa bungei. The major gene locus qRN4 for the number of the adventitious roots in cuttage of catalpa bungei is detected, 10.72% of phenotypic variation is explained, and the SSR molecular marker CB250 is highly remarkably associated with phenotypic variation. The molecular marking method is beneficial to solving the problem of the slow progress of catalpa bungei breeding in China and beneficial to solving the technical problem that the existing breeding technology is high in cost, long in time, poor in stability and the like when applied to increasing the number of adventitious roots in cuttage of catalpa bungei, and breeding of new varieties of catalpa bungei in China and clone forestry development can be accelerated.